concept

COMPLEMENT C3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about COMPLEMENT C3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

27Connections

2Hypotheses

2Analyses

18Outgoing

9Incoming

0Experiments

2Debates

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💡 Concept Info

Name	COMPLEMENT C3
Key Genes/Proteins	C3A FRAGMENT

Pathway Diagram

graph TD
    COMPLEMENT_C3["COMPLEMENT C3"]
    COMPLEMENT_C3 -->|"product_of"| C3A_FRAGMENT["C3A FRAGMENT"]
    COMPLEMENT_C3 -->|"contributes to"| Demyelination["Demyelination"]
    COMPLEMENT_C3 -->|"causes"| Astrocyte_Injury["Astrocyte Injury"]
    COMPLEMENT_C3 -->|"activates"| Microglial_Activation["Microglial Activation"]
    COMPLEMENT_C3 -->|"involved_in"| Astrocyte_Microglia_Crosstalk["Astrocyte-Microglia Crosstalk"]
    COMPLEMENT_C3 -->|"interacts"| C3aR["C3aR"]
    COMPLEMENT_C3 -->|"binds"| CR3["CR3"]
    COMPLEMENT_C3 -->|"exacerbates"| __Synuclein["alpha-Synuclein"]
    CR2_Crry["CR2-Crry"] -->|"inhibits"| COMPLEMENT_C3
    Astrocytes["Astrocytes"] -->|"product_of"| COMPLEMENT_C3
    Complement_C1q["Complement C1q"] -->|"activates"| COMPLEMENT_C3
    TLR2["TLR2"] -->|"regulates"| COMPLEMENT_C3
    NF__B["NF-kappaB"] -->|"regulates"| COMPLEMENT_C3

Outgoing (18)

Target	Relation	Type	Str
C3A FRAGMENT	product_of	protein	0.90
Motor Dysfunction	promotes	phenotype	0.90
PARKINSON'S DISEASE	involved_in	disease	0.90
Astrocyte Injury	causes	process	0.90
Dopaminergic Neuron Loss	promotes	phenotype	0.90
Demyelination	contributes_to	process	0.90
Microglial Activation	activates	process	0.85
Astrocyte-Microglia Crosstalk	involved_in	process	0.85
ASTROCYTES	expressed_in	cell_type	0.85
neuromyelitis optica	mediates	disease	0.80
α-Synuclein	exacerbates	protein	0.80
CR3	binds	receptor	0.80
C3aR	interacts_with	receptor	0.80
ASTROCYTE	activates	cell_type	0.80
ASTROCYTES	activates	cell_type	0.80
synaptic loss	causes	phenotype	0.70
neurodegeneration	causes	disease	0.70
Parkinson's Disease	associated_with	disease	0.70

Incoming (9)

Source	Relation	Type	Str
CR2-Crry	inhibits	compound	0.92
Astrocytes	product_of	cell_type	0.90
33558694	increased under	paper	0.90
33558694	potentiated in	paper	0.90
33558694	further enhanced in	paper	0.90
Complement C1q	activates	protein	0.80
Nf-Κb	upregulates	protein	0.80
33558694	increased under	paper	0.60
33558694	implicated in	paper	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Circulating hs-CRP as Disease-Modifying Target via Astrocyti	0.387	immunomics	Systemic immune profiling in neurodegene
Complement C3/C3aR Synaptic Protection Therapy	0.000	-	Immune atlas neuroinflammation analysis