concept

RESVERATROL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RESVERATROL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

309Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	RESVERATROL
Key Genes/Proteins	TAU, CDK5, RELA, ROS, STAT3, SOD2
Related Diseases	NEURODEGENERATION, AUTOPHAGY, PROTEIN AGGREGATION, PYROPTOSIS
Related Pathways	INSULIN SIGNALING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    RESVERATROL["RESVERATROL"]
    RESVERATROL -.protects against.-> UVA_Induced_Photoaging["UVA-Induced Photoaging"]
    RESVERATROL -->|"activates"| SIRT1["SIRT1"]
    RESVERATROL -->|"reduces_phosphorylation_of"| IRS1["IRS1"]
    RESVERATROL -->|"mediates"| AMPK_Phosphorylation["AMPK Phosphorylation"]
    RESVERATROL -->|"activates"| insulin_signaling["insulin signaling"]
    RESVERATROL -->|"inhibits"| Apoptosis["Apoptosis"]
    RESVERATROL -->|"inhibits"| Collagen_Fiber_Degradation["Collagen Fiber Degradation"]
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -.biomarker for.-> RESVERATROL
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"target for"| RESVERATROL
    FOXO1["FOXO1"] -->|"activates"| RESVERATROL
    FIBROBLASTS["FIBROBLASTS"] -->|"activates"| RESVERATROL
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| RESVERATROL
    CELL_CYCLE["CELL CYCLE"] -->|"activates"| RESVERATROL
    APOPTOSIS["APOPTOSIS"] -->|"activates"| RESVERATROL

Outgoing (199)

Target	Relation	Type	Str
TAU	modulates	protein	0.80
CDK5	modulates	gene	0.75
RELA	treats	gene	0.70
ROS	phosphorylates	gene	0.65
TAU	phosphorylates	gene	0.65
STAT3	targets	gene	0.65
SOD2	regulates	gene	0.65
MICROGLIA	targets	cell_type	0.65
MICROGLIA	inhibits	cell_type	0.65
NEURODEGENERATION	protects_against	phenotype	0.65
AUTOPHAGY	treats	phenotype	0.65
AUTOPHAGY	regulates	phenotype	0.65
PROTEIN AGGREGATION	treats	phenotype	0.65
PYROPTOSIS	activates	phenotype	0.65
INSULIN SIGNALING	treats	pathway	0.65
MAPK	inhibits	gene	0.65
SIRT3	protects_against	gene	0.65
SIRT3	activates	gene	0.65
SIRT3	inhibits	gene	0.65
HISTONE DEACETYLATION	activates	phenotype	0.60
SIRT1	expressed_in	gene	0.55
MTOR	associated_with	gene	0.50
TFEB	associated_with	gene	0.50
CANCER	associated_with	disease	0.50
HUNTINGTON	associated_with	disease	0.50
HUNTINGTIN	associated_with	protein	0.50
NEURONS	associated_with	cell_type	0.50
APP	associated_with	gene	0.50
RELA	associated_with	gene	0.50
STROKE	associated_with	disease	0.50
MACROPHAGES	associated_with	cell_type	0.50
FOXO1	associated_with	gene	0.45
SOD2	associated_with	gene	0.45
AUTOPHAGY	associated_with	phenotype	0.45
AMPK	associated_with	gene	0.45
APOPTOSIS	associated_with	phenotype	0.45
ROS	associated_with	phenotype	0.45
DONEPEZIL	associated_with	drug	0.45
TAU	associated_with	protein	0.45
CURCUMIN	associated_with	drug	0.45
TREM2	associated_with	gene	0.45
SIRT1	associated_with	gene	0.45
TGFB1	associated_with	gene	0.45
HMGB1	associated_with	gene	0.45
STING	associated_with	gene	0.45
AKT	associated_with	gene	0.45
MACROPHAGE	associated_with	cell_type	0.45
MICROGLIA	associated_with	cell_type	0.45
APOE	associated_with	gene	0.45
SOD1	associated_with	gene	0.45

Incoming (110)

Source	Relation	Type	Str
AMPK	phosphorylates	gene	0.65
NEURON	phosphorylates	cell_type	0.65
ALZHEIMER	treats	disease	0.65
ALZHEIMER'S DISEASE	treats	disease	0.65
PARKIN	treats	gene	0.65
PARKINSON	treats	disease	0.65
PARKINSON'S DISEASE	treats	disease	0.65
PARKIN	expressed_in	gene	0.65
AKT	targets	gene	0.65
PI3K	targets	gene	0.65
RAGE	targets	gene	0.65
ENDOTHELIAL	targets	cell_type	0.65
MACROPHAGE	targets	cell_type	0.65
PLP1	interacts_with	gene	0.65
FERROPTOSIS	treats	phenotype	0.65
PARKINSON'S DISEASE	biomarker_for	disease	0.50
ALZHEIMER'S DISEASE	therapeutic_target	disease	0.50
CELL SURVIVAL	associated_with	concept	0.50
SOD2	activates	gene	0.50
Autophagy	activates	process	0.50
aging	activates	phenotype	0.50
aging	associated_with	phenotype	0.50
FIBROBLASTS	associated_with	concept	0.50
apoptosis	activates	process	0.50
Reactive Oxygen Species	activates	process	0.50
TGFB1	regulates	gene	0.50
TNFA	regulates	gene	0.50
C3AR1	regulates	gene	0.50
Nf-Kb	regulates	pathway	0.50
PP2A	activates	gene	0.50
oxidative stress	activates	phenotype	0.50
ALZHEIMER	associated_with	gene	0.50
Alzheimer'S Disease	associated_with	disease	0.50
Parkinson's Disease	associated_with	disease	0.50
disease	associated_with	disease	0.50
ALZHEIMER'S	associated_with	concept	0.50
PARKINSON'S	associated_with	concept	0.50
ALZHEIMER	expressed_in	gene	0.50
PARKINSON	expressed_in	gene	0.50
Alzheimer'S Disease	expressed_in	disease	0.50
Parkinson's Disease	expressed_in	disease	0.50
disease	expressed_in	disease	0.50
ALZHEIMER'S	expressed_in	concept	0.50
PARKINSON'S	expressed_in	concept	0.50
GENE EXPRESSION	expressed_in	concept	0.50
Pi3K	associated_with	pathway	0.50
STAT3	associated_with	gene	0.50
RAGE	associated_with	gene	0.50
CASP3	associated_with	gene	0.50
microglia	regulates	cell_type	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

RESVERATROL

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Parkinson's Disease

CBS/PSP Supplements Guide

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Neuroresilience Mechanisms and Evidence

Therapeutics

NPM1 Gene

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

CBS/PSP Treatment Rankings

NRF2 Oxidative Stress Pathway

Mitochondrial Quality Control

Autophagy Mechanisms

Blood-Brain Barrier Dysfunction in Neurodegeneration

Mitophagy Pathway in Neurodegeneration

Melatonin for Tauopathy: Comprehensive Evidence Synthesis

protective-strategies-cbs-psp

Epigenetic Dysregulation in Neurodegeneration