CASK

Understanding Entity Pages

This page aggregates everything SciDEX knows about CASK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

CASK is a MAGUK-family scaffolding protein critical for synaptic organization, receptor anchoring, and neuronal development. Associated with neurodevelopmental disorders, Parkinson's disease, and epilepsy.

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flowchart TD
    N0["CASK"]
    N1["SAP97"]
    N0 -->|"binds"| N1
    N2["SNAP-25"]
    N0 -->|"interacts with"| N2
    N3["SNARE"]
    N0 -->|"interacts with"| N3
    N4["calcium signaling"]
    N0 -->|"participates in"| N4
    N5["neurodegeneration"]
    N0 -->|"implicated in"| N5

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    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
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    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
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    classDef phenotype fill:#2a2a1a,stroke:#ffa726,color:#e0e0e0
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    classDef index fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    class N0 protein
    class N1 protein
    class N2 gene
    class N3 gene
    class N4 pathway