concept

PIEZO

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PIEZO: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

129Connections

1Hypotheses

0Analyses

50Outgoing

46Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	PIEZO
Key Genes/Proteins	TNF-α
Related Diseases	ALS, Inflammation, Hypertension, Aging, Heart Failure
Linked Hypotheses	5 hypotheses

Wiki Pages (11)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    PIEZO["PIEZO"]
    PIEZO -->|"expressed in"| ALS["ALS"]
    PIEZO -->|"expressed in"| Inflammation["Inflammation"]
    PIEZO -->|"activates"| Hypertension["Hypertension"]
    PIEZO -->|"regulates"| Aging["Aging"]
    PIEZO -->|"regulates"| Heart_Failure["Heart Failure"]
    TNF__["TNF-alpha"] -->|"upregulates"| PIEZO
    TNF["TNF"] -->|"upregulates"| PIEZO
    INFLAMMATION["INFLAMMATION"] -->|"expressed in"| PIEZO
    TRPM8["TRPM8"] -->|"expressed in"| PIEZO
    RNA["RNA"] -->|"expressed in"| PIEZO
    TRPA1["TRPA1"] -->|"expressed in"| PIEZO
    AND["AND"] -->|"expressed in"| PIEZO

Outgoing (83)

Target	Relation	Type	Str
uterine contractions	mediates	process	0.90
ALS	expressed_in	disease	0.65
Inflammation	expressed_in	disease	0.65
Hypertension	activates	disease	0.65
Aging	regulates	disease	0.65
ALS	regulates	disease	0.65
ALS	inhibits	disease	0.65
Inflammation	regulates	disease	0.65
Heart Failure	regulates	disease	0.65
Inflammation	associated_with	disease	0.65
Senescence	regulates	disease	0.65
Als	expressed_in	disease	0.65
Als	inhibits	disease	0.65
Fibrosis	activates	disease	0.65
Als	associated_with	disease	0.65
Aging	interacts_with	disease	0.65
Als	regulates	disease	0.65
PIEZO1	expressed_in	gene	0.60
KCNK2	expressed_in	gene	0.60
TNF-Α	expressed_in	gene	0.60
PIEZO1	activates	gene	0.60
KCNK2	activates	gene	0.60
TRPC1	activates	gene	0.60
PIEZO2	activates	gene	0.60
NOTCH	activates	gene	0.60
Angiogenesis	regulates	pathway	0.60
Notch	activates	pathway	0.60
NEURON	activates	gene	0.60
PIEZO1	regulates	gene	0.60
PIEZO2	regulates	gene	0.60
Apoptosis	regulates	pathway	0.60
TRPM8	expressed_in	gene	0.60
RNA	expressed_in	gene	0.60
PKD2	expressed_in	gene	0.60
TRPA1	expressed_in	gene	0.60
FSP1	activates	gene	0.60
TREK-1	activates	gene	0.60
Neuron	therapeutic_target	cell_type	0.60
KLF2	regulates	gene	0.60
UBIQUITIN	regulates	gene	0.60
DTX3L	activates	gene	0.60
NOTCH1	regulates	gene	0.60
DTX1	regulates	gene	0.60
ORAI1	regulates	gene	0.60
Endothelial	regulates	cell_type	0.60
IL-6	activates	gene	0.60
Neuron	activates	cell_type	0.60
T Cell	associated_with	cell_type	0.60
YTHDF1	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60

Incoming (46)

Source	Relation	Type	Str
TNF-α	upregulates	protein	0.85
TNF	upregulates	entity	0.80
INFLAMMATION	expressed_in	gene	0.60
TNF	expressed_in	gene	0.60
TRPM8	expressed_in	gene	0.60
RNA	expressed_in	gene	0.60
TRPA1	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
TRPV4	activates	gene	0.60
FSP1	activates	gene	0.60
GENES	expressed_in	gene	0.60
TREK-1	activates	gene	0.60
GJA1	inhibits	gene	0.60
AND	activates	gene	0.60
AND	associated_with	gene	0.60
GENES	regulates	gene	0.60
DTX3L	activates	gene	0.60
KLF2	regulates	gene	0.60
ORAI1	regulates	gene	0.60
UBIQUITIN	regulates	gene	0.60
NOTCH1	regulates	gene	0.60
AND	inhibits	gene	0.60
DTX1	regulates	gene	0.60
INFLAMMATION	regulates	gene	0.60
IL-6	activates	gene	0.60
INFLAMMATION	associated_with	gene	0.60
GENETIC MUTATIONS	associated_with	gene	0.60
APOPTOSIS	regulates	gene	0.60
AND	regulates	gene	0.60
POSTN	activates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
ANG	activates	gene	0.60
RNA	regulates	gene	0.60
YTHDF1	regulates	gene	0.60
KCNK2	expressed_in	gene	0.60
PIEZO1	expressed_in	gene	0.60
KCNK2	activates	gene	0.60
TRPC1	activates	gene	0.60
PIEZO1	activates	gene	0.60
PIEZO2	activates	gene	0.60
NOTCH	activates	gene	0.60
PIEZO1	regulates	gene	0.60
PIEZO2	regulates	gene	0.60
PKD2	expressed_in	gene	0.60
ASIC	expressed_in	gene	0.60
ZO1	associated_with	gene	0.35

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Piezoelectric Nanochannel BBB Disruption	0.414	neurodegeneration	Blood-brain barrier transport mechanisms

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (16)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Dolutegravir induces endoplasmic reticulum stress at the blood-brain barrier. [PMID:39985305]	Huang C, Qu QR, Hoque MT, Bendayan R	FASEB J	2025	1
Profiling Tight Junction Protein Expression in Brain Vascular Malformations. [PMID:40429705]	Pedrosa L, Mosteiro A, Reyes L, Amaro S,	Int J Mol Sci	2025	1
Autophagy alleviates hypoxia-induced blood-brain barrier injury via regulation o [PMID:33280500]	Yang Z, Lin P, Chen B, Zhang X, Xiao W,	Autophagy	2021	1
ROS-responsive nanogels for brain targeted delivery of icariin in the treatment [PMID:41197818]	["Li X", "Huang J", "Zhou Y", "Chen X",	International journal of pharm	2026	0
Claudins proteins in brain tumors: expression patterns and therapeutic target. [PMID:41399659]	["Romanowicz A", "\u0141ukaszewicz-Zaj\u	Biochemia medica	2026	0
Testicular Gap (CX43) and Tight Junction (OCLN, CLDN3, 5 and 11) Components in t [PMID:41594443]	Goericke-Pesch S, Röhrs L, Wallrabenstei	Animals : an open access journ	2026	0
Stress-induced mitochondrial fragmentation in endothelial cells disrupts blood-r [PMID:40994007]	["Cueva Vargas J", "Belforte N", "Vidal-	Molecular therapy : the journa	2026	0
Bionanoconjugates in Neurodegeneration: Peptide-Nanoparticle Alliances for Next- [PMID:41199078]	["Ranjitha V", "Kumar A", "Kaalappa P"]	Pharmaceutical research	2025	0
Artemether Improves Aβ [PMID:40493345]	["Cai J", "Liu Y", "Gong L", "Deng S", "	Molecular neurobiology	2025	0
Stress-induced mitochondrial fragmentation in endothelial cells disrupts blood-r [PMID:39975311]	["Cueva-Vargas J", "Belforte N", "Vidal-	bioRxiv : the preprint server	2025	0
Mesenchymal Stem Cells Restore Endothelial Integrity and Alleviate Emotional Imp [PMID:40244194]	["Chen A", "Duan Y", "Zhou S", "Du F", "	International journal of molec	2025	0
Claudin-1 impairs blood-brain barrier by downregulating endothelial junctional p [PMID:40018968]	Gowrikumar S, Tarudji A, McDonald BZ, Ba	Tissue barriers	2025	0
Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746]	["Sanadgol N", "Abedi M", "Hashemzaei M"	Journal of nanobiotechnology	2025	0
Antiretroviral drugs efavirenz, dolutegravir and bictegravir dysregulate blood-b [PMID:36969875]	["Huang C", "Hoque T", "Bendayan R"]	Frontiers in pharmacology	2023	0
Increased cerebral expressions of MMPs, CLDN5, OCLN, ZO1 and AQPs are associated [PMID:28490769]	Du Y, Xu JT, Jin HN, Zhao R, Zhao D, Du	Scientific reports	2017	0
Anti-inflammatory activity of Barleria lupulina: Identification of active compou [PMID:27660013]	["Senger D", "Hoang M", "Kim K", "Li C",	Journal of ethnopharmacology	2016	0

PIEZO

Understanding Entity Pages

Wiki Pages (11)

Angelman Syndrome

ginzburg-nerve-endings

TMEM55B — Transmembrane Protein 55B

PIEZO1 — Piezo Type Mechanosensitive Ion Channel Component 1

PIEZO2 — Piezo Type Mechanosensitive Ion Channel Component 2

PIEZO2 Protein

Cholinergic Neurons (Basal Forebrain)

TRPC1 Gene

Ependymal Cells in Normal Pressure Hydrocephalus