Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about arrb1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet. View on Wiki →
| Gene Symbol | ARRB1 |
| Full Name | Arrestin beta 1 |
| Aliases | β-arrestin 1 |
| Chromosome | 11q13.1 |
| Function | ARRB1 recognizes these phosphorylated receptors through multiple phosphate sensors in its N-terminal domain. |
| Molecular Weight | 46 kDa |
| Amino Acids | 418 aa |
| Pathways | MAPK, PI3K |
| UniProt ID | [P49407](https://www.uniprot.org/uniprot/P49407) |
| Ensembl ID | ENSG00000141428 |
| OMIM | 107940 |
| GeneCards | ARRB1 |
| Human Protein Atlas | ARRB1 |
| Associated Diseases | Alzheimer's disease pathogenesis through multiple mechanism |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
ARRB1["ARRB1"]
ARRB1 -->|"inhibits"| autophagy["autophagy"]
ARRB1 -->|"regulates"| MASP1["MASP1"]
ARRB1 -->|"activates"| RAB27A["RAB27A"]
ARRB1 -->|"interacts"| SAMD4["SAMD4"]
ARRB1 -->|"activates"| Carcinoma["Carcinoma"]
ARRB1 -->|"activates"| Hepatitis["Hepatitis"]
ARRB1 -->|"activates"| Autophagy["Autophagy"]
ARRB1 -->|"implicated in"| neurodegeneration["neurodegeneration"]
IL_4["IL-4"] -->|"regulates"| ARRB1
AUTOPHAGY["AUTOPHAGY"] -->|"activates"| ARRB1| Target | Relation | Type | Str |
|---|---|---|---|
| autophagy | inhibits | process | 0.90 |
| MASP1 | regulates | protein | 0.90 |
| Anti-Inflammatory Reactivity | modulates | process | 0.90 |
| RAB27A | activates | protein | 0.85 |
| SAMD4 | regulates | gene | 0.85 |
| SAMD4 | interacts_with | protein | 0.80 |
| Carcinoma | activates | disease | 0.65 |
| Hepatitis | activates | disease | 0.65 |
| Cancer | associated_with | disease | 0.65 |
| FKBP5 | associated_with | gene | 0.60 |
| Autophagy | activates | pathway | 0.60 |
| benchmark_ot_ad_answer_key:ARRB1 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||