gene

CHOP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHOP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

905Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

CHOP is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, associated with. Associated with AD, ALI, ALS. Connected to 421 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CHOP
Chromosome	12q13.12
Protein Type	Protein
Function	is a leucine zipper transcription factor that functions as a critical regulator of cellular stress responses, particularly during endoplasmic reticulum (ER) stress and the unfolded protein response...
Pathways	Apoptosis, Epigenetic, Er Stress, Ferroptosis, Glycolysis
UniProt ID	Search UniProt
GeneCards	CHOP
Human Protein Atlas	CHOP
Associated Diseases	AD, ALI, Als, Alzheimer, Cancer
Known Drugs/Compounds	rapamycin
Interactions	ABCD3, AKT, ALS, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE
KG Connections	904 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: CHOP — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CHOP["CHOP"] -->|"Interacts With"| Dementia["Dementia"]
    CHOP["CHOP"] -->|"Interacts With"| Cardiovascular["Cardiovascular"]
    CHOP["CHOP"] -->|"Interacts With"| Als["Als"]
    CHOP["CHOP"] -->|"Interacts With"| Alzheimer["Alzheimer"]
    CHOP["CHOP"] -->|"Interacts With"| Parkinson["Parkinson"]
    CHOP["CHOP"] -->|"Interacts With"| Ms["Ms"]
    CHOP["CHOP"] -->|"Associated With"| Lymphoma["Lymphoma"]
    CHOP["CHOP"] -->|"Associated With"| Inflammation["Inflammation"]
    CAT["CAT"] -->|"Interacts With"| CHOP["CHOP"]
    OPTN["OPTN"] -->|"Interacts With"| CHOP["CHOP"]
    DNM1L["DNM1L"] -->|"Interacts With"| CHOP["CHOP"]
    CANX["CANX"] -->|"Interacts With"| CHOP["CHOP"]
    LGALS3["LGALS3"] -->|"Interacts With"| CHOP["CHOP"]
    style CHOP fill:#8d4900,color:#e0e0e0
    style Dementia fill:#b71c1c,color:#e0e0e0
    style Cardiovascular fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Alzheimer fill:#b71c1c,color:#e0e0e0
    style Parkinson fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Lymphoma fill:#b71c1c,color:#e0e0e0
    style Inflammation fill:#b71c1c,color:#e0e0e0
    style CAT fill:#8d4900,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0
    style DNM1L fill:#8d4900,color:#e0e0e0
    style CANX fill:#8d4900,color:#e0e0e0
    style LGALS3 fill:#8d4900,color:#e0e0e0

Outgoing (555)

Target	Relation	Type	Str
CHOP	encodes	protein	0.00
Als	activates	disease	0.85
Er Stress	activates	pathway	0.80
Inflammation	activates	disease	0.75
Neurodegeneration	activates	disease	0.75
Cancer	inhibits	disease	0.75
Unfolded Protein Response	activates	pathway	0.70
Apoptosis	inhibits	pathway	0.70
neural stem cells	activates	cell_type	0.70
Oligodendrocyte death	causes	mechanism	0.70
Fibrosis	expressed_in	disease	0.65
Als	inhibits	disease	0.65
Neuropathy	associated_with	disease	0.65
Lymphoma	expressed_in	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Tumor	expressed_in	disease	0.65
Cancer	activates	disease	0.65
Ftd	interacts_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Ms	regulates	disease	0.65
Hepatitis	inhibits	disease	0.65
Tumor	activates	disease	0.65
Alzheimer	inhibits	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Als	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Lymphoma	therapeutic_target	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Autoimmune	activates	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Inflammation	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Ms	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Parkinson	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Carcinoma	regulates	disease	0.65
Als	regulates	disease	0.65
Tumor	regulates	disease	0.65
Cirrhosis	inhibits	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Dementia	interacts_with	disease	0.65
Als	interacts_with	disease	0.65

Incoming (350)

Source	Relation	Type	Str
CHOP	encodes	gene	0.00
ATG2A-G433A	upregulates	variant	0.85
BIP	activates	gene	0.70
NEURODEGENERATION	activates	gene	0.70
CANCER	inhibits	gene	0.70
APOE4	activates	gene	0.65
PERK	activates	gene	0.60
PI3K	inhibits	gene	0.60
P62	inhibits	gene	0.60
BCL2	inhibits	gene	0.60
LC3	inhibits	gene	0.60
BCL2	activates	entity	0.60
BAX	activates	gene	0.60
GBA1	activates	gene	0.60
ABCD3	activates	entity	0.60
BCL2L13	activates	entity	0.60
BECN1	activates	entity	0.60
PARKINSON	interacts_with	gene	0.60
PROTEASOME INHIBITION	inhibits	gene	0.60
JAK	therapeutic_target	gene	0.60
CYTOKINES	therapeutic_target	gene	0.60
PROINFLAMMATORY CYTOKINES	therapeutic_target	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
DIABETES MELLITUS	therapeutic_target	gene	0.60
IL-6	therapeutic_target	gene	0.60
ERK	biomarker_for	gene	0.60
INFLAMMATION	activates	gene	0.60
TNF-Α	activates	gene	0.60
NIX	interacts_with	gene	0.60
BAX	inhibits	gene	0.60
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60
RETREG1	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
MITOPHAGY	interacts_with	gene	0.60
HIF	interacts_with	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
PRESENILIN	interacts_with	gene	0.60
ASTROCYTES	expressed_in	gene	0.60
ATF4	associated_with	gene	0.60
GCASE	activates	gene	0.60
AMBRA1	regulates	gene	0.60
ATM	regulates	gene	0.60
BCL2	regulates	gene	0.60
BCL2L13	regulates	gene	0.60
BECN1	regulates	gene	0.60
BNIP3L	regulates	gene	0.60
CALCOCO2	regulates	gene	0.60
CAT	regulates	gene	0.60
BDNF	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
eIF2alpha Dephosphorylation Threshold Prevents Pro-Apoptotic	0.445	-	What is the minimum effective dose of tr

Mentioning Analyses (1)

Scientific analyses that reference this entity

What specific gene expression signatures in aging mouse white matter predict hum

neurodegeneration | 2026-04-11 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The debate initiated investigation into white matter aging and myelin changes bu

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

Related Research

Hypotheses and analyses mentioning CHOP in their description or question text

No additional research found