Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about atp5b: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ATP5B |
| Chromosome | 12p13.33 |
| Protein Type | Gene |
| Function | is a central hallmark of neurodegenerative diseases, and ATP5B plays a critical role in this pathology. |
| Molecular Weight | 56 kDa |
| Amino Acids | 529 aa |
| Exons | 13 |
| GeneCards | ATP5B |
| Human Protein Atlas | ATP5B |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["ATP5B"]
N1["Cirrhosis"]
N0 -.->|"inhibits"| N1
N2["Hepatitis"]
N0 -->|"activates"| N2
N3["CHOP"]
N3 -.->|"inhibits"| N0
N4["INSULIN RESISTANCE"]
N4 -.->|"inhibits"| N0
N5["AND"]
N5 -.->|"inhibits"| N0
N6["MITOCHONDRIA"]
N6 -->|"activates"| N0
N7["ROS"]
N7 -->|"activates"| N0
N8["neurodegeneration"]
N0 -->|"implicated in"| N8
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
class N1 disease
class N2 disease
class N3 gene
class N4 gene
class N5 gene
class N6 gene
class N7 gene| Target | Relation | Type | Str |
|---|---|---|---|
| Cirrhosis | inhibits | disease | 0.65 |
| Hepatitis | activates | disease | 0.65 |
| SIRT1 | activates | gene | 0.60 |
| TFAM | activates | gene | 0.60 |
| benchmark_ot_ad_answer_key:ATP5B | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CHOP | inhibits | gene | 0.60 |
| resveratrol | targets | drug | 0.60 |
| INSULIN RESISTANCE | inhibits | gene | 0.60 |
| AND | inhibits | gene | 0.60 |
| MITOCHONDRIA | activates | gene | 0.60 |
| ROS | activates | gene | 0.60 |
| AMPK | activates | gene | 0.60 |
| ATP | activates | gene | 0.60 |
| benchmark_ot_ad_answer_key:ATP5B | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||