protein

SNARE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SNARE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

247Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

The synaptic SNARE complex mediating neurotransmitter release - a critical hub in synaptic transmission with roles in neurodegenerative diseases

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🔬 Protein Info

Gene Symbol	SNARE
Aliases	The synaptic SNARE complex mediating neurotransmitter release
Molecular Weight	70 kDa
Amino Acids	70 aa
Pathways	autophagy pathway, insulin signaling, oxidative stress response, calcium signaling, Chaperone
GeneCards	SNARE
Human Protein Atlas	SNARE
Component	Function
Synaptophysin	Major synaptic vesicle protein, involved in vesicle formation and fusion
Synapsin I/II	Phosphoprotein that regulates vesicle mobilization and clustering
Synaptotagmin I	Calcium sensor for fast synchronous release
SNAP-25, Syntaxin	SNARE proteins mediating vesicle fusion
VAMP2 (Synaptobrevin)	Vesicular SNARE protein
Munc18	Syntaxin binding protein, essential for vesicle priming
Rab3A	GTPase regulating vesicle trafficking and release probability
Associated Diseases	ALS, Alzheimer, Neurodegenerative Diseases, Parkinson, disease, neurodegeneration
Known Drugs/Compounds	rapamycin
Interactions	STX17, VAMP7, VAMP2, SQSTM1, TFEB, TP53
KG Connections	247 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Synaptic Boutons

cell · 1853 words

→

cbs-psp-daily-action-plan

therapeutic · 30834 words

→

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Pathway Diagram

graph TD
    SNARE["<b>SNARE</b>"]
    STX17["STX17"]
    SNARE -->|"activates"| STX17
    UBIQUITIN["UBIQUITIN"]
    SNARE -->|"co discussed"| UBIQUITIN
    VAMP8["VAMP8"]
    SNARE -->|"activates"| VAMP8
    SDC1["SDC1"]
    SNARE -->|"interacts with"| SDC1
    OPTINEURIN["OPTINEURIN"]
    SNARE -->|"activates"| OPTINEURIN
    RUBICON["RUBICON"]
    SNARE -->|"activates"| RUBICON
    HSP70["HSP70"]
    SNARE -->|"activates"| HSP70
    UBIQUITIN["UBIQUITIN"]
    SNARE -->|"activates"| UBIQUITIN
    TUMOR_PROTEIN_P53["TUMOR PROTEIN P53"]
    SNARE -->|"activates"| TUMOR_PROTEIN_P53
    HSC70["HSC70"]
    SNARE -->|"activates"| HSC70
    PKM2["PKM2"]
    SNARE -->|"activates"| PKM2
    VPS34["VPS34"]
    SNARE -->|"activates"| VPS34
    KAT2B["KAT2B"]
    SNARE -->|"activates"| KAT2B
    TUMOR["TUMOR"]
    SNARE -->|"activates"| TUMOR
    PARKINSON["PARKINSON"]
    SNARE -->|"activates"| PARKINSON
    apoptosis["apoptosis"]
    SNARE -->|"activates"| apoptosis
    AMPK["AMPK"]
    SNARE -->|"activates"| AMPK
    MAP1LC3["MAP1LC3"]
    SNARE -->|"activates"| MAP1LC3
    CELL_CYCLE["CELL CYCLE"]
    SNARE -->|"activates"| CELL_CYCLE
    ACETYL_COA["ACETYL-COA"]
    SNARE -->|"activates"| ACETYL_COA
    ACAT1["ACAT1"]
    SNARE -->|"activates"| ACAT1
    Chaperone["Chaperone"]
    SNARE -->|"activates"| Chaperone
    disease["disease"]
    SNARE -->|"activates"| disease
    Proteins["Proteins"]
    SNARE -->|"activates"| Proteins
    GSK3["GSK3"]
    SNARE -->|"activates"| GSK3
    RAPAMYCIN["RAPAMYCIN"]
    SNARE -->|"activates"| RAPAMYCIN
    CHAPERONE_MEDIATED_AUTOPHAGY["CHAPERONE-MEDIATED AUTOPHAGY"]
    SNARE -->|"activates"| CHAPERONE_MEDIATED_AUTOPHAGY
    LYSOSOME["LYSOSOME"]
    SNARE -->|"associated with"| LYSOSOME
    Proteins["Proteins"]
    SNARE -->|"associated with"| Proteins
    AUTOPHAGOSOME["AUTOPHAGOSOME"]
    SNARE -->|"associated with"| AUTOPHAGOSOME

Outgoing (117)

Target	Relation	Type	Str
ALS	associated_with	disease	0.60
neurodegeneration	associated_with	disease	0.60
Parkinson	associated_with	disease	0.60
Alzheimer	associated_with	disease	0.60
SQSTM1	activates	gene	0.60
TFEB	activates	gene	0.60
TP53	activates	gene	0.60
ULK1	activates	gene	0.60
WIPI2	activates	gene	0.60
Parkinson's disease	activates	disease	0.60
Wnt signaling	participates_in	pathway	0.60
apoptosis pathway	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
SREBF1	activates	gene	0.60
SREBF2	activates	gene	0.60
STING1	activates	gene	0.60
TGM2	interacts_with	gene	0.60
VAMP8	interacts_with	gene	0.60
VAMP7	activates	gene	0.60
STX17	inhibits	gene	0.60
VAMP8	inhibits	gene	0.60
TRPML1	activates	gene	0.60
Parkinson's disease	regulates	disease	0.60
epigenetic regulation	participates_in	pathway	0.60
complement cascade	participates_in	pathway	0.60
endothelial cells	expressed_in	cell_type	0.60
schizophrenia	associated_with	disease	0.60
neurodegeneration	inhibits	disease	0.60
STX3	regulates	gene	0.60
VTI1B	regulates	gene	0.60
VAMP2	activates	gene	0.60
STX4	activates	gene	0.60
STXBP1	regulates	gene	0.60
STX17	regulates	gene	0.55
autophagy pathway	participates_in	pathway	0.55
VAMP8	regulates	gene	0.55
STX17	protects_against	gene	0.55
STX17	interacts_with	gene	0.55
STX1A	regulates	gene	0.55
STX4	regulates	gene	0.55
neurodegeneration	protects_against	disease	0.55
Parkinson's disease	interacts_with	disease	0.55
insulin signaling	participates_in	pathway	0.55
VAMP7	interacts_with	gene	0.55
oxidative stress response	participates_in	pathway	0.55
neurodegeneration	regulates	disease	0.55
neurons	expressed_in	cell_type	0.55
VAMP2	interacts_with	gene	0.55
Alzheimer's disease	targets	disease	0.55
calcium signaling	participates_in	pathway	0.55

Incoming (130)

Source	Relation	Type	Str
ACAT1	activates	gene	0.60
AMPK	activates	gene	0.60
ATG	activates	gene	0.60
CBP	activates	gene	0.60
GSK3	activates	gene	0.60
HSC70	activates	gene	0.60
KAT2B	activates	gene	0.60
LC3	activates	gene	0.60
MAP1LC3	activates	gene	0.60
MTOR	activates	gene	0.60
PKM2	activates	gene	0.60
RB1	activates	gene	0.60
RUBCNL	activates	gene	0.60
rapamycin	targets	drug	0.60
ACOX1	activates	gene	0.60
ADIPOQ	activates	gene	0.60
C1Q	activates	gene	0.60
GLP1R	activates	gene	0.60
MTORC1	activates	gene	0.60
NFE2L2	activates	gene	0.60
PRKAA2	activates	gene	0.60
RAS	activates	gene	0.60
LC3	interacts_with	gene	0.60
SDC1	interacts_with	gene	0.60
DNM1L	activates	gene	0.60
GABARAP	activates	gene	0.60
RAB7A	activates	gene	0.60
LAMP1	activates	gene	0.60
NSF	activates	gene	0.60
PS1	interacts_with	gene	0.60
LRRK2	regulates	gene	0.60
RNA	activates	gene	0.60
PARK7	inhibits	gene	0.60
PARK7	regulates	gene	0.60
SEC22B	regulates	gene	0.60
PARK7	activates	gene	0.60
SNAP25	inhibits	gene	0.60
SNAP23	activates	gene	0.60
ATG	interacts_with	gene	0.55
RAB7A	interacts_with	gene	0.55
SNAP25	regulates	gene	0.55
NSF	interacts_with	gene	0.55
CASK	interacts_with	gene	0.55
SNAP-25	interacts_with	gene	0.55
ATG14	co_discussed	gene	0.50
AUTOPHAGY	activates	gene	0.50
LYSOSOME	co_discussed	gene	0.50
SNAP29	activates	gene	0.50
TGM2	interacts_with	gene	0.50
EPG5	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SNARE

Understanding Entity Pages

Summary

Wiki Pages (21)

Synaptic Boutons

cbs-psp-daily-action-plan

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Autophagy Mechanisms

Vesicle Trafficking Dysfunction in Corticobasal Syndrome

Wnt Non-Canonical Signaling Pathways in Neurodegeneration

Mitophagy Pathway in Neurodegeneration

Synaptic Vesicle Trafficking in Parkinson's Disease

GBA Pathway in Parkinson's Disease

LRRK2 Kinase Activation and Endolysosomal Dysfunction in Parkinson's Disease

Copper Dyshomeostasis in Neurodegeneration

LRRK2 Pathway in Parkinson's Disease

ZDHHC13 — Zinc Finger DHHC-Type Containing 13

Synuclein Pathway in Parkinson's Disease

Autophagy-Lysosomal Impairment Across Neurodegenerative Diseases

Synaptic Dysfunction in Neurodegeneration

rapamycin-tauopathy

FGF10 — Fibroblast Growth Factor 10

CALM4 — Calmodulin 4