Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BMPR1B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | BMPR1B |
| Full Name | Bone Morphogenetic Protein Receptor Type 1B |
| Chromosome | 4q22.3 |
| Protein Type | Receptor |
| Function | BMPR1B (Bone Morphogenetic Protein Receptor Type 1B) is a serine/threonine receptor kinase that transduces signals from bone morphogenetic proteins (BMPs), which are members of the TGF-β superfamily. |
| Primary Expression | various brain regions and has been implicated in neurodegenerative diseases, particularly Parkinson's disease where BM |
| Pathways | TGF-β |
| UniProt ID | O00221 |
| GeneCards | BMPR1B |
| Human Protein Atlas | BMPR1B |
| Associated Diseases | neurodegeneration |
| Interactions | BMP7, BMPR2, ERK1, ERK |
| KG Connections | 18 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
BMPR1B["BMPR1B"]
BMPR2("BMPR2")
BMPR1B -->|"interacts_with"| BMPR2
BMP2(["BMP2"])
BMPR1B -->|"participates_in"| BMP2
BMP4(["BMP4"])
BMPR1B -->|"participates_in"| BMP4
SMAD("SMAD")
BMPR1B -->|"participates_in"| SMAD
TGF_beta(["TGF-beta"])
BMPR1B -->|"participates_in"| TGF_beta
Obesity{"Obesity"}
BMPR1B -->|"inhibits"| Obesity
BMP7["BMP7"]
BMPR1B -->|"activates"| BMP7
Differentiation(["Differentiation"])
BMPR1B -->|"activates"| Differentiation
ERK1["ERK1"]
ERK1 -->|"inhibits"| BMPR1B
ERK["ERK"]
ERK -->|"inhibits"| BMPR1B
neurodegeneration["neurodegeneration"]
BMPR1B -->|"implicated_in"| neurodegeneration| Target | Relation | Type | Str |
|---|---|---|---|
| BMPR2 | interacts_with | protein | 0.90 |
| BMP2 | participates_in | pathway | 0.80 |
| BMP4 | participates_in | pathway | 0.80 |
| TGF-beta | participates_in | pathway | 0.70 |
| SMAD | participates_in | protein | 0.70 |
| Obesity | inhibits | disease | 0.65 |
| BMP7 | activates | gene | 0.60 |
| NOTCH3 | associated_with | gene | 0.60 |
| SMAD1 | associated_with | gene | 0.60 |
| SMAD4 | associated_with | gene | 0.60 |
| TET2 | associated_with | gene | 0.60 |
| Differentiation | activates | pathway | 0.60 |
| TGF-beta signaling | participates_in | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||