COMPLEMENT C3

Understanding Entity Pages

This page aggregates everything SciDEX knows about COMPLEMENT C3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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graph TD
    COMPLEMENT_C3["COMPLEMENT C3"]
    COMPLEMENT_C3 -->|"product_of"| C3A_FRAGMENT["C3A FRAGMENT"]
    COMPLEMENT_C3 -->|"contributes to"| Demyelination["Demyelination"]
    COMPLEMENT_C3 -->|"causes"| Astrocyte_Injury["Astrocyte Injury"]
    COMPLEMENT_C3 -->|"activates"| Microglial_Activation["Microglial Activation"]
    COMPLEMENT_C3 -->|"involved_in"| Astrocyte_Microglia_Crosstalk["Astrocyte-Microglia Crosstalk"]
    COMPLEMENT_C3 -->|"interacts"| C3aR["C3aR"]
    COMPLEMENT_C3 -->|"binds"| CR3["CR3"]
    COMPLEMENT_C3 -->|"exacerbates"| __Synuclein["alpha-Synuclein"]
    CR2_Crry["CR2-Crry"] -->|"inhibits"| COMPLEMENT_C3
    Astrocytes["Astrocytes"] -->|"product_of"| COMPLEMENT_C3
    Complement_C1q["Complement C1q"] -->|"activates"| COMPLEMENT_C3
    TLR2["TLR2"] -->|"regulates"| COMPLEMENT_C3
    NF__B["NF-kappaB"] -->|"regulates"| COMPLEMENT_C3