Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about adora1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ADORA1 |
| Full Name | Adenosine A1 Receptor |
| Chromosome | 1q32.1 |
| Function | encodes a 326-amino acid protein that is widely expressed throughout the central and peripheral nervous systems. |
| Amino Acids | 326 aa |
| Pathways | Epigenetic, Synaptic Plasticity |
| GeneCards | ADORA1 |
| Human Protein Atlas | ADORA1 |
| Associated Diseases | Alzheimer's disease, Epilepsy |
| KG Connections | 3 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
ADORA1["ADORA1"]
ADORA1 -->|"activates"| Als["Als"]
ADORA1 -->|"activates"| Ms["Ms"]
ADORA1 -->|"activates"| Alzheimer["Alzheimer"]
ADORA1 -->|"expressed in"| ADORA3["ADORA3"]
ADORA1 -->|"activates"| ALZHEIMER["ALZHEIMER"]
ADORA1 -->|"activates"| TAU["TAU"]
ADORA1 -->|"expressed in"| MAPT["MAPT"]
ADORA1 -->|"activates"| MEF2C["MEF2C"]
ASTROCYTE["ASTROCYTE"] -->|"activates"| ADORA1
LCN2["LCN2"] -->|"activates"| ADORA1
ALZHEIMER -->|"activates"| ADORA1
MEF2C -->|"activates"| ADORA1
MAPT -->|"expressed in"| ADORA1
NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"] -->|"activates"| ADORA1
TAU_PATHOLOGY["TAU PATHOLOGY"] -->|"activates"| ADORA1
AND["AND"] -->|"expressed in"| ADORA1| Source | Relation | Type | Str |
|---|---|---|---|
| Caffeine | inhibits | drug | 0.95 |
| MAPT | upregulates | gene | 0.90 |
| adenosine | activates | compound | 0.90 |
| MIR133A | downregulates | gene | 0.85 |
| MEF2C | activates | gene | 0.60 |
| MAPT | expressed_in | gene | 0.60 |
| ASTROCYTE | activates | gene | 0.60 |
| LCN2 | activates | gene | 0.60 |
| ALZHEIMER | activates | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | activates | gene | 0.60 |
| TAU PATHOLOGY | activates | gene | 0.60 |
| AND | expressed_in | gene | 0.60 |
| benchmark_ot_ad_answer_key:ADORA1 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||