Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BMPR2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
BMPR2 encodes bone morphogenetic protein receptor type II, a critical regulator of BMP signaling with roles in neuroinflammation, neuronal survival, and neurodegenerative diseases including Alzheimer's and Parkinson's
| Gene Symbol | BMPR2 |
| Full Name | Bone Morphogenetic Protein Receptor Type 2 |
| Chromosome | 2q33.1 |
| Protein Type | Serine/Threonine Kinase |
| Function | encodes a constitutively active type II serine/threonine kinase receptor that plays critical roles in Bone Morphogenetic Protein (BMP) signaling pathways [@uzdens2018]. |
| Primary Expression | astrocytes and regulates their function [@wang2019]: |
| Amino Acids | 1038 aa |
| Pathways | MAPK pathway, MAPK signaling, PI3K |
| UniProt ID | [Q13873](https://www.uniprot.org/uniprot/Q13873) |
| Ensembl ID | ENSG00000153208 |
| OMIM | 600799 |
| GeneCards | BMPR2 |
| Human Protein Atlas | BMPR2 |
| Extracellular domain | Ligand-binding region with cysteine-rich domain |
| Transmembrane domain | Single-pass helix anchoring the receptor |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Interactions | BMPR1A, BMPR1B |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
BMPR2["BMPR2"]
BMPR1B["BMPR1B"]
BMPR1A["BMPR1A"]
neurodegeneration["neurodegeneration"]
BMPR1B -->|"interacts with"| BMPR2
BMPR1A -->|"interacts with"| BMPR2
BMPR2 -->|"implicated in"| neurodegeneration
style BMPR2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
style BMPR1B fill:#1a237e,stroke:#ce93d8,stroke-width:2px,color:#fff
style BMPR1A fill:#1a237e,stroke:#ce93d8,stroke-width:2px,color:#fff
style neurodegeneration fill:#1a1a2e,stroke:#888,stroke-width:2px,color:#fff| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||