Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Complement C1q: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| CR3 Receptor | interacts_with | receptor | 0.90 |
| synapse loss | causes | phenotype | 0.90 |
| Complement C3 | activates | protein | 0.80 |
| synaptic loss | causes | phenotype | 0.70 |
| synapse deposition | causes | phenotype | 0.70 |
| synaptic pruning | causes | process | 0.70 |
| synaptic pruning | activates | process | 0.70 |
| dendritic spine pruning | activates | phenotype | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TREM2 | binds_to | gene | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Complement C1q-Mediated Synaptic Pruning Drives Early Cognit | 0.769 | neurodegeneration | Legacy Pre-Pipeline Hypothesis Import |
| Complement C1q Mimetic Decoy Therapy | 0.695 | neurodegeneration | Synaptic pruning by microglia in early A |
| Complement C1q/C3 Inhibition to Prevent Synaptodendritis in | 0.690 | neurodegeneration | Test |
| Complement C1QA Spatial Gradient in Cortical Layers | 0.678 | alzheimers | SEA-AD Gene Expression Profiling — Allen |
| Complement C1q Subtype Switching | 0.665 | neurodegeneration | 4R-tau strain-specific spreading pattern |
| Complement C1QA Inhibition Synergizes with PV Interneuron Mo | 0.659 | neurodegeneration | What molecular mechanisms underlie the d |
| Complement C1q/C3 Blockade for Alzheimer's Disease | 0.619 | neurodegeneration | Test |
| Complement C1q Suppression as Mechanism Linking Exercise Pla | 0.560 | neurodegeneration | What are the specific circulating factor |
| Complement C1q Blockade for Selective Pruning Prevention | 0.000 | - | Synaptic pruning by microglia in early A |
Scientific analyses that reference this entity
neuroinflammation | 2026-04-16 | 5 hypotheses Top: 0.597
neurodegeneration | 2026-04-16 | 0 hypotheses
neuroinflammation | 2026-04-14 | 2 hypotheses Top: 0.586
neurodegeneration | 2026-04-14 | 0 hypotheses
neuroinflammation | 2026-04-08 | 5 hypotheses Top: 0.658
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| C1q neutralization experiment | validation | perioperative neurocognitive d | 0.900 | 0.00 | rats | proposed | N/A |
| scRNA-seq analysis of human atherosclerotic plaques | exploratory | Atherosclerosis | 0.900 | 0.00 | human atherosclerotic plaque s | proposed | N/A |
| Sevoflurane-induced neurotoxicity (SIN) model in rats | validation | perioperative neurocognitive d | 0.900 | 0.00 | rats | proposed | N/A |
| Machine learning-based identification of C1Q hub genes | exploratory | Atherosclerosis | 0.900 | 0.00 | Human bulk RNA sequencing data | proposed | N/A |
| Gene expression validation in apoE-/- mice | validation | Atherosclerosis | 0.850 | 0.00 | apoE-/- mice | proposed | N/A |
| ox-LDL treatment of RAW264.7 macrophages | exploratory | Atherosclerosis | 0.850 | 0.00 | RAW264.7 macrophages | proposed | N/A |
| Validation of hub genes in ox-LDL treated RAW264.7 macrophages | exploratory | Atherosclerosis | 0.800 | 0.00 | RAW264.7 macrophages | proposed | N/A |
| Validation of hub genes in apoE-/- atherosclerotic mice | validation | Atherosclerosis | 0.800 | 0.00 | apoE-/- mice | proposed | N/A |
| s:** - Compare brain penetration in FcRn+/+ vs FcRn-/- mice with engin | falsification | Neuroinflammation | 0.400 | 0.50 | mouse | proposed | $200,000 |
| Proposed experiment from debate on Synaptic pruning by microglia in ea | falsification | Alzheimer's Disease | 0.400 | 0.50 | mouse | proposed | $200,000 |
| Experiment: Autoimmune Hypothesis Testing in AD | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Prolonged anesthesia induces neuroinflammation and complement-mediated microglia [PMID:36600274] | Xu F, Han L, Wang Y, Deng D, Ding Y, Zha | BMC Med | 2023 | 2 |
| Perivascular cells induce microglial phagocytic states and synaptic engulfment v [PMID:36747024] | De Schepper S, Ge JZ, Sierksma A, Crowle | Nat Neurosci | 2023 | 2 |
| An integrative analysis of single-cell and bulk transcriptome and bidirectional [PMID:38179058] | Cui HK, Tang CJ, Gao Y, Li ZA, Zhang J, | Front Immunol | 2023 | 2 |
| Young adult microglial deletion of C1q reduces engulfment of synapses and preven [PMID:41000995] | Petrisko TJ, Chu SH, Gomez-Arboledas A, | bioRxiv : the preprint server | 2025 | 1 |
| The Role of Complement in Synaptic Pruning and Neurodegeneration. [PMID:34595138] | Gomez-Arboledas A, Acharya MM, Tenner AJ | ImmunoTargets and therapy | 2021 | 1 |
| Early complement genes are associated with visual system degeneration in multipl [PMID:31289819] | Fitzgerald KC, Kim K, Smith MD, Aston SA | Brain | 2019 | 1 |
| Pioglitazone attenuates complement-mediated microglial synaptic engulfment in an [PMID:41396874] | Unknown | Brain : a journal of neurology | 2026 | 0 |
| Molecular Insights Into Canine Hepatocellular Carcinoma: A Cross-Species Transcr [PMID:41664952] | Arif M, Hasan MN, Nozaki N, Ide Y, Akiya | Mol Carcinog | 2026 | 0 |
| Phosphoproteomics uncovers a neuroimmune perspective on trigeminal neuralgia: se [PMID:41853292] | Zhai X, Lin X, Zhang L, Ren Y, Miao H, M | Frontiers in immunology | 2026 | 0 |
| Proteomic Signature in Men with Central Serous Chorioretinopathy. [PMID:41641862] | Chambon C, Picard E, Zola M, Aichedo S, | Journal of proteome research | 2026 | 0 |
| Machine Learning and Blood-Targeted Proteomics Enable Early Prediction and Etiol [PMID:41683823] | Starodubtseva N, Tokareva A, Kononikhin | International journal of molec | 2026 | 0 |
| Club cell RhoA activation amplifies allergic airway inflammation by regulating e [PMID:41633491] | Tu W, Wu M, Wan R, Alphonse M, Gu W, Gho | The Journal of allergy and cli | 2026 | 0 |
| Identifying the hub genes in macrophage infiltration and verifying of the role o [PMID:41730938] | Tang L, Xu Y, Nong Z, Li F, Pan L | Scientific reports | 2026 | 0 |
| Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746] | ["Sanadgol N", "Abedi M", "Hashemzaei M" | Journal of nanobiotechnology | 2025 | 0 |
| C5aR1 signaling promotes region- and age-dependent synaptic pruning in models of [PMID:38278523] | ["Angela Gomez-Arboledas", "Maria I Fons | Alzheimer's & dementia : t | 2024 | 0 |
| The dopamine analogue CA140 alleviates AD pathology, neuroinflammation, and resc [PMID:39129007] | Chae S, Lee HJ, Lee HE, Kim J, Jeong YJ, | Journal of neuroinflammation | 2024 | 0 |
| Identification of crosstalk genes and immune characteristics between Alzheimer's [PMID:39188714] | An W, Zhou J, Qiu Z, Wang P, Han X, Chen | Frontiers in immunology | 2024 | 0 |
| Single-cell RNA sequencing reveals distinct immunology profiles in human keloid. [PMID:35990663] | ["Feng C", "Shan M", "Xia Y", "Zheng Z", | Frontiers in immunology | 2022 | 0 |
| [WALANT - Wide Awake Local Anaesthesia No Tourniquet: Complications in elective [PMID:35168268] | Wieschollek S, Forster S, Megerle K | Handchirurgie, Mikrochirurgie, | 2022 | 0 |
| Evaluation method for cell-free in situ tissue-engineered vasculature monitoring [PMID:35436313] | ["Matsumura G", "Isayama N", "Sato H"] | PloS one | 2022 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.74 · 2026-04-21
closed · Rounds: 4 · Score: 0.50 · 2026-04-18
closed · Rounds: 4 · Score: 0.94 · 2026-04-16
closed · Rounds: 4 · Score: 0.60 · 2026-04-16
closed · Rounds: 4 · Score: 0.56 · 2026-04-15
closed · Rounds: 4 · Score: 0.76 · 2026-04-12
closed · Rounds: 4 · Score: 0.78 · 2026-04-12
closed · Rounds: 4 · Score: 0.50 · 2026-04-11
Hypotheses and analyses mentioning Complement C1q in their description or question text
Score: 0.659 · neurodegeneration · 2026-04-13
## Mechanistic Overview Complement C1QA Inhibition Synergizes with PV Interneuron Modulation starts from the claim that
Score: 0.619 · neurodegeneration · 2026-05-06
Microglia-mediated complement activation (C1q, C3) leads to excessive synaptic pruning in AD. Tau pathology sensitizes n
Score: 0.560 · neurodegeneration · 2026-04-14
## Mechanistic Overview Complement C1q Suppression as Mechanism Linking Exercise Plasma to PV Interneuron Protection sta
Score: 0.000 · unknown disease · 2026-04-28
A selective C1q inhibitor that only blocks pathological complement tagging while preserving physiological pruning could