Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SAP97: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | SAP97 |
| Full Name | Synapse-Associated Protein 97 |
| Aliases | Page for SAP97 |
| Chromosome | 3q29 |
| Protein Type | Kinase |
| Function | SAP97 (also known as DLG1) is a member of the membrane-associated guanylate kinase (MAGUK) family of scaffold proteins. |
| Subcellular Localization | and functional properties, with implications for synaptic function and neuronal health |
| Pathways | PI3K, mTOR, mtor, MTOR |
| Ensembl ID | ENSG00000150048 |
| GeneCards | SAP97 |
| Human Protein Atlas | SAP97 |
| PSD-95 | Related MAGUK scaffold protein with overlapping synaptic functions |
| GKAP/SAPAP | Binding partner mediating SAP97 interactions with PSD scaffolds |
| Stargazin/TARP | AMPA receptor auxiliary subunit regulated by SAP97 |
| Postsynaptic Density | Synaptic protein complex organized by SAP97 |
| Associated Diseases | schizophrenia |
| Interactions | GluA1, MAP1B, PSD-95 |
| KG Connections | 10 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
SAP97["<b>SAP97</b>"]
NR2A["NR2A"]
SAP97 -->|"binds"| NR2A
GluA1["GluA1"]
SAP97 -->|"interacts with"| GluA1
neuropathic_pain{"neuropathic pain"}
SAP97 -->|"contributes to"| neuropathic_pain
schizophrenia{"schizophrenia"}
SAP97 -->|"associated with"| schizophrenia
neurodegeneration["neurodegeneration"]
SAP97 -->|"implicated in"| neurodegeneration
CASK["CASK"]
CASK -->|"binds"| SAP97
CaMKII["CaMKII"]
CaMKII -->|"phosphorylates"| SAP97
CaMKII -->|"regulates"| SAP97
PSD_95["PSD-95"]
PSD_95 -->|"interacts with"| SAP97
style SAP97 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| NR2A | binds | protein | 0.80 |
| GluA1 | interacts_with | protein | 0.80 |
| neuropathic pain | contributes_to | disease | 0.80 |
| schizophrenia | associated_with | disease | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||