Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DLX1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | DLX1 |
| Chromosome | 2q31.1 |
| Protein Type | Gene |
| Function | DLX1 (Distal-Less Homeobox 1) encodes a homeobox transcription factor essential for embryonic development of the forebrain and craniofacial structures. |
| Primary Expression | developing GABAergic interneurons of the basal ganglia, cortex, and hippocampus, where it promo |
| Pathways | oxidative stress response |
| GeneCards | DLX1 |
| Human Protein Atlas | DLX1 |
| Associated Diseases | neurodegeneration |
| Interactions | IL1B, TNFA |
| KG Connections | 8 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
DLX1["DLX1"]
style DLX1 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff
IL1B["IL1B"]
TNFA["TNFA"]
neuroinflammation["neuroinflammation"]
oxidative_stress_response(("oxidative stress response"))
microglia["/"microglia"/"]
neurons["/"neurons"/"]
LHX6["LHX6"]
neurodegeneration["neurodegeneration"]
DLX1 -->|"activates"| IL1B
DLX1 -->|"activates"| TNFA
DLX1 -->|"activates"| neuroinflammation
DLX1 -->|"participates_in"| oxidative_stress_response
DLX1 -->|"expressed_in"| microglia
DLX1 -->|"expressed_in"| neurons
DLX1 -->|"associated_with"| LHX6
DLX1 -->|"implicated_in"| neurodegeneration
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef drug fill:#1a2a2a,stroke:#80cbc4,color:#e0e0e0
class IL1B gene
class TNFA gene
class neuroinflammation protein
class oxidative_stress_response pathway
class microglia mechanism
class neurons mechanism
class LHX6 gene
class neurodegeneration disease| Target | Relation | Type | Str |
|---|---|---|---|
| IL1B | activates | gene | 0.55 |
| TNFA | activates | gene | 0.55 |
| neuroinflammation | activates | disease | 0.55 |
| LHX6 | associated_with | gene | 0.55 |
| oxidative stress response | participates_in | pathway | 0.55 |
| microglia | expressed_in | cell_type | 0.55 |
| neurons | expressed_in | cell_type | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| h-0bdc3803 | targets | hypothesis | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-03 | 7 hypotheses Top: 0.527
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||