Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about adora2b: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ADORA2B |
| Chromosome | 17p12 |
| Protein Type | Receptor |
| Function | encodes a G protein-coupled receptor that plays important roles in modulating cellular responses to adenosine. |
| Primary Expression | astrocytes, microglia, neurons, and endothelial cells of the [ |
| Molecular Weight | 44 kDa |
| Pathways | PI3K, MAPK Pathway, NF-κB Pathway, NF-κB |
| UniProt ID | P29274 |
| NCBI Gene ID | 136 |
| Ensembl ID | ENSG00000171490 |
| OMIM | 600446 |
| GeneCards | ADORA2B |
| Human Protein Atlas | ADORA2B |
| Associated Diseases | Als, Inflammation, ALS, neurodegeneration |
| Interactions | P2RX7, P2RY12, P2RX5, P2RX4, P2RY1, P2RX1 |
| KG Connections | 9 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
ADORA2B["ADORA2B"]
ADORA2B -->|"expressed in"| immune_cells["immune cells"]
ADORA2B -->|"activates"| AMPK["AMPK"]
ADORA2B -->|"binds"| netrin_1["netrin-1"]
ADORA2B -->|"upregulates"| hypoxia["hypoxia"]
ADORA2B -->|"contributes to"| immune_suppression["immune suppression"]
ADORA2B -->|"downregulates"| mGluR5["mGluR5"]
ADORA2B -->|"regulates"| inflammation["inflammation"]
ADORA2B -->|"activates"| Covid["Covid"]
P2RY1["P2RY1"] -->|"activates"| ADORA2B
P2RX7["P2RX7"] -->|"activates"| ADORA2B
P2RY12["P2RY12"] -->|"activates"| ADORA2B
P2RX5["P2RX5"] -->|"activates"| ADORA2B
GENES["GENES"] -->|"activates"| ADORA2B
P2RX4["P2RX4"] -->|"activates"| ADORA2B
PANX1["PANX1"] -->|"activates"| ADORA2B
P2RX1["P2RX1"] -->|"activates"| ADORA2B| Source | Relation | Type | Str |
|---|---|---|---|
| Caffeine | inhibits | drug | 0.95 |
| P2RY1 | activates | gene | 0.60 |
| P2RX7 | activates | gene | 0.60 |
| CD38 | associated_with | gene | 0.60 |
| P2RY12 | activates | gene | 0.60 |
| P2RX5 | activates | gene | 0.60 |
| P2RX4 | activates | gene | 0.60 |
| PANX1 | activates | gene | 0.60 |
| P2RX1 | activates | gene | 0.60 |
| ATP | associated_with | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| NAD | associated_with | gene | 0.60 |
| INFLAMMATION | associated_with | gene | 0.60 |
| AND | activates | gene | 0.60 |
| benchmark_ot_ad_answer_key:ADORA2B | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||