gene

TNFA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TNFA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

434Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

Summary

TNFA is a gene implicated in neurodegeneration research. Key relationships include: associated with, causes, co discussed. Associated with Aging, Als, Alzheimer. Connected to 113 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	TNF
Full Name	Tumor Necrosis Factor Alpha
Chromosome	6p21.33
Protein Family	TNF superfamily
Protein Type	Signaling Protein
Target Class	Signaling Protein
Function	Monoclonal antibodies or soluble receptors that neutralize TNF-alpha activity
Mechanism of Action	Monoclonal antibodies or soluble receptors that neutralize TNF-alpha activity
Druggability	Medium (0.50)
Clinical Stage	Approved
Molecular Weight	26 kDa
Exons	3
Pathways	Glucocorticoid receptor / stress response
UniProt ID	P01375
NCBI Gene ID	7124
Ensembl ID	ENSG00000232810
OMIM	191160
GeneCards	TNF
Human Protein Atlas	TNF
Associated Diseases	ALS, Aging, Alzheimer, Cancer, Cardiovascular
Known Drugs/Compounds	curcumin, resveratrol, rapamycin
Interactions	NR3C1, CRH, IL1B, IL12A, RIPK3, STAT3
SciDEX Target	View Target Profile (8 clinical trials)
KG Connections	434 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TNFA — AlphaFold P01375 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TNFA["TNFA"] -->|"associated"| neurodegeneration["neurodegeneration"]
    TNFA["TNFA"] -->|"interacts"| NR3C1["NR3C1"]
    TNFA["TNFA"] -->|"interacts"| CRH["CRH"]
    TNFA["TNFA"] -->|"co discussed"| PPARGC1A["PPARGC1A"]
    TNFA["TNFA"] -->|"co discussed"| PRKAA1["PRKAA1"]
    TNFA["TNFA"] -->|"co discussed"| NR3C1_1["NR3C1"]
    NR3C1_2["NR3C1"] -->|"interacts"| TNFA["TNFA"]
    CRH_3["CRH"] -->|"interacts"| TNFA["TNFA"]
    FOXP3["FOXP3"] -->|"co discussed"| TNFA["TNFA"]
    style TNFA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (249)

Target	Relation	Type	Str
Neuroinflammation	mediates	process	0.90
A1 astrocyte	causes	cell_type	0.80
RGC death	causes	biological_process	0.80
A1 astrocyte	inhibits	cell_type	0.80
Cancer	associated_with	disease	0.75
Tumor	associated_with	disease	0.75
CANCER	associated_with	gene	0.70
Stem Cell	associated_with	pathway	0.70
Parkinson	causes	disease	0.65
Aging	causes	disease	0.65
Inflammation	causes	disease	0.65
Alzheimer	causes	disease	0.65
Neurodegeneration	causes	disease	0.65
Colorectal Cancer	associated_with	disease	0.65
Inflammatory Bowel Disease	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Als	associated_with	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Senescence	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Rheumatoid Arthritis	therapeutic_target	disease	0.65
Ms	causes	disease	0.65
Als	activates	disease	0.65
Depression	regulates	disease	0.65
Neurodegeneration	activates	disease	0.65
Aging	activates	disease	0.65
Alzheimer	activates	disease	0.65
Parkinson	activates	disease	0.65
ALS	associated_with	disease	0.65
Anxiety	regulates	disease	0.65
ALS	activates	disease	0.65
microglia	expressed_in	cell_type	0.65
neurons	expressed_in	cell_type	0.65
KCNK2	regulates	gene	0.64
TRPA1	activates	gene	0.64
TRPM8	activates	gene	0.64
neurodegeneration	associated_with	disease	0.61
NR3C1	interacts_with	gene	0.61
CRH	interacts_with	gene	0.61
Glucocorticoid receptor / stress response	participates_in	pathway	0.61
neurodegeneration	implicated_in	disease	0.60
STAT3	causes	gene	0.60
IL1B	activates	gene	0.60
FYN	causes	gene	0.60
IL12A	activates	gene	0.60
STAT3	associated_with	gene	0.60

Incoming (185)

Source	Relation	Type	Str
high glucose	upregulates	compound	0.90
h-1e564178	targets_gene	hypothesis	0.90
h-cc1076c1	targets_gene	hypothesis	0.90
Glucose	upregulates	compound	0.85
h-1e564178	targets	hypothesis	0.80
IL1B	co_mentioned_with	gene	0.80
OCULAR HYPERTENSION	upregulates	biological_process	0.80
NR3C1	interacts_with	gene	0.61
CRH	interacts_with	gene	0.61
RIPK2	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
TREM2	associated_with	gene	0.60
IL6	therapeutic_target	gene	0.60
SIRT1	associated_with	gene	0.60
STING	associated_with	gene	0.60
NOD2	activates	gene	0.60
TNF	activates	gene	0.60
FYN	activates	gene	0.60
STAT3	activates	gene	0.60
IL1B	activates	gene	0.60
IL1B	associated_with	gene	0.60
TGFB1	associated_with	gene	0.60
C3AR1	associated_with	gene	0.60
LC3	associated_with	gene	0.60
ERN1	associated_with	gene	0.60
PYCARD	associated_with	gene	0.60
NOD2	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
BRG1	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
STAT3	associated_with	gene	0.60
MELK	associated_with	gene	0.60
SMARCA4	associated_with	gene	0.60
IL6	regulates	gene	0.60
NR3C1	activates	gene	0.60
STAT3	causes	gene	0.60
IL12A	activates	gene	0.60
FYN	causes	gene	0.60
IL6	associated_with	gene	0.60
APOE	associated_with	gene	0.60
EPHB4	associated_with	gene	0.60
USH2A	associated_with	gene	0.60
ADAM17	associated_with	gene	0.60
HMGB1	associated_with	gene	0.60
C3	regulates	gene	0.60
HMGB1	regulates	gene	0.60
SIRT1	regulates	gene	0.60
STING	regulates	gene	0.60
curcumin	regulates	compound	0.60
resveratrol	regulates	compound	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Neuroinflammation and microglial priming in early Alzheimer's Disease

neurodegeneration | 2026-04-04 | 14 hypotheses Top: 0.508

Digital biomarkers and AI-driven early detection of neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.605

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

TNFA

Understanding Entity Pages

Summary

Wiki Pages (21)

Tumor Necrosis Factor Alpha (TNF-α) as a Neurodegenerative Disease Biomarker

Biomarkers of Alzheimer Disease

Biomarker-Therapeutic Development Nexus

Biomarkers in Neurodegeneration

Biomarkers for Parkinson's Disease

USH2A Protein

Biomarkers for Corticobasal Degeneration

Biomarkers for Progressive Supranuclear Palsy

Biomarker Discovery Framework for Neurodegenerative Diseases

TNF Gene

Biomarkers in Parkinsonian Syndromes (NCT06501469)

Biomarker-Based Classification of Corticobasal Syndrome

Apoptosis Pathways in Parkinson's Disease

Anti-Inflammatory Therapy for Neurodegeneration

MST4 Gene

Biomarker Validation Study for AD Combination Therapy

AD vs PD Neuroinflammation Comparison Matrix

Biomarker Neuron Entities

TGFBI

NLRC3 — NLR Family CARD Domain Containing 3

Biomarkers to Distinguish FTLD-tau from FTLD-TDP