Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CR3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| microglial phagocytosis of synapses | mediates | process | 1.00 |
| Synapse Loss | involved_in | phenotype | 0.90 |
| Synaptic Material Engulfment | involved_in | process | 0.90 |
| Synaptic Engulfment | mediates | process | 0.90 |
| Alzheimer's Disease | risk_factor_for | disease | 0.90 |
| Synaptic Pruning | involved_in | process | 0.85 |
| Phagocytic Microglia | regulates | phenotype | 0.85 |
| Synaptic Pruning | mediates | process | 0.85 |
| Microglia | expressed_in | cell_type | 0.85 |
| Microglial Phagocytosis | mediates | biological_process | 0.80 |
| complement cascade | participates_in | pathway | 0.80 |
| neurons | expressed_in | cell_type | 0.80 |
| synaptic remodeling | promotes | process | 0.70 |
| TREM2 | implicated_in | gene | 0.60 |
| TYROBP | implicated_in | gene | 0.60 |
| TREM2 | interacts_with | gene | 0.60 |
| DAP12 | activates | gene | 0.60 |
| TREM2 | activates | gene | 0.60 |
| TYROBP | activates | gene | 0.60 |
| CX3CR1 | activates | gene | 0.60 |
| neuroinflammation | activates | disease | 0.60 |
| neurodegeneration | activates | disease | 0.60 |
| neuroinflammation | associated_with | disease | 0.60 |
| ferroptosis | participates_in | pathway | 0.60 |
| neurodegeneration | associated_with | disease | 0.60 |
| NOX2 | activates | gene | 0.60 |
| NOX2 | regulates | gene | 0.60 |
| Alzheimer's disease | implicated_in | disease | 0.60 |
| Alzheimer's disease | interacts_with | disease | 0.60 |
| synaptic plasticity | participates_in | pathway | 0.60 |
| RNA | implicated_in | gene | 0.60 |
| Parkinson's disease | activates | disease | 0.60 |
| ROS | activates | gene | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| Parkinson's disease | regulates | disease | 0.60 |
| microglia | expressed_in | cell_type | 0.55 |
| macrophages | expressed_in | cell_type | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| C1Q | signals_through | protein | 1.00 |
| C3 | signals_through | protein | 1.00 |
| TYROBP | binds | protein | 0.95 |
| C3 | binds | protein | 0.85 |
| Complement C3 | binds | protein | 0.80 |
| C1Q | interacts_with | protein | 0.80 |
| C3 | interacts_with | protein | 0.72 |
| C3 | activates | gene | 0.70 |
| C3 | associated_with | gene | 0.70 |
| TYROBP | interacts_with | protein | 0.64 |
| C3 | inhibits | gene | 0.60 |
| CD33 | implicated_in | gene | 0.60 |
| CD33 | interacts_with | gene | 0.60 |
| CD33 | activates | gene | 0.60 |
| CD47 | activates | gene | 0.60 |
| C3 | regulates | gene | 0.60 |
| C3 | implicated_in | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neuroinflammation | 2026-04-14 | 2 hypotheses Top: 0.567
neurodegeneration | 2026-04-04 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||