disease

Cirrhosis

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Cirrhosis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

473Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Cirrhosis is a disease characterized by neurodegeneration research. Key relationships include: therapeutic target, associated with, activates. Associated with Aging, Als, Alzheimer. Connected to 330 entities in the SciDEX knowledge graph.

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Disease Info

Associated Genes	TREM2, AKT, CEBPB, CYP1A2, CYP3A4, EGF, EGFR, ERCC3
KG Connections	448 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Cirrhosis["Cirrhosis"] -->|"activates"| Pi3K["Pi3K"]
    Cirrhosis["Cirrhosis"] -->|"activates"| Akt["Akt"]
    Cirrhosis["Cirrhosis"] -->|"activates"| Mtor["Mtor"]
    Cirrhosis["Cirrhosis"] -->|"therapeutic target"| Mtor_1["Mtor"]
    Cirrhosis["Cirrhosis"] -->|"therapeutic target"| Autophagy["Autophagy"]
    Cirrhosis["Cirrhosis"] -->|"therapeutic target"| Mapk["Mapk"]
    TREM2["TREM2"] -->|"associated"| Cirrhosis["Cirrhosis"]
    OCLN["OCLN"] -->|"expressed in"| Cirrhosis["Cirrhosis"]
    EGF["EGF"] -->|"activates"| Cirrhosis["Cirrhosis"]
    CYP3A4["CYP3A4"] -->|"activates"| Cirrhosis["Cirrhosis"]
    style Cirrhosis fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (204)

Target	Relation	Type	Str
Hepatitis	associated_with	disease	1.00
Fibrosis	associated_with	disease	1.00
Fibrosis	causes	disease	0.95
Carcinoma	associated_with	disease	0.85
Fibrosis	therapeutic_target	disease	0.85
Als	biomarker_for	disease	0.85
Fibrosis	biomarker_for	disease	0.85
Oxidative Stress	therapeutic_target	pathway	0.80
Inflammation	associated_with	disease	0.75
Inflammation	therapeutic_target	disease	0.75
Fibrosis	activates	disease	0.75
Hepatocellular Carcinoma	associated_with	disease	0.75
Hypertension	causes	disease	0.75
Inflammation	causes	disease	0.75
Fibrosis	implicated_in	disease	0.75
Aging	implicated_in	disease	0.75
Hepatitis	implicated_in	disease	0.75
Diabetes	associated_with	disease	0.75
Als	associated_with	disease	0.75
Hepatitis	biomarker_for	disease	0.75
Hepatocellular Carcinoma	risk_factor_for	disease	0.75
Mtor	therapeutic_target	pathway	0.70
Autophagy	therapeutic_target	pathway	0.70
Oxidative Stress	activates	pathway	0.70
Lipid Metabolism	therapeutic_target	pathway	0.70
Metabolic Syndrome	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Inflammation	activates	disease	0.65
Inflammation	contributes_to	disease	0.65
Autoimmune	contributes_to	disease	0.65
Cancer	causes	disease	0.65
Fibrosis	treats	disease	0.65
Infection	associated_with	disease	0.65
Hepatocellular Carcinoma	causes	disease	0.65
Als	causes	disease	0.65
Carcinoma	causes	disease	0.65
Hepatitis	causes	disease	0.65
Als	treats	disease	0.65
Nafld	treats	disease	0.65
Type 2 Diabetes	associated_with	disease	0.65
Fibrosis	regulates	disease	0.65
Als	therapeutic_target	disease	0.65
Infection	biomarker_for	disease	0.65
Hepatitis	treats	disease	0.65
Pi3K	activates	pathway	0.60
Akt	activates	pathway	0.60
Mtor	activates	pathway	0.60
Mapk	therapeutic_target	pathway	0.60

Incoming (269)

Source	Relation	Type	Str
Non-Alcoholic Fatty Liver Disease	causes	disease	0.90
INFLAMMATION	associated_with	gene	0.85
CANCER	associated_with	gene	0.85
INFLAMMATION	activates	gene	0.85
OXIDATIVE STRESS	therapeutic_target	gene	0.85
INFLAMMATION	therapeutic_target	gene	0.85
INFLAMMATION	causes	gene	0.85
AMPK	therapeutic_target	gene	0.75
MTOR	therapeutic_target	gene	0.75
AUTOPHAGY	therapeutic_target	gene	0.75
MTORC1	therapeutic_target	gene	0.75
APOPTOSIS	therapeutic_target	gene	0.75
OXIDATIVE STRESS	activates	gene	0.75
INFLAMMATION	regulates	gene	0.75
DIABETES MELLITUS	associated_with	gene	0.75
INFLAMMATION	contributes_to	gene	0.75
TNF	regulates	gene	0.75
TNF-Α	regulates	gene	0.75
CYTOKINES	causes	gene	0.75
GENES	treats	gene	0.75
TREM2	associated_with	gene	0.65
OCLN	expressed_in	gene	0.65
EGF	activates	gene	0.65
CYP3A4	activates	gene	0.65
PDK1	activates	gene	0.65
MTOR	activates	gene	0.65
EGFR	activates	gene	0.65
ERCC3	activates	gene	0.65
CEBPB	activates	gene	0.65
CYP1A2	activates	gene	0.65
PI3K	activates	gene	0.65
AKT	activates	gene	0.65
LAMTOR1	therapeutic_target	gene	0.65
PARKIN	inhibits	gene	0.65
PRDX6	inhibits	gene	0.65
MYC	inhibits	gene	0.65
FGF21	therapeutic_target	gene	0.65
FGF19	therapeutic_target	gene	0.65
IDE	activates	gene	0.65
CD36	activates	gene	0.65
TLR4	activates	gene	0.65
Obesity	associated_with	disease	0.65
MICRORNAS	therapeutic_target	gene	0.65
MIRNAS	therapeutic_target	gene	0.65
CXCL10	therapeutic_target	gene	0.65
AKT	associated_with	gene	0.65
CEBPB	associated_with	gene	0.65
CYP1A2	associated_with	gene	0.65
CYP3A4	associated_with	gene	0.65
EGF	associated_with	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Cirrhosis

Understanding Entity Pages

Summary

Wiki Pages (20)

nf1-protein

Liver-Brain Neurodegeneration Axis

Manganese-Related Neurodegeneration (Manganism)

NNMT Gene

atp5b

ATP7B

zellweger-spectrum-disorders

wilsons-disease

vasopressin-v1a-neurons

Metal Ion Toxicity in Neurodegeneration

C1S Gene

Wilson's Disease Treatment

MRC1 — Mannose Receptor C Type 1

NOTCH3 Protein

Wilson's Disease Copper Dysregulation Mechanistic Pathway

NOTCH3 — Notch Receptor 3

Wilson's Disease

Liver-Brain Axis - Hepatic Enzyme-Mediated BBB Protection