gene

adora1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about adora1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

40Connections

0Hypotheses

1Analyses

28Outgoing

12Incoming

0Experiments

1Debates

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🧬 Gene Info

Gene Symbol	ADORA1
Full Name	Adenosine A1 Receptor
Chromosome	1q32.1
Function	encodes a 326-amino acid protein that is widely expressed throughout the central and peripheral nervous systems.
Amino Acids	326 aa
Pathways	Epigenetic, Synaptic Plasticity
GeneCards	ADORA1
Human Protein Atlas	ADORA1
Associated Diseases	slow-wave_sleep
Known Drugs/Compounds	Caffeine
Interactions	ALZHEIMER, ALZHEIMER'S DISEASE, App, ASTROCYTE, LCN2, MEF2C
KG Connections	36 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ADORA1 Gene

gene · 1272 words

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Pathway Diagram

graph TD
    ADORA1["ADORA1"]
    ADORA1 -->|"activates"| Als["Als"]
    ADORA1 -->|"activates"| Ms["Ms"]
    ADORA1 -->|"activates"| Alzheimer["Alzheimer"]
    ADORA1 -->|"expressed in"| ADORA3["ADORA3"]
    ADORA1 -->|"activates"| ALZHEIMER["ALZHEIMER"]
    ADORA1 -->|"activates"| TAU["TAU"]
    ADORA1 -->|"expressed in"| MAPT["MAPT"]
    ADORA1 -->|"activates"| MEF2C["MEF2C"]
    ASTROCYTE["ASTROCYTE"] -->|"activates"| ADORA1
    LCN2["LCN2"] -->|"activates"| ADORA1
    ALZHEIMER -->|"activates"| ADORA1
    MEF2C -->|"activates"| ADORA1
    MAPT -->|"expressed in"| ADORA1
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"] -->|"activates"| ADORA1
    TAU_PATHOLOGY["TAU PATHOLOGY"] -->|"activates"| ADORA1
    AND["AND"] -->|"expressed in"| ADORA1

Outgoing (28)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ADORA1	data_in	dataset_row	0.00
LCN2	promotes	gene	0.90
Memory Impairment	promotes	phenotype	0.85
Alzheimer'S Disease	involved_in	disease	0.85
Synaptic Plasticity	inhibits	phenotype	0.85
slow-wave_sleep	associated_with	phenotype	0.70
Als	activates	disease	0.65
Ms	activates	disease	0.65
Alzheimer	activates	disease	0.65
LCN2	activates	gene	0.60
Epigenetic	activates	pathway	0.60
Synaptic Plasticity	activates	pathway	0.60
Neuron	expressed_in	cell_type	0.60
tau pathology	associated_with	process	0.60
NEURON	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
Astrocyte	activates	cell_type	0.60
TAU	activates	gene	0.60
MAPT	expressed_in	gene	0.60
MEF2C	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
App	activates	protein	0.60
ADORA3	expressed_in	gene	0.60
Astrocyte	expressed_in	cell_type	0.55
Neuron	expressed_in	cell_type	0.50
NEURONS	expressed_in	concept	0.50
MAPT	expressed_in	gene	0.50

Incoming (12)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ADORA1	data_in	dataset_row	0.00
Caffeine	inhibits	drug	0.95
adenosine	activates	compound	0.90
MAPT	upregulates	gene	0.90
MIR133A	downregulates	gene	0.85
MAPT	expressed_in	gene	0.60
LCN2	activates	gene	0.60
MEF2C	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
TAU PATHOLOGY	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
ASTROCYTE	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Perivascular spaces and glymphatic clearance failure in AD

neurodegeneration | 2026-04-01 | 14 hypotheses Top: 0.882

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Perivascular spaces and glymphatic clearance failure in AD

closed · Rounds: 4 · Score: 0.95 · 2026-04-06

Related Research

Hypotheses and analyses mentioning adora1 in their description or question text

No additional research found