Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CIR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| trifluoperazine | treats | drug | 0.56 |
| MCU | implicated_in | gene | 0.50 |
| IBA1 | implicated_in | gene | 0.50 |
| HSPA1A | implicated_in | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.497
neurodegeneration | 2026-04-14 | 2 hypotheses Top: 0.589
synaptic biology | 2026-04-14 | 1 hypotheses Top: 0.526
neurodegeneration | 2026-04-12 | 0 hypotheses
neurodegeneration | 2026-04-11 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| From geroscience to precision geromedicine: Understanding and managing aging. [PMID:40250404] | Kroemer G, Maier AB, Cuervo AM, Gladyshe | Cell | 2025 | 1 |
| Combined effects of HCRTR1/2 gene variants and non-genetic factors on sleep-wake [PMID:40439868] | Zheng Z, Xue F, Wang H, Gu Q, Hu R, Li X | Pharmacol Rep | 2025 | 1 |
| BMAL1 involved in autophagy and injury of thoracic aortic endothelial cells of r [PMID:37086572] | Chunli Yang, Ziwei Deng, Qihang Zeng, Xi | Biochemical and biophysical re | 2023 | 1 |
| Genetic determinants of daytime napping and effects on cardiometabolic health. [PMID:33568662] | Dashti HS, Daghlas I, Lane JM, Huang Y, | Nat Commun | 2021 | 1 |
| Hypocretin/Orexin Receptor Pharmacology and Sleep Phases. [PMID:34052813] | Sun Y, Tisdale RK, Kilduff TS | Front Neurol Neurosci | 2021 | 1 |
| Improved T-cell Receptor Diversity Estimates Associate with Survival and Respons [PMID:33177107] | Bortone DS, Woodcock MG, Parker JS, Vinc | Cancer Immunol Res | 2021 | 1 |
| Prevalence of symptoms of depression, anxiety, insomnia, posttraumatic stress di [PMID:33285346] | Cénat JM, Blais-Rochette C, Kokou-Kpolou | Psychiatry Res | 2021 | 1 |
| Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Seque [PMID:32822576] | Maynard A, McCoach CE, Rotow JK, Harris | Cell | 2020 | 1 |
| The Ca(2+) Sensor SCaBP3/CBL7 Modulates Plasma Membrane H(+)-ATPase Activity and [PMID:30962395] | Yang Y, Wu Y, Ma L, Yang Z, Dong Q, Li Q | Plant Cell | 2019 | 1 |
| Spatiotemporal profile of postsynaptic interactomes integrates components of com [PMID:28671696] | Li J, Zhang W, Yang H, Howrigan DP, Wilk | Nat Neurosci | 2017 | 1 |
| Core Concept: The Internet of Things and the explosion of interconnectivity. [PMID:27702874] | Ornes S | Proc Natl Acad Sci U S A | 2016 | 1 |
| Sleep drives metabolite clearance from the adult brain. [PMID:24136970] | Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Th | Science | 2013 | 1 |
| Impact of preinterventional plaque composition and eccentricity on late-acquired [PMID:22936019] | Sato T, Kameyama T, Noto T, Nozawa T, In | Coron Artery Dis | 2012 | 1 |
| Fasting as Medicine: Mitochondrial and Endothelial Rejuvenation in Vascular Agin [PMID:41521387] | ["Milan M", "Troyano-Rodriguez E", "Ihuo | Aging cell | 2026 | 0 |
| NAD+ subcellular partitioning mediated by miR-183 and miR-96 regulates muscle st [PMID:41915008] | Ma M, Ma R, Li Z, Shen S, Kong W, Qiu T, | Journal of molecular cell biol | 2026 | 0 |
| Rhodiola sacra Protects Against Hippocampal Neuronal Apoptosis in Chronic Cerebr [PMID:41879438] | Zhou L, Jia J, Li J, Yao Z, Fu Z, Wang S | Current neuropharmacology | 2026 | 0 |
| Mechanistic Modulation of Autophagy by Bioactive Natural Products: Implications [PMID:41830033] | Jalouli M, Harrath AH, Al-Zharani M, Rah | Nutrients | 2026 | 0 |
| Mechanistic advances in exercise‑mediated regulation of autophagy dysfunction in [PMID:41645754] | Li W, Wang WH, Song Y, Li XJ, Li Y et al | Int J Mol Med | 2026 | 0 |
| Unravelling the therapeutic potential of chrysin against ischemic stroke and pos [PMID:41687709] | Achar PG, Krishna KL, C P K, Patil M, Pr | Neuroscience | 2026 | 0 |
| Loss of REST associated with Alzheimer's disease pathology is ameliorated by NAD [PMID:41709697] | Lagartos-Donate MJ, Escobar-Doncel B, Zh | Brain | 2026 | 0 |