gene

atp5b

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about atp5b: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections
0Hypotheses
0Analyses
5Outgoing
9Incoming

No summary available yet. View on Wiki →

🧬 Gene Info
Gene SymbolATP5B
Chromosome12p13.33
Protein TypeGene
Functionis a central hallmark of neurodegenerative diseases, and ATP5B plays a critical role in this pathology.
Molecular Weight56 kDa
Amino Acids529 aa
Exons13
GeneCardsATP5B
Human Protein AtlasATP5B
Associated Diseasesneurodegeneration
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (7)

Knowledge base pages for this entity

atp5b

gene · 2688 words

Proteomics of Progressive Supranuclear Palsy

mechanism · 1676 words

ATP5A1 Gene

gene · 1028 words

ATP5A1 Protein

protein · 666 words

ATP5B Protein

protein · 619 words

Pathway Diagram

flowchart TD
    N0["ATP5B"]
    N1["Cirrhosis"]
    N0 -.->|"inhibits"| N1
    N2["Hepatitis"]
    N0 -->|"activates"| N2
    N3["CHOP"]
    N3 -.->|"inhibits"| N0
    N4["INSULIN RESISTANCE"]
    N4 -.->|"inhibits"| N0
    N5["AND"]
    N5 -.->|"inhibits"| N0
    N6["MITOCHONDRIA"]
    N6 -->|"activates"| N0
    N7["ROS"]
    N7 -->|"activates"| N0
    N8["neurodegeneration"]
    N0 -->|"implicated in"| N8

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
    class N1 disease
    class N2 disease
    class N3 gene
    class N4 gene
    class N5 gene
    class N6 gene
    class N7 gene

Outgoing (5)

TargetRelationTypeStr
Cirrhosisinhibitsdisease0.65
Hepatitisactivatesdisease0.65
SIRT1activatesgene0.60
TFAMactivatesgene0.60
benchmark_ot_ad_answer_key:ATP5Bdata_indataset_row0.00

Incoming (9)

SourceRelationTypeStr
CHOPinhibitsgene0.60
resveratroltargetsdrug0.60
INSULIN RESISTANCEinhibitsgene0.60
ANDinhibitsgene0.60
MITOCHONDRIAactivatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found