concept

GLUCOCEREBROSIDASE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GLUCOCEREBROSIDASE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

30Connections

0Hypotheses

2Analyses

15Outgoing

15Incoming

0Experiments

2Debates

No summary available yet.

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💡 Concept Info

Name	GLUCOCEREBROSIDASE
Key Genes/Proteins	GBA
Related Diseases	Gaucher disease, Parkinson's disease

Pathway Diagram

graph TD
    GLUCOCEREBROSIDASE["GLUCOCEREBROSIDASE"]
    GLUCOCEREBROSIDASE -->|"degrades"| Glucocerebrosides["Glucocerebrosides"]
    GLUCOCEREBROSIDASE -->|"catalyzes"| Sphingolipid_Metabolism["Sphingolipid Metabolism"]
    GLUCOCEREBROSIDASE -->|"treats"| Gaucher_Disease["Gaucher Disease"]
    GLUCOCEREBROSIDASE -->|"regulates"| Lipid_Metabolism["Lipid Metabolism"]
    GLUCOCEREBROSIDASE -->|"regulates"| Lysosomal_Autophagy["Lysosomal Autophagy"]
    GBA["GBA"] -->|"encodes"| GLUCOCEREBROSIDASE
    GBA1["GBA1"] -->|"encodes"| GLUCOCEREBROSIDASE
    Bi_Htfr1["Bi-Htfr1"] -->|"upregulates"| GLUCOCEREBROSIDASE

Outgoing (15)

Target	Relation	Type	Str
Gaucher disease	associated_with	disease	0.95
Glucocerebrosides	degrades	compound	0.95
lysosomal degradation	regulates	pathway	0.90
Parkinson's disease	associated_with	disease	0.90
glucocerebroside	degrades	compound	0.90
Glucosylceramide	regulates	drug	0.90
Gaucher Disease	treats	disease	0.85
Glucocerebrosides	substrate_of	compound	0.85
Sphingolipid Metabolism	regulates	pathway	0.85
Lipid Metabolism	regulates	pathway	0.85
Lysosomal Autophagy	regulates	process	0.80
Alpha-Synuclein Accumulation	associated_with	phenotype	0.70
glucosylceramide	regulates	process	0.70
lysosomal pathways	regulates	pathway	0.70
lysosomal degradation	activates	phenotype	0.70

Incoming (15)

Source	Relation	Type	Str
GBA1	expresses	gene	1.00
GBA	expresses	gene	1.00
GBA	associated_with	gene	1.00
GBA	encodes	gene	0.95
Bi-Htfr1	upregulates	drug	0.93
GBA	associated_with	gene	0.90
23266198	interacts with	paper	0.90
GBA	encodes	gene	0.90
alpha-synuclein	inhibits	protein	0.90
GBA1	associated_with	gene	0.90
alpha_synuclein	inhibits	protein	0.90
Small-molecule stabilizers	targets	drug	0.85
ambroxol	activates	drug	0.70
ambroxol	modulates	drug	0.70
GBA1	encodes	gene	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

GBA-Synuclein Loop Therapeutics for PD

neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.525

GBA-Synuclein Loop: Therapeutic Strategies for Parkinson's Disease

neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.380

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

GBA-Synuclein Loop: Therapeutic Strategies for Parkinson's Disease?

closed · Rounds: 4 · Score: 0.89 · 2026-04-10

How to break the GBA-alpha-synuclein bidirectional loop for Parkinson's Disease

closed · Rounds: 4 · Score: 0.90 · 2026-04-06

Related Research

Hypotheses and analyses mentioning GLUCOCEREBROSIDASE in their description or question text

No additional research found