Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CIR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| trifluoperazine | treats | drug | 0.56 |
| MCU | implicated_in | gene | 0.50 |
| IBA1 | implicated_in | gene | 0.50 |
| HSPA1A | implicated_in | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Plasma ATN biomarkers across AD continuum in Chilean cohort | clinical | Alzheimer's disease | 0.950 | 0.00 | Chilean older adults (n=318) w | proposed | N/A |
| Circadian gene expression effects of SD vs ketamine | exploratory | depression | 0.950 | 0.00 | C57BL/6J mice | proposed | N/A |
| CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs AD with Co | clinical | Alzheimer's Disease | 0.900 | 0.50 | aortic endothelial cells | proposed | $6,550,000 |
| Spp1 knockout prevents synaptic loss in AD mouse models | validation | Alzheimer's disease | 0.900 | 0.00 | Spp1 knockout AD mouse models | proposed | N/A |
| Tau depletion effects on neuronal development in primary cultures | exploratory | 0.900 | 0.00 | primary rodent neuronal cultur | proposed | N/A | |
| Differential GWAS of schizophrenia vs PTSD | exploratory | schizophrenia, post-traumatic | 0.900 | 0.00 | human patients - European ance | proposed | N/A |
| Tau depletion effects on neuronal development in primary cultures | exploratory | 0.900 | 0.00 | primary rodent neuronal cultur | proposed | N/A | |
| Creation and validation of 3xAD-ChAT-Cre mouse model | validation | Alzheimer's disease | 0.900 | 0.00 | 3xAD-ChAT-Cre transgenic mice | proposed | N/A |
| CLOCK/BMAL1 regulation of ICC autophagy in GERD model | exploratory | gastroesophageal reflux diseas | 0.900 | 0.00 | primary esophageal interstitia | proposed | N/A |
| Synaptic plasticity and protein expression analysis in mPFC | exploratory | insomnia-anxiety comorbidity | 0.850 | 0.00 | mPFC brain slices from PCPA-tr | proposed | N/A |
| CHI3L1 variant association with AD progression in human patients | exploratory | Alzheimer's disease | 0.850 | 0.00 | human patients | proposed | N/A |
| GTEx brain tissue expression analysis of MAPT/CRHR1 locus | exploratory | schizophrenia, post-traumatic | 0.850 | 0.00 | human brain tissue samples fro | proposed | N/A |
| Microtubule domain analysis in adult axons | exploratory | 0.800 | 0.00 | adult rodent axons | proposed | N/A | |
| Tau depletion effects on microtubule domains in adult axons | exploratory | 0.800 | 0.00 | adult rodent neurons | proposed | N/A | |
| Brain Connectivity-Targeted tACS Trial in Early AD | clinical | Alzheimer's Disease | 0.509 | 0.50 | human postmortem brain tissue | proposed | $520,000 |
| s:** - Test tau spreading in AQP4 knockout vs wild-type mice with PSP/ | falsification | Neurodegeneration | 0.400 | 0.50 | mouse | proposed | $260,000 |
| Circadian-Vascular-Metabolic Syndrome (CVMS) Intervention Trial | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $3,900,000 |
| DLB Cognitive Fluctuation Mechanism Experiment | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Glymphatic-Circadian Axis Enhancement Therapy for Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Non-Motor Symptom Progression in Parkinson's Disease — Mechanisms and | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Integrated multimodal cell atlas of Alzheimer’s disease [PMID:39402379] | Gabitto MI, Travaglini KJ, Rachleff VM, | Nature Neuroscience | 2024 | 225 |
| From geroscience to precision geromedicine: Understanding and managing aging. [PMID:40250404] | Kroemer G, Maier AB, Cuervo AM, Gladyshe | Cell | 2025 | 1 |
| Combined effects of HCRTR1/2 gene variants and non-genetic factors on sleep-wake [PMID:40439868] | Zheng Z, Xue F, Wang H, Gu Q, Hu R, Li X | Pharmacol Rep | 2025 | 1 |
| BMAL1 involved in autophagy and injury of thoracic aortic endothelial cells of r [PMID:37086572] | Chunli Yang, Ziwei Deng, Qihang Zeng, Xi | Biochemical and biophysical re | 2023 | 1 |
| Genetic determinants of daytime napping and effects on cardiometabolic health. [PMID:33568662] | Dashti HS, Daghlas I, Lane JM, Huang Y, | Nat Commun | 2021 | 1 |
| Improved T-cell Receptor Diversity Estimates Associate with Survival and Respons [PMID:33177107] | Bortone DS, Woodcock MG, Parker JS, Vinc | Cancer Immunol Res | 2021 | 1 |
| Hypocretin/Orexin Receptor Pharmacology and Sleep Phases. [PMID:34052813] | Sun Y, Tisdale RK, Kilduff TS | Front Neurol Neurosci | 2021 | 1 |
| Spatiotemporal profile of postsynaptic interactomes integrates components of com [PMID:28671696] | Li J, Zhang W, Yang H, Howrigan DP, Wilk | Nat Neurosci | 2017 | 1 |
| Core Concept: The Internet of Things and the explosion of interconnectivity. [PMID:27702874] | Ornes S | Proc Natl Acad Sci U S A | 2016 | 1 |
| Sleep drives metabolite clearance from the adult brain. [PMID:24136970] | Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Th | Science | 2013 | 1 |
| Antidepressant effects of combined eucommia-gastrodia extract via modulation of [PMID:41921863] | Xue L, Pan Z, Liu Y, Gan Q, Liu D, Liu D | Brain research bulletin | 2026 | 0 |
| Precision Neurodegeneration: Integrating Molecular Mechanisms, Biomarkers, and T [PMID:41833042] | ["Lyu G", "Li D"] | CNS & neurological disorders d | 2026 | 0 |
| Complementary mechanisms of high-carbohydrate diets and ketogenic diets restore [PMID:41475465] | Kwon H, Seo DS, Ahmad Y, Park S, Yoo J, | The Journal of nutritional bio | 2026 | 0 |
| Epigenetics and the gut-brain axis: Insights into DNA methylation, aging, and Al [PMID:41886887] | Kumar V, Shukla R, Gangani S, Joseph R, | The Journal of pharmacology an | 2026 | 0 |
| Effects of circadian rhythms on antimicrobial peptide concentrations in lactatin [PMID:41923233] | Liang ZL, Nii T, Sugino T, Isobe N | BMC veterinary research | 2026 | 0 |
| Circadian synchronization between diet and gut microbiota in modulating host's h [PMID:41914045] | ["Ma J", "Zhen Y", "Weng Y", "Lin J", "Z | Gut microbes | 2026 | 0 |
| TrkB promotes the neuronal secretion of soluble Siglec-2 (CD22) to mitigate micr [PMID:41922794] | Shi X, Cai SZ, Chai JL, Xu CY, Zhou BY, | Molecular psychiatry | 2026 | 0 |
| Randomized controlled trial of resistance exercise and brain aging clocks. [PMID:41665740] | ["Gonzalez-Gomez R", "Demnitz N", "Coron | GeroScience | 2026 | 0 |
| The Potential Functions and Beneficial Effects of Melatonin on Cognitive Impairm [PMID:41917799] | Li XY, Cheng YZ, Zhang YM, Hu F, Fang SK | Brain and behavior | 2026 | 0 |
| Biomarkers for Alzheimer's disease across diverse biological domains: an umbrell [PMID:40680830] | Kang J, Son Y, Yim Y, Cho H, Kim J et al | J Adv Res | 2026 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CIR in their description or question text
Score: 0.763 · neurodegeneration · 2026-04-02
## Mechanistic Overview Circadian Clock-Autophagy Synchronization starts from the claim that modulating CLOCK within the
Score: 0.760 · neuroscience · 2026-04-07
## **Molecular Mechanism and Rationale** The cholinergic basal forebrain-hippocampal circuit protection hypothesis cent
Score: 0.751 · neuroscience · 2026-04-07
## Mechanistic Overview Dopaminergic Ventral Tegmental-Hippocampal Circuit Protection starts from the claim that modulat
Score: 0.745 · unknown disease · 2026-04-26
Soluble PDGFRβ (sPDGFRβ) is released into the bloodstream upon pericyte damage, serving as a peripheral indicator of blo
Score: 0.744 · neurodegeneration · 2026-04-02
# Detailed Scientific Description: Circadian-Synchronized Proteostasis Enhancement ## Molecular Mechanism and Rationale
Score: 0.744 · neurodegeneration · 2026-04-12
**Molecular Mechanism and Rationale** The TREM2-SIRT1 metabolic senescence circuit represents a critical regulatory net
Score: 0.722 · neurodegeneration · 2026-04-02
## Mechanistic Overview Circadian Rhythm Entrainment of Reactive Astrocytes starts from the claim that modulating BMAL1
Score: 0.718 · neurodegeneration · 2026-04-02
## Mechanistic Overview Retinal Vascular Microcirculation Rescue starts from the claim that modulating PDGFRB/ANGPT1 wit
Score: 0.714 · neurodegeneration · 2026-04-02
## Mechanistic Overview Circadian-Synchronized LRP1 Pathway Activation starts from the claim that modulating LRP1, MTNR1
Score: 0.712 · neurodegeneration · 2026-04-02
## Mechanistic Overview Circadian Glymphatic Rescue Therapy (Melatonin-focused) starts from the claim that modulating MT
Score: 0.709 · neurodegeneration · 2026-04-02
## Mechanistic Overview Metabolic Circuit Breaker via Lipid Droplet Modulation starts from the claim that modulating PLI
Score: 0.700 · neurodegeneration · 2026-04-02
## Mechanistic Overview Nutrient-Sensing Epigenetic Circuit Reactivation starts from the claim that modulating SIRT1 wit
Score: 0.691 · neurodegeneration · 2026-04-04
## Molecular Mechanism and Rationale The cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING) path
Score: 0.683 · neurodevelopment · 2026-04-15
## Mechanistic Overview Interneuron SYNGAP1 Deficiency Disrupts Cortical Circuit Assembly During Development starts from
Score: 0.670 · alzheimers · 2026-04-28
Delivering 40 Hz (gamma) tFUS or sensory entrainment adaptively synchronized to real-time theta phase detection to resto