concept

ZO1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ZO1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

177Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	ZO1
Key Genes/Proteins	PPARG, CMVS
Related Diseases	Als, Stroke, Diabetes, ALS
Linked Hypotheses	4 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    ZO1["ZO1"]
    style ZO1 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    ZO1 -->|"expressed in"| Als["Als"]
    ZO1 -->|"activates"| CLDN5([CLDN5])
    ZO1 -->|"expressed in"| IL8([IL8])
    ZO1 -->|"expressed in"| Innate_Immunity["Innate Immunity"]
    ZO1 -->|"activates"| Toll_Like_Receptor["Toll-Like Receptor"]
    ZO1 -->|"expressed in"| Immune_Response["Immune Response"]
    ZO1 -->|"implicated in"| neurodegeneration["neurodegeneration"]
    ZO1 -->|"involved_in"| Blood_brain_barrier["Blood-brain barrier"]
    ZO1 -.->|"biomarker for"| Corneal_epithelium["Corneal epithelium"]
    Byf{"Byf"} -->|"upregulates"| ZO1
    Nobiletin["Nobiletin"] -->|"upregulates"| ZO1
    h_6c83282d["h-6c83282d"] -->|"targets"| ZO1
    PPARG([PPARG]) -->|"upregulates"| ZO1
    CMVS([CMVS]) -->|"activates"| ZO1
    BYF{"BYF"} -->|"activates"| ZO1
    GAL([GAL]) -->|"activates"| ZO1
    CYTOKINES([CYTOKINES]) -->|"activates"| ZO1
    TLR2([TLR2]) -->|"activates"| ZO1
    OCLN([OCLN]) -->|"activates"| ZO1

Outgoing (109)

Target	Relation	Type	Str
Blood-Brain Barrier	biomarker_for	brain_region	0.85
Als	expressed_in	disease	0.65
Stroke	activates	disease	0.65
Als	activates	disease	0.65
Diabetes	activates	disease	0.65
ALS	activates	disease	0.65
CLDN5	activates	gene	0.60
neurodegeneration	implicated_in	disease	0.60
SDHA	regulates	gene	0.60
OCLN	activates	gene	0.60
CLDN5, OCLN	activates	gene	0.60
JNK	activates	gene	0.60
ACTB	regulates	gene	0.60
UBC	regulates	gene	0.60
TNF	activates	gene	0.60
IL8	expressed_in	gene	0.60
Innate Immunity	expressed_in	pathway	0.60
Toll-Like Receptor	activates	pathway	0.60
Immune Response	expressed_in	pathway	0.60
Mapk	activates	pathway	0.60
Endothelial	expressed_in	cell_type	0.60
Epithelial	expressed_in	cell_type	0.60
STROKE	activates	gene	0.60
ERK	activates	gene	0.60
IL-1	activates	gene	0.60
Il-1	activates	protein	0.60
Ras	activates	protein	0.60
App	activates	protein	0.60
endothelial cells	expressed_in	cell_type	0.60
ALZHEIMER	expression	disease	0.60
Blood-brain barrier	involved_in	pathway	0.60
Corneal epithelium	biomarker_for	tissue	0.60
Cortex	expressed_in	brain_region	0.55
blood-brain barrier	participates_in	pathway	0.55
neurodegeneration	associated_with	disease	0.53
CLDN1	interacts_with	gene	0.53
OCLN	interacts_with	gene	0.53
MLCK	interacts_with	gene	0.53
Gut-brain axis / microbiome signaling	participates_in	pathway	0.46
GLP1R	co_discussed	gene	0.40
CLDN1	co_discussed	gene	0.40
SNCA	co_discussed	gene	0.40
BDNF	co_discussed	gene	0.40
OCLN	co_discussed	gene	0.40
HSPA1A	co_discussed	gene	0.40
TH	co_discussed	gene	0.40
AHR	co_discussed	gene	0.40
NLRP3	co_discussed	gene	0.40
DNMT1	co_discussed	gene	0.40
CASP1	co_discussed	gene	0.40

Incoming (68)

Source	Relation	Type	Str
Byf	upregulates	drug	0.95
Betulinic Acid	upregulates	compound	0.95
h-6c83282d	targets_gene	hypothesis	0.90
Nobiletin	upregulates	compound	0.85
h-6c83282d	targets	hypothesis	0.80
PPARG	upregulates	gene	0.80
Endoplasmic Reticulum Stress	downregulates	process	0.80
CMVS	activates	protein	0.72
BYF	activates	drug	0.64
GAL	activates	gene	0.60
TLR2	activates	gene	0.60
OCLN	activates	gene	0.60
CLDN5	activates	gene	0.60
UBC	regulates	gene	0.60
ACTB	regulates	gene	0.60
GAPDH	regulates	gene	0.60
JNK	activates	gene	0.60
TNF	activates	gene	0.60
SDHA	regulates	gene	0.60
CLDN5	expressed_in	gene	0.60
OCLN	expressed_in	gene	0.60
CLDN5	binds_to	gene	0.60
OCLN	binds_to	gene	0.60
CYTOKINES	activates	gene	0.60
STROKE	activates	gene	0.60
ERK	activates	gene	0.60
IL-1	activates	gene	0.60
GENES	regulates	gene	0.60
AND	activates	gene	0.60
MAPK	activates	gene	0.60
AND	expressed_in	gene	0.60
BMSC-EVs	protects_against	cell_type	0.60
BEC-EVs	protects_against	cell_type	0.60
CLDN5	co_expressed_with	protein	0.60
OCLN	co_expressed_with	protein	0.60
KLF11	regulates	protein	0.60
CAVEOLIN-1	regulates	protein	0.60
AMPK	activates	pathway	0.60
CLDN1	regulates	gene	0.55
OCLN	regulates	gene	0.55
CLDN1	activates	gene	0.55
CLDN1	co_mentioned	gene	0.55
CLDN1	expressed_in	gene	0.55
CLDN1	interacts_with	gene	0.53
OCLN	interacts_with	gene	0.53
MLCK	interacts_with	gene	0.53
PYCARD	debate_co_mention	gene	0.45
SNCA	debate_co_mention	gene	0.45
TGFB1	debate_co_mention	gene	0.45
TLR4	debate_co_mention	gene	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 20 hypotheses Top: 0.617

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ZO1

Understanding Entity Pages

Wiki Pages (20)

Section 182: Microbiome Metabolomics and SCFA Therapy in CBS/PSP

MLCK Gene

Neurovascular Unit Dysfunction Hypothesis in Parkinson's Disease

Microbiome Metabolomics and SCFA Therapy for CBS/PSP

CING1 Gene

Blarcamesine (ALX-001)

Section 123: Microbiome-Gut-Brain Axis Interventions for CBS/PSP

Alpha-Synuclein Immunotherapy

Caveolin-1

Parkinson Basal Ganglia Circuit

PARKIN Gene

Parkin Protein

rock-inhibitor-therapy-parkinsons

Akkermansia muciniphila in CNS Disorders

Alpha-Synuclein Reduction Therapies for Neurodegenerative Diseases

AbbVie BRAIN Platform — Blood-Brain Barrier Delivery Technology

Alpha-Synuclein Aggregation Inhibitors