Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Motor Dysfunction: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | Motor Dysfunction |
| Key Genes/Proteins | FKBP51, Complement C3, HERV-K, EFTUD2 |
| Related Diseases | AADC Deficiency |
| Related Pathways | Usp9X Suppression, C3 Overexpression, TREM2 Deficiency, Gut-Brain Signaling, Complement C3 Inhibition |
Knowledge base pages for this entity
graph TD
Motor_Dysfunction["Motor Dysfunction"] -->|"associated"| C3_Overexpression["C3 Overexpression"]
style C3_Overexpression fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
TREM2_Deficiency["TREM2 Deficiency"] -->|"causes"| Motor_Dysfunction["Motor Dysfunction"]
style TREM2_Deficiency fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
FKBP51["FKBP51"] -->|"modulates"| Motor_Dysfunction["Motor Dysfunction"]
style FKBP51 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
Dopaminergic_Neuron_Loss["Dopaminergic Neuron Loss"] -->|"causes"| Motor_Dysfunction["Motor Dysfunction"]
style Dopaminergic_Neuron_Loss fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
AADC_Deficiency["AADC Deficiency"] -->|"causes"| Motor_Dysfunction["Motor Dysfunction"]
style AADC_Deficiency fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
TGR5["TGR5"] -->|"regulates"| Motor_Dysfunction["Motor Dysfunction"]
style TGR5 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
style Motor_Dysfunction fill:#5d4400,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold| Target | Relation | Type | Str |
|---|---|---|---|
| C3 Overexpression | associated_with | mechanism | 0.90 |
| ALS | biomarker_for | disease | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Usp9X Suppression | treats | mechanism | 0.95 |
| TREM2 Deficiency | causes | mechanism | 0.90 |
| FKBP51 | modulates | protein | 0.90 |
| Dopaminergic Neuron Loss | causes | process | 0.90 |
| AADC Deficiency | causes | disease | 0.90 |
| TGR5 | regulates | receptor | 0.90 |
| Complement C3 | promotes | protein | 0.90 |
| Rotenone | causes | compound | 0.90 |
| CR2-Crry | protects_against | compound | 0.88 |
| Gut-Brain Signaling | modulates | pathway | 0.85 |
| Complement C3 Inhibition | associated_with | mechanism | 0.85 |
| HERV-K | causes | gene | 0.85 |
| EFTUD2 | associated_with | gene | 0.85 |
| Dopaminergic Neurons | involved_in | cell_type | 0.85 |
| RIPK1 | promotes | protein | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||