Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about AQP4 PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
| Gene Symbol | AQP4 |
| Full Name | Aquaporin-4 |
| Protein Family | channel |
| Target Class | Ion Channel |
| Mechanism of Action | Water channel inhibitor or modulator |
| Primary Expression | astrocyte end-feet that surround cerebral blood vessels and in ependymal cells lining the ventricles[@nielsen2003] |
| Druggability | Low (0.35) |
| Clinical Stage | Phase I |
| Molecular Weight | 34 kDa |
| Amino Acids | 323 aa |
| Pathways | Glymphatic Pathway, glymphatic clearance, oxidative stress response, NF-κB Pathway, Complement Cascade |
| GeneCards | AQP4 |
| Human Protein Atlas | AQP4 |
| Associated Diseases | AD, Aging, ALI, alpha-synuclein accumulation, Als |
| Known Drugs/Compounds | Astragaloside IV, dasatinib, MELATONIN, quercetin, riluzole, TGN-020 |
| Interactions | 4R-tau, ABCA1, ALPHA-SYNUCLEIN, ALS, ALZHEIMER, ALZHEIMER'S DISEASE |
| SciDEX Target | View Target Profile (1 clinical trials) |
| SciDEX Hypotheses | SASP-Driven Aquaporin-4 Dysregulation Aquaporin-4 Polarization Rescue CSF/Plasma AQP4 Polarization Index as a Novel Biom (+9 more) |
| KG Connections | 1784 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
graph TD
AQP4["AQP4 PROTEIN"]
BBB["Blood-Brain Barrier"]
Astrocytes["Astrocytes"]
Water_Transport["Water Transport"]
Brain_Edema["Brain Edema"]
ICP["Intracranial Pressure"]
Glymphatic["Glymphatic System"]
Amyloid_Clearance["Amyloid-beta Clearance"]
Neuroinflammation["Neuroinflammation"]
Alzheimers["Alzheimer's Disease"]
Stroke["Ischemic Stroke"]
TBI["Traumatic Brain Injury"]
NMOSD["Neuromyelitis Optica"]
Complement["Complement Activation"]
Cell_Death["Astrocyte Death"]
CNS_Damage["CNS Tissue Damage"]
Astrocytes -->|"expresses"| AQP4
AQP4 -->|"facilitates"| Water_Transport
AQP4 -->|"maintains"| BBB
AQP4 -->|"drives"| Glymphatic
Water_Transport -->|"regulates"| Brain_Edema
Brain_Edema -->|"increases"| ICP
Glymphatic -->|"enhances"| Amyloid_Clearance
Stroke -->|"disrupts"| AQP4
TBI -->|"alters"| AQP4
AQP4 -->|"modulates"| Neuroinflammation
Neuroinflammation -->|"contributes to"| Alzheimers
NMOSD -->|"targets"| AQP4
NMOSD -->|"activates"| Complement
Complement -->|"causes"| Cell_Death
Cell_Death -->|"leads to"| CNS_Damage
classDef central fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px
classDef protective fill:#1a3a2a,stroke:#81c784,stroke-width:2px
classDef pathological fill:#3a1a1a,stroke:#ef5350,stroke-width:2px
classDef disease fill:#3a2a1a,stroke:#ffa726,stroke-width:2px
class AQP4,Water_Transport central
class BBB,Glymphatic,Amyloid_Clearance protective
class Brain_Edema,ICP,Neuroinflammation,Complement,Cell_Death,CNS_Damage pathological
class Alzheimers,Stroke,TBI,NMOSD disease| Target | Relation | Type | Str |
|---|---|---|---|
| AQP4 | references | gene | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| AQP4 | expressed_in | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning AQP4 PROTEIN in their description or question text
No additional research found