Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CR3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | CR3 |
| Key Genes/Proteins | C1Q, C3, CD33, CD47, Complement C3, CX3CR1 |
| Related Diseases | Alzheimer's disease, Alzheimer's Disease |
| Related Pathways | complement cascade, ferroptosis |
| Linked Hypotheses | 2 hypotheses |
Knowledge base pages for this entity
graph TD
CR3[CR3]
CR3 -->|mediates| microglial_phagocytosis_of_syn[microglial phagocytosis of synapses]
CR3 -->|involved_in| Synapse_Loss[Synapse Loss]
CR3 -->|involved_in| Synaptic_Material_Engulfment[Synaptic Material Engulfment]
CR3 -->|mediates| Synaptic_Engulfment[Synaptic Engulfment]
CR3 -->|risk_factor_for| Alzheimer_s_Disease[Alzheimer's Disease]
CR3 -->|involved_in| Synaptic_Pruning[Synaptic Pruning]
CR3 -->|regulates| Phagocytic_Microglia[Phagocytic Microglia]
CR3 -->|expressed in| Microglia[Microglia]
CR3 -->|mediates| Microglial_Phagocytosis[Microglial Phagocytosis]
C1Q[C1Q] -->|signals_through| CR3
C3[C3] -->|signals_through| CR3
TYROBP[TYROBP] -->|binds| CR3
Complement_C3[Complement C3] -->|binds| CR3| Target | Relation | Type | Str |
|---|---|---|---|
| microglial phagocytosis of synapses | mediates | process | 1.00 |
| Alzheimer's Disease | risk_factor_for | disease | 0.90 |
| Synapse Loss | involved_in | phenotype | 0.90 |
| Synaptic Material Engulfment | involved_in | process | 0.90 |
| Synaptic Engulfment | mediates | process | 0.90 |
| Synaptic Pruning | involved_in | process | 0.85 |
| Phagocytic Microglia | regulates | phenotype | 0.85 |
| Synaptic Pruning | mediates | process | 0.85 |
| Microglia | expressed_in | cell_type | 0.85 |
| Microglial Phagocytosis | mediates | process | 0.80 |
| neurons | expressed_in | cell_type | 0.80 |
| complement cascade | participates_in | pathway | 0.80 |
| synaptic pruning | activates | process | 0.70 |
| Microglial Phagocytosis | activates | phenotype | 0.70 |
| synaptic remodeling | promotes | process | 0.70 |
| synaptic phagocytosis | mediates | mechanism | 0.70 |
| TREM2 | activates | gene | 0.60 |
| TYROBP | activates | gene | 0.60 |
| TREM2 | interacts_with | gene | 0.60 |
| DAP12 | activates | gene | 0.60 |
| Alzheimer's disease | interacts_with | disease | 0.60 |
| RNA | implicated_in | gene | 0.60 |
| Alzheimer's disease | implicated_in | disease | 0.60 |
| Parkinson's disease | activates | disease | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| Parkinson's disease | regulates | disease | 0.60 |
| ROS | activates | gene | 0.60 |
| synaptic plasticity | participates_in | pathway | 0.60 |
| CX3CR1 | activates | gene | 0.60 |
| neuroinflammation | activates | disease | 0.60 |
| neurodegeneration | activates | disease | 0.60 |
| neuroinflammation | associated_with | disease | 0.60 |
| ferroptosis | participates_in | pathway | 0.60 |
| neurodegeneration | associated_with | disease | 0.60 |
| NOX2 | activates | gene | 0.60 |
| NOX2 | regulates | gene | 0.60 |
| TYROBP | implicated_in | gene | 0.60 |
| TREM2 | implicated_in | gene | 0.60 |
| macrophages | expressed_in | cell_type | 0.55 |
| microglia | expressed_in | cell_type | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| C3 | associated_with | protein | 1.00 |
| C1Q | signals_through | protein | 1.00 |
| TYROBP | binds | protein | 0.95 |
| Complement C3 | binds | protein | 0.80 |
| C1Q | interacts_with | protein | 0.80 |
| C3 | interacts_with | protein | 0.72 |
| C3 | activates | gene | 0.70 |
| TYROBP | interacts_with | protein | 0.64 |
| C3 | inhibits | gene | 0.60 |
| CD33 | implicated_in | gene | 0.60 |
| CD47 | activates | gene | 0.60 |
| C3 | regulates | gene | 0.60 |
| CD33 | interacts_with | gene | 0.60 |
| CD33 | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Excessive C1q/C3/CR3 complement cascade activation initiates | 0.720 | neurodegeneration | Synaptic pruning by microglia in neurode |
Scientific analyses that reference this entity
neuroinflammation | 2026-04-14 | 2 hypotheses Top: 0.586
neuroinflammation | 2026-04-14 | 0 hypotheses
neurodegeneration | 2026-04-04 | 0 hypotheses
neurodegeneration | 2026-04-02 | 7 hypotheses Top: 0.720
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.68 · 2026-04-22
closed · Rounds: 4 · Score: 0.70 · 2026-04-16
closed · Rounds: 4 · Score: 0.56 · 2026-04-15
closed · Rounds: 3 · Score: 0.95 · 2026-04-04
Hypotheses and analyses mentioning CR3 in their description or question text
No additional research found