Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ASIC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:ASIC | data_in | dataset_row | 0.00 |
| PIEZO | expressed_in | gene | 0.60 |
| TNF | expressed_in | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:ASIC | data_in | dataset_row | 0.00 |
| TNF | downregulates | protein | 0.80 |
| ZO1 | associated_with | gene | 0.35 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Biphasic Ketogenic Intervention Protocol | 0.780 | metabolic-neuroscience | What determines the optimal timing and d |
| Stage-Dependent Biphasic SPP1 Targeting: Early Enhancement F | 0.503 | synaptic-biology | Does SPP1-mediated synaptic engulfment r |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Mobile App-Based Intervention for BPSD in Community-Dwelling Dementia | clinical | dementia with behavioral and p | 0.950 | 0.00 | human patients | proposed | N/A |
| AECII-specific HMGCS2 overexpression in mouse pulmonary fibrosis | validation | idiopathic pulmonary fibrosis | 0.950 | 0.00 | C57BL/6 mice with AECII-specif | proposed | N/A |
| Ketogenic diet fat threshold analysis in wild-type mice | validation | metabolic disease | 0.900 | 0.00 | C57BL/6J wild-type mice | proposed | N/A |
| HMGCS2 gain-of-function in AECII lipid metabolism regulation | exploratory | idiopathic pulmonary fibrosis | 0.900 | 0.00 | human AECIIs | proposed | N/A |
| Ketogenic diet efficacy in diet-induced obese mice | validation | obesity, metabolic disease | 0.900 | 0.00 | C57BL/6J diet-induced obese mi | proposed | N/A |
| Microarray and single-cell RNA analysis of lipid metabolism genes | exploratory | idiopathic pulmonary fibrosis | 0.850 | 0.00 | human patients, mouse models | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Improved tools to study astrocytes. [PMID:32042146] | Unknown | Nat Rev Neurosci | 2020 | 0 |
| Monoaminergic neuropathology in Alzheimer's disease. [PMID:27084356] | Unknown | Prog Neurobiol | 2017 | 0 |
| Algal photoreceptors: in vivo functions and potential applications. [PMID:24081482] | Unknown | Planta | 2014 | 0 |
| Neurobiology of food intake in health and disease. [PMID:24840801] | Morton Gregory J; Meek Thomas H; Schwart | Nature reviews. Neuroscience | 2014 | 0 |
| An in vitro model for neuroscience: differentiation of SH-SY5Y cells into cells [PMID:20413890] | Unknown | J Alzheimers Dis | 2010 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning ASIC in their description or question text
No additional research found