Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SNAP-25: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | SNAP |
| Function | Snap 25 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. |
| GeneCards | SNAP |
| Human Protein Atlas | SNAP |
| Interactions | SNARE, HSC70, MUNC18-1, Proteins, SYNTAXIN-1, CASK |
| KG Connections | 51 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
SNAP_25["<b>SNAP-25</b>"]
BACE1["BACE1"]
SNAP_25 -->|"associated with"| BACE1
NEUROGRANIN["NEUROGRANIN"]
SNAP_25 -->|"associated with"| NEUROGRANIN
HO_1["HO-1"]
SNAP_25 -->|"regulates"| HO_1
oxidative_stress["oxidative stress"]
SNAP_25 -->|"regulates"| oxidative_stress
APP_PS1["APP/PS1"]
SNAP_25 -->|"regulates"| APP_PS1
Hippocampus["Hippocampus"]
SNAP_25 -->|"regulates"| Hippocampus
HSC70["HSC70"]
SNAP_25 -->|"interacts with"| HSC70
MUNC18_1["MUNC18-1"]
SNAP_25 -->|"interacts with"| MUNC18_1
Proteins["Proteins"]
SNAP_25 -->|"interacts with"| Proteins
GLUTAMATE["GLUTAMATE"]
SNAP_25 -->|"associated with"| GLUTAMATE
Neuron["Neuron"]
SNAP_25 -->|"associated with"| Neuron
SYNTAXIN_1["SYNTAXIN-1"]
SNAP_25 -->|"activates"| SYNTAXIN_1
Cortex["Cortex"]
SNAP_25 -->|"activates"| Cortex
CEREBRAL_CORTEX["CEREBRAL CORTEX"]
SNAP_25 -->|"activates"| CEREBRAL_CORTEX
SYNUCLEIN["SYNUCLEIN"]
SNAP_25 -->|"associated with"| SYNUCLEIN
__SYNUCLEIN["alpha-SYNUCLEIN"]
SNAP_25 -->|"associated with"| __SYNUCLEIN
CALCINEURIN["CALCINEURIN"]
SNAP_25 -->|"associated with"| CALCINEURIN
NEURONS["NEURONS"]
SNAP_25 -->|"associated with"| NEURONS
Exocytosis["Exocytosis"]
SNAP_25 -->|"interacts with"| Exocytosis
Synaptic_Plasticity["Synaptic Plasticity"]
SNAP_25 -->|"interacts with"| Synaptic_Plasticity
CALCINEURIN["CALCINEURIN"]
SNAP_25 -->|"expressed in"| CALCINEURIN
NEURONS["NEURONS"]
SNAP_25 -->|"expressed in"| NEURONS
SYNAPTOPHYSIN["SYNAPTOPHYSIN"]
SYNAPTOPHYSIN -->|"associated with"| SNAP_25
ADAM10["ADAM10"]
ADAM10 -->|"regulates"| SNAP_25
NRF2["NRF2"]
NRF2 -->|"regulates"| SNAP_25
STXBP1["STXBP1"]
STXBP1 -->|"interacts with"| SNAP_25
SCHIZOPHRENIA["SCHIZOPHRENIA"]
SCHIZOPHRENIA -->|"associated with"| SNAP_25
SCHIZOPHRENIA["SCHIZOPHRENIA"]
SCHIZOPHRENIA -->|"inhibits"| SNAP_25
VAMP2["VAMP2"]
VAMP2 -->|"activates"| SNAP_25
SNARE["SNARE"]
SNARE -->|"activates"| SNAP_25| Target | Relation | Type | Str |
|---|---|---|---|
| Synaptic Dysfunction | biomarker_for | mechanism | 0.80 |
| oxidative stress response | participates_in | pathway | 0.75 |
| DAM microglia | expressed_in | cell_type | 0.55 |
| neurons | expressed_in | cell_type | 0.55 |
| neurodegeneration | protects_against | disease | 0.55 |
| TNF | biomarker_for | gene | 0.55 |
| SNARE | interacts_with | gene | 0.55 |
| calcium signaling | participates_in | pathway | 0.55 |
| BACE1 | associated_with | gene | 0.50 |
| NEUROGRANIN | associated_with | protein | 0.50 |
| HO-1 | regulates | protein | 0.50 |
| oxidative stress | regulates | phenotype | 0.50 |
| APP/PS1 | regulates | concept | 0.50 |
| Hippocampus | regulates | entity | 0.50 |
| HSC70 | interacts_with | protein | 0.50 |
| MUNC18-1 | interacts_with | protein | 0.50 |
| Proteins | interacts_with | protein | 0.50 |
| GLUTAMATE | associated_with | concept | 0.50 |
| Neuron | associated_with | cell_type | 0.50 |
| SYNTAXIN-1 | activates | protein | 0.50 |
| Cortex | activates | brain_region | 0.50 |
| CEREBRAL CORTEX | activates | concept | 0.50 |
| SYNUCLEIN | associated_with | concept | 0.50 |
| α-SYNUCLEIN | associated_with | concept | 0.50 |
| CALCINEURIN | associated_with | protein | 0.50 |
| NEURONS | associated_with | concept | 0.50 |
| Exocytosis | interacts_with | pathway | 0.50 |
| Synaptic Plasticity | interacts_with | pathway | 0.50 |
| CALCINEURIN | expressed_in | protein | 0.50 |
| NEURONS | expressed_in | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PSD-95 | biomarker_for | gene | 0.65 |
| PSD-95 | protects_against | gene | 0.55 |
| MCU | biomarker_for | gene | 0.55 |
| CASK | interacts_with | gene | 0.55 |
| SYNAPTOPHYSIN | associated_with | gene | 0.50 |
| ADAM10 | regulates | protein | 0.50 |
| NRF2 | regulates | gene | 0.50 |
| STXBP1 | interacts_with | gene | 0.50 |
| SCHIZOPHRENIA | associated_with | disease | 0.50 |
| SCHIZOPHRENIA | inhibits | disease | 0.50 |
| VAMP2 | activates | gene | 0.50 |
| SNARE | activates | protein | 0.50 |
| TREM2 | associated_with | gene | 0.50 |
| Neuroinflammation | associated_with | process | 0.50 |
| YKL-40 | associated_with | protein | 0.50 |
| NEUROFILAMENT LIGHT CHAIN | associated_with | protein | 0.50 |
| PSD-95 | activates | protein | 0.50 |
| SCHIZOPHRENIA | interacts_with | disease | 0.50 |
| NRG1 | interacts_with | gene | 0.50 |
| SNARE | associated_with | protein | 0.50 |
| SNAP25 | interacts_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||