concept

QUERCETIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about QUERCETIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

373Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	QUERCETIN
Key Genes/Proteins	APP, STING, TNF, VEGF, NRF2
Related Diseases	NEUROINFLAMMATION, STROKE, ALZHEIMER, AUTOPHAGY, SENESCENCE

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    QUERCETIN["QUERCETIN"]
    QUERCETIN -.protects against.-> Diabetic_Nephropathy["Diabetic Nephropathy"]
    QUERCETIN -->|"inhibits"| Renal_Tubular_Epithelial_Cell_["Renal Tubular Epithelial Cell Apoptosis"]
    QUERCETIN -->|"inhibits"| Neuronal_Pyroptosis["Neuronal Pyroptosis"]
    QUERCETIN -->|"inhibits"| PI3K_AKT["PI3K/AKT"]
    QUERCETIN -->|"treats"| Cerebral_Ischemia_Reperfusion_["Cerebral Ischemia/Reperfusion Injury"]
    QUERCETIN -->|"regulates"| PI3K_Akt_NF__B_Signaling_Pathw["PI3K/Akt/NF-kappaB Signaling Pathway"]
    QUERCETIN -.protects against.-> HK_2_Cells["HK-2 Cells"]
    QUERCETIN -->|"modulates"| Microglial_M1_M2_Polarization["Microglial M1/M2 Polarization"]
    MICROGLIA["MICROGLIA"] -->|"inhibits"| QUERCETIN
    ENDOTHELIAL_CELLS["ENDOTHELIAL CELLS"] -->|"target for"| QUERCETIN
    DASATINIB["DASATINIB"] -->|"target for"| QUERCETIN
    CANCER["CANCER"] -->|"regulates"| QUERCETIN
    MACROPHAGES["MACROPHAGES"] -->|"activates"| QUERCETIN
    ISCHEMIA["ISCHEMIA"] -->|"activates"| QUERCETIN

Outgoing (238)

Target	Relation	Type	Str
NEUROINFLAMMATION	activates	phenotype	0.70
HIPPOCAMPUS	activates	brain_region	0.70
STROKE	inhibits	disease	0.70
STING	protects_against	gene	0.65
STING	treats	gene	0.65
TNF	targets	gene	0.65
VEGF	targets	gene	0.65
T CELL	treats	cell_type	0.65
MICROGLIA	treats	cell_type	0.65
ALZHEIMER	targets	disease	0.65
AUTOPHAGY	activates	phenotype	0.65
NRF2	activates	gene	0.65
NRF2	inhibits	gene	0.65
SENESCENCE	treats	phenotype	0.65
SENESCENCE	activates	phenotype	0.65
NEURODEGENERATION	activates	disease	0.65
GLIOSIS	treats	phenotype	0.65
GLIOSIS	inhibits	phenotype	0.65
COGNITIVE DECLINE	treats	phenotype	0.65
COGNITIVE DECLINE	activates	phenotype	0.65
SENESCENCE	inhibits	phenotype	0.65
OXIDATIVE STRESS	activates	phenotype	0.65
TRAUMATIC BRAIN INJURY	causes	disease	0.65
FERROPTOSIS	interacts_with	phenotype	0.65
FERROPTOSIS	treats	phenotype	0.65
STAT3	regulates	gene	0.65
STAT3	inhibits	gene	0.65
AUTOPHAGY	treats	phenotype	0.65
COGNITIVE DECLINE	targets	phenotype	0.65
AGING	activates	phenotype	0.65
TREM2	activates	gene	0.65
COGNITIVE DECLINE	inhibits	phenotype	0.65
FERROPTOSIS	targets	phenotype	0.65
MICROGLIA	depleted_in	cell_type	0.55
PI3K/AKT SIGNALING	activates	concept	0.50
BERBERINE	interacts_with	concept	0.50
MAPK SIGNALING	associated_with	concept	0.50
HK2	associated_with	gene	0.50
ASTROCYTE	associated_with	cell_type	0.50
CORTEX	associated_with	brain_region	0.50
APP	associated_with	gene	0.50
CLU	associated_with	gene	0.50
CR1	associated_with	gene	0.50
TAU	associated_with	protein	0.50
ROS	associated_with	phenotype	0.50
STROKE	associated_with	disease	0.50
AQP4	associated_with	gene	0.50
STING	associated_with	gene	0.50
CGAS	associated_with	gene	0.50
T CELLS	associated_with	cell_type	0.50

Incoming (135)

Source	Relation	Type	Str
APP	activates	gene	0.70
MACROPHAGE	protects_against	cell_type	0.65
MICROGLIA	protects_against	cell_type	0.65
DIABETES	causes	disease	0.65
NEURODEGENERATION	causes	disease	0.65
ALZHEIMER	treats	disease	0.65
ALZHEIMER'S DISEASE	treats	disease	0.65
DIABETES	treats	disease	0.65
MAPK	targets	gene	0.65
MICROGLIA	inhibits	cell_type	0.50
ENDOTHELIAL	associated_with	concept	0.50
ENDOTHELIAL CELLS	associated_with	concept	0.50
FLAVONOIDS	protects_against	concept	0.50
cancer	regulates	disease	0.50
cancer	associated_with	disease	0.50
Pi3K	activates	pathway	0.50
microglia	activates	cell_type	0.50
NF-κB	activates	concept	0.50
Pi3K/Akt	activates	pathway	0.50
microglia	inhibits	cell_type	0.50
Pi3K	inhibits	pathway	0.50
apoptosis	inhibits	process	0.50
Epithelial Cell	inhibits	cell_type	0.50
Pi3K/Akt	inhibits	pathway	0.50
Nephropathy	inhibits	disease	0.50
PI3K/AKT PATHWAY	inhibits	concept	0.50
apoptosis	activates	process	0.50
DIABETES MELLITUS	activates	concept	0.50
Epithelial Cell	activates	cell_type	0.50
Type 2 Diabetes	activates	disease	0.50
apoptosis	protects_against	process	0.50
Epithelial Cell	protects_against	cell_type	0.50
ferroptosis	inhibits	phenotype	0.50
atherosclerosis	inhibits	disease	0.50
Pyroptosis	inhibits	pathway	0.50
Neuroinflammation	associated_with	process	0.50
Neurodegeneration	associated_with	disease	0.50
inflammation	associated_with	pathway	0.50
mTOR	inhibits	entity	0.50
microglia	regulates	cell_type	0.50
ALZHEIMER	regulates	gene	0.50
Alzheimer'S Disease	regulates	disease	0.50
disease	regulates	disease	0.50
ALZHEIMER'S	regulates	concept	0.50
Neuroprotection	interacts_with	process	0.50
ALZHEIMER	associated_with	gene	0.50
DIABETES	associated_with	disease	0.50
DIABETES MELLITUS	associated_with	concept	0.50
Alzheimer Disease	associated_with	disease	0.50
disease	associated_with	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Senescent cell clearance as neurodegeneration therapy

neurodegeneration | 2026-04-04 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

QUERCETIN

Understanding Entity Pages

Wiki Pages (20)

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Progressive Supranuclear Palsy (PSP)

Novel Therapy Index

Device Therapies Comparison for CBS/PSP

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Therapeutics

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

CBS/PSP Treatment Rankings

Mitochondrial Dysfunction in Neurodegeneration

Neuroprotection Strategies in Neurodegeneration

Microglial Senescence Pathway in Neurodegeneration

Peroxisome Pathway in Neurodegeneration

Lipid Peroxidation in Neurodegeneration

Autophagy-Lysosomal Impairment Across Neurodegenerative Diseases

Cellular Senescence in Neurodegeneration

Advanced Glycation End Products in Neurodegeneration

Proteostasis Network Dysfunction Comparison Across Neurodegenerative Diseases

Longevity and Rejuvenation Therapies Landscape

AD Therapeutic Approaches Ranked Scorecard