Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CAFFEINE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | CAFFEINE |
Knowledge base pages for this entity
graph TD
CAFFEINE["CAFFEINE"]
CAFFEINE -->|"inhibits"| A1["A1"]
CAFFEINE -->|"inhibits"| A2A["A2A"]
CAFFEINE -->|"inhibits"| A2B["A2B"]
CAFFEINE -->|"inhibits"| A3["A3"]
CAFFEINE -->|"inhibits"| ADENOSINE_RECEPTORS["ADENOSINE RECEPTORS"]
CAFFEINE -->|"modulates"| Sleep["Sleep"]
CAFFEINE -->|"modulates"| Learning_And_Memory["Learning And Memory"]
CAFFEINE -->|"inhibits"| PDE1["PDE1"]| Target | Relation | Type | Str |
|---|---|---|---|
| A1 | inhibits | receptor | 0.95 |
| A2A | inhibits | receptor | 0.95 |
| A2B | inhibits | receptor | 0.95 |
| A3 | inhibits | receptor | 0.95 |
| ADENOSINE RECEPTORS | inhibits | receptor | 0.95 |
| ADORA1 | inhibits | receptor | 0.95 |
| ADORA2B | inhibits | receptor | 0.95 |
| ADORA3 | inhibits | receptor | 0.95 |
| Sleep | modulates | process | 0.90 |
| Learning And Memory | modulates | phenotype | 0.88 |
| PDE1 | inhibits | enzyme | 0.85 |
| PDE4 | inhibits | enzyme | 0.85 |
| PDE5 | inhibits | enzyme | 0.85 |
| Cognition | modulates | process | 0.85 |
| Learning | modulates | process | 0.85 |
| Memory | modulates | process | 0.85 |
| PHOSPHODIESTERASES | inhibits | enzyme | 0.85 |
| Calcium Release | associated_with | process | 0.80 |
| GABA-A RECEPTORS | modulates | receptor | 0.75 |
| GABA-A receptor | modulates | protein | 0.75 |
| Alzheimer's Disease | treats | disease | 0.75 |
| Parkinson's Disease | treats | disease | 0.75 |
| Alzheimer's Disease | targets | disease | 0.75 |
| Parkinson's Disease | targets | disease | 0.75 |
| Depression | targets | disease | 0.75 |
| Alzheimer'S Disease | treats | disease | 0.75 |
| Parkinson'S Disease | treats | disease | 0.75 |
| Alzheimer's Disease | modulates | disease | 0.70 |
| Parkinson's Disease | modulates | disease | 0.70 |
| Depression | treats | disease | 0.65 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||