alpha_synuclein_aggregation

Understanding Entity Pages

This page aggregates everything SciDEX knows about alpha_synuclein_aggregation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

A mechanism referenced in 4 knowledge graph relationships. Key connections: causes dopaminergic_neuron_death (mechanism); glucosylceramide_accumulation (mechanism) promotes; inhibits GCase (protein).

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flowchart TD
    N0["Alpha-Synuclein Aggregation"]
    N1["Parkinson's Disease"]
    N0 -->|"causes"| N1
    N2["Mitochondrial Depolarization"]
    N0 -->|"causes"| N2
    N3["Dopaminergic Neurons"]
    N0 -->|"causes"| N3
    N4["ATP Production"]
    N0 -.->|"downregulates"| N4
    N5["Autophagy-Lysosomal Pathway"]
    N0 -->|"involved in"| N5
    N6["Short-Chain Fatty Acids"]
    N6 -->|"modulates"| N0
    N7["Piperine"]
    N7 -.->|"inhibits"| N0
    N8["D-520"]
    N8 -.->|"suppresses"| N0
    N9["Mitochondrial Fragmentation"]
    N0 -->|"causes"| N9
    N10["Neurodegeneration"]
    N0 -->|"causes"| N10
    N11["CNS Inflammation"]
    N0 -->|"causes"| N11
    N12["BMAL1"]
    N12 -.->|"inhibits"| N0
    N13["ceftriaxone"]
    N13 -.->|"inhibits"| N0
    N14["SNCA"]
    N14 -->|"regulates"| N0
    N15["Polyamines"]
    N15 -->|"modulates"| N0

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
    class N1 disease
    class N5 pathway
    class N12 gene
    class N14 gene