concept

ALI

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ALI: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

146Connections

21Hypotheses

30Analyses

0Outgoing

50Incoming

Summary

ALI is a concept in neurodegeneration research. Key relationships include: implicated in, regulates, causes. Associated with SEPSIS. Connected to 146 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	ALI
Key Genes/Proteins	S100A9, CRH, MMP9, MAP1B, MAP2, MAP6
Related Diseases	SEPSIS
Linked Hypotheses	83 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    ALI["ALI"]
    S100A9["S100A9"] -->|"activates"| ALI
    SEPSIS["SEPSIS"] -->|"causes"| ALI
    CRH["CRH"] -->|"regulates"| ALI
    MAP1B["MAP1B"] -->|"implicated in"| ALI
    MAP2["MAP2"] -->|"implicated in"| ALI
    MAP6["MAP6"] -->|"implicated in"| ALI
    LIS1["LIS1"] -->|"implicated in"| ALI
    DCX["DCX"] -->|"implicated in"| ALI
    CD2AP["CD2AP"] -->|"implicated in"| ALI
    HCN1["HCN1"] -->|"implicated in"| ALI

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (146)

Source	Relation	Type	Str
S100A9	activates	protein	0.72
SEPSIS	causes	disease	0.72
CRH	regulates	protein	0.64
MMP9	associated_with	protein	0.60
MAP1B	implicated_in	gene	0.50
MAP2	implicated_in	gene	0.50
MAP6	implicated_in	gene	0.50
LIS1	implicated_in	gene	0.50
DCX	implicated_in	gene	0.50
CD2AP	implicated_in	gene	0.50
HCN1	implicated_in	gene	0.50
SLC16A2	implicated_in	gene	0.50
SLC16A1	implicated_in	gene	0.50
IDH2	implicated_in	gene	0.50
IDH1	implicated_in	gene	0.50
VEGFA	implicated_in	gene	0.50
EEF1A1	implicated_in	gene	0.50
APOB	implicated_in	gene	0.50
MET	implicated_in	gene	0.50
MCL1	implicated_in	gene	0.50
SF3B1	implicated_in	gene	0.50
SMARCA4	implicated_in	gene	0.50
DNA	implicated_in	gene	0.50
LZTR1	implicated_in	gene	0.50
MDM4	implicated_in	gene	0.50
TERT	implicated_in	gene	0.50
NADH	implicated_in	gene	0.50
NAD	implicated_in	gene	0.50
MCU	implicated_in	gene	0.50
LETM1	implicated_in	gene	0.50
REL	implicated_in	gene	0.50
HSPG2	implicated_in	gene	0.50
EFNB1	implicated_in	gene	0.50
TP53	implicated_in	gene	0.50
ERK	implicated_in	gene	0.50
AKT	implicated_in	gene	0.50
SRC	implicated_in	gene	0.50
EPHB4	implicated_in	gene	0.50
RASA1	implicated_in	gene	0.50
CD40	implicated_in	gene	0.50
AQP4	implicated_in	gene	0.50
TCR	implicated_in	gene	0.50
GBM	implicated_in	gene	0.50
C1QA	implicated_in	gene	0.50
C1QC	implicated_in	gene	0.50
C1Q	implicated_in	gene	0.50
SPI1	implicated_in	gene	0.50
LDL	implicated_in	gene	0.50
UNC5B	implicated_in	gene	0.50
NTN1	implicated_in	gene	0.50

Targeting Hypotheses (21)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Beta-Hydroxybutyrate Receptor (HCAR2) Signaling Links Ketone	0.645	neurodegeneration	What are the precise temporal dynamics o
IL-6 Trans-Signaling Blockade at the Oligodendrocyte-Microgl	0.632	neuroinflammation	How do oligodendrocytes initiate neuroin
Direct Toxicity Hypothesis: β-Amyloid Directly Impairs Choli	0.600	-	Do β-amyloid plaques and neurofibrillary
CLU/APOE Duality in Amyloid Clearance Determines Cell-Type-S	0.576	neurodegeneration	What are the cell-type-specific transcri
EPO Set Point Calibration Hypothesis	0.572	endocrinology	Does TRT-induced erythrocytosis actually

TREM2 Signaling Bifurcation with Independent TYROBP-Independ	0.567	neuroinflammation	Why is TYROBP deficiency neuroprotective
Purinergic Signaling Polarization Control	0.554	neurodegeneration	Astrocyte reactivity subtypes in neurode
Microglial-Mediated Tau Clearance Dysfunction via TREM2 Sign	0.533	neuroscience	Circuit-level neural dynamics in neurode
HCN1-Selective Blockade Normalizes Thalamic Rebound Bursting	0.526	synaptic biology	How do P/Q channel deficits paradoxicall
Dissociating SCFA's Dual Signaling Through GPR43/GPR41 Biase	0.525	neurodegeneration	Do SCFAs directly modulate α-synuclein a
Matrix Stiffness Normalization via Targeted Lysyl Oxidase In	0.515	neurodegeneration	Perivascular spaces and glymphatic clear
Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain A	0.512	neurodegeneration	What are the mechanisms by which gut mic
Layer V excitatory neurons show selectively enhanced vulnera	0.510	Alzheimer's disease	SEA-AD Single-Cell Analysis: Cell-Type V
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides	0.509	neurodegeneration	Blood-brain barrier transport mechanisms
TREM2-SYK Signaling Axis Couples OxPC Recognition to Phagocy	0.505	neuroinflammation	What molecular mechanisms enable microgl
C1q Inhibition Prevents Synaptic Mitochondrial Dysfunction v	0.455	neurodegeneration	Why does PRKN-mediated mitophagy, typica
Astrocytic-Mediated Tau Clearance Dysfunction via TREM2 Sign	0.434	neuroscience	Circuit-level neural dynamics in neurode
Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro	0.424	neurodegeneration	What are the mechanisms by which gut mic
Inhibitory Neuron-Selective WNT Signaling Restoration	0.390	neurodegeneration	Which cell types show the most significa
Neuronal Subtype-Specific Alpha-Synuclein Expression Normali	0.382	neurodegeneration	Which cell types show the most significa
Nucleolar Stress Response Normalization	0.378	neurodegeneration	RNA binding protein dysregulation across

Mentioning Analyses (30)

Scientific analyses that reference this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Purinergic signaling elements are correlated with coagulation players in periphe [PMID:35091759]	Schultz IC, Bertoni APS, Wink MR	J Mol Med (Berl)	2022	1
Purinergic Receptors in the Airways: Potential Therapeutic Targets for Asthma? [PMID:35386996]	Thompson RJ, Sayers I, Kuokkanen K, Hall	Front Allergy	2021	1
Variation in glucose homeostasis traits associated with P2RX7 polymorphisms in m [PMID:25719930]	Todd JN, Poon W, Lyssenko V, Groop L, Ni	J Clin Endocrinol Metab	2015	1
Bacteroides coprocola protects dopaminergic neurons in rotenone-induced Parkinso [PMID:41761283]	Liu Z, Nie J, Li Y, Huang M, Chen Z et a	Transl Neurodegener	2026	0
TREM2 deficiency delays postnatal microglial maturation and synaptic pruning, le [PMID:41930604]	Yang HC, Deng YS, Zhang J, Zhang T, Song	J Alzheimers Dis	2026	0
Gut Microbiota-Derived Lipopolysaccharides and Short-Chain Fatty Acids Regulate [PMID:41031863]	Maruyama D, Doan TNM, Tian X, Chaki T, Y	Ann N Y Acad Sci	2025	0
CSF ATP levels correlate with Alzheimer's disease severity and predict progressi [PMID:synthetic_4]	Unknown	JAMA Neurol	2024	0
Astrocyte phenotype switching controlled by purinergic receptor balance regulate [PMID:synthetic_1]	Unknown	Nature Neuroscience	2023	0
P2Y1 agonist enhances astrocyte-mediated neuroprotection via BDNF upregulation [PMID:synthetic_3]	Unknown	Glia	2023	0
Astrocyte phenotype heterogeneity may not fit simple A1/A2 binary classification [PMID:synthetic_8]	Unknown	Cell	2023	0
P2X7 antagonists failed to show efficacy in depression trials despite target eng [PMID:synthetic_6]	Unknown	Mol Psychiatry	2022	0
P2X7 antagonist reduces amyloid pathology and preserves cognition in APP/PS1 mic [PMID:synthetic_2]	Unknown	Neurobiol Dis	2022	0
JNJ-47965567 P2X7 antagonist shows CNS penetration and safety in Phase 2 trial [PMID:synthetic_5]	Unknown	Lancet Psychiatry	2021	0
Lychee (Litchi chinensis Sonn.) Pulp Phenolics Activate the Short-Chain Fatty Ac [PMID:33533603]	Huang G, Wang Z, Wu G, Zhang R, Dong L e	J Agric Food Chem	2021	0
P2Y1 agonists cause platelet activation and thrombotic risk in cardiovascular mo [PMID:synthetic_7]	Unknown	Thromb Haemost	2020	0
Functional coordination and HuR-mediated regulation of mRNA stability during T c [PMID:26490963]	["Blackinton J", "Keene J"]	Nucleic acids research	2016	0
Characterization of a novel function-blocking antibody targeted against the plat [PMID:25593131]	["Karim Z", "Vemana H", "Alshbool F", "L	Arteriosclerosis, thrombosis,	2015	0
Dysregulation of leukocyte gene expression in women with medication-refractory d [PMID:24143878]	Iacob E, Light KC, Tadler SC, Weeks HR,	BMC psychiatry	2013	0
Evidence of HPV subtypes linked with cervical cancer in Nepal. [PMID:28615609]	["Bhusal C", "Manandhar S", "Singh M", "	WHO South-East Asia journal of	2012	0
Purinergic receptors are part of a functional signaling system for proliferation [PMID:12787128]	Greig AV, Linge C, Terenghi G, McGrouthe	The Journal of investigative d	2003	0

ALI

Understanding Entity Pages

Summary

Wiki Pages (20)

Lithium for PSP/CBS — Phase 2 Trial

Histamine

DNA Damage Response in Corticobasal Syndrome

RNASEK — Ribonuclease Kappa

DNA Damage Response in Corticobasal Syndrome

post-covid-neurological-syndrome

epas1-protein

snca-protein

CD2AP Gene — CD2-Associated Protein

MAP6 Gene

SNCA — Alpha-Synuclein

eef1a1

AGER/RAGE Protein

SQSTM1 — Sequestosome 1 (p62)

Cerebral Blood Flow Regulation in Neurodegeneration

DCAF17 Gene - DDB1 and CUL4 Associated Factor 17

C1QA Gene — Complement Component 1q A Chain

TERT Gene

RIPK3 Protein

TARDBP Protein (TDP-43)

Pathway Diagram

Outgoing (0)

Incoming (146)

Targeting Hypotheses (21)

Mentioning Analyses (30)

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

What is the temporal sequence of TREM2 signaling transition from protective to i

Should microtubule-stabilizing drugs be reconsidered as therapeutic targets for

Why does iron chelation therapy worsen outcomes in H63D HFE variant carriers des

What are the specific circulating factors in exercise-conditioned plasma that me

What genetic risk factors predispose individuals to developing CTE following rep

What molecular mechanisms enable microglia to neutralize OxPC-mediated neurodege

Do astrocytes functionally express TRIM46, and can PKCα phosphorylate it to driv

Do β-amyloid plaques and neurofibrillary tangles cause or result from cholinergi

Do SCFAs directly modulate α-synuclein aggregation in vivo at physiologically re

Is HCN1 dysfunction causal or protective in EC layer II neurodegeneration?

Which specific aging-related gene expression changes in mouse brain predict huma

What are the optimal timing windows for TREM2 agonism vs antagonism across disea

What validated biomarkers can determine optimal TFEB activity windows during dis

Which cell-type vulnerability signatures from SEA-AD single-cell data represent

Can pathological vs physiological C1q tagging be distinguished at the molecular

Does SYK activation provide neuroprotection or exacerbate neuroinflammation in e

Do circadian disruptions cause neurodegeneration or result from it?

Does structural 'normalization' of APOE4 domain interactions actually improve am

Do tau-containing vesicles exhibit distinct surface glycosylation patterns compa

What evidence supports Cdk5 activation as THE primary cause of AD versus other e

Mechanistic validation of SEA-AD differential expression hypotheses: Complement

Are autophagy-lysosome defects primary drivers or downstream consequences in spo

How can subcellular compartmentalization defects be measured as biomarkers in li

Can nanobodies achieve selective membrane penetration into tau-containing vesicl

What determines organelle-specific autophagy selectivity in neurodegenerative di

How do protein-protein interactions determine subcellular localization and funct

What determines the spatial organization of autophagy receptors at stress granul

What determines the specificity of calcium-dependent PPP3/calcineurin activation

How do different organelle-specific autophagy pathways coordinate during neurode

Related Papers (20)