drug

ambroxol

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ambroxol: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

10Connections

0Hypotheses

2Analyses

10Outgoing

0Incoming

0Experiments

2Debates

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💊 Drug Info

Name	ambroxol
Key Genes/Proteins	GCase, glucocerebrosidase
Related Pathways	alpha_synuclein_aggregation

Wiki Pages (1)

Knowledge base pages for this entity

ambroxol-aspro-pd

clinical_trial · 2976 words

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Pathway Diagram

flowchart TD
    N0["Ambroxol"]
    N1["GCASE"]
    N0 -->|"activates"| N1
    N2["alpha-Synuclein Oligomer Accumulation"]
    N0 -->|"associated with"| N2
    N3["GBA1"]
    N0 -->|"targets"| N3
    N4["Parkinson Disease"]
    N0 -->|"treats"| N4

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
    class N3 protein
    class N4 disease

Outgoing (10)

Target	Relation	Type	Str
alpha_synuclein_aggregation	inhibits	mechanism	0.90
GCASE	activates	enzyme	0.90
α-Synuclein Oligomer Accumulation	associated_with	process	0.90
GBA1	targets	protein	0.90
blood brain barrier	associated_with	brain_region	0.90
Parkinson's disease	modulates	unknown	0.80
Parkinson Disease	treats	disease	0.75
GCase	activates	protein	0.70
glucocerebrosidase	activates	protein	0.70
glucocerebrosidase	modulates	protein	0.70

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

What is the therapeutic window between GCS inhibition efficacy and systemic toxi

neurodegeneration | 2026-04-11 | 0 hypotheses

GBA-Synuclein Loop Therapeutics for PD

neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.525

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

The debate identified systemic toxicity as a major concern for glucosylceramide

closed · Rounds: 4 · Score: 0.50 · 2026-04-20

How to break the GBA-alpha-synuclein bidirectional loop for Parkinson's Disease

closed · Rounds: 4 · Score: 0.90 · 2026-04-06

Related Research

Hypotheses and analyses mentioning ambroxol in their description or question text

No additional research found