Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LHX6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
LHX6 encodes a LIM-type homeobox transcription factor critical for GABAergic interneuron development, cortical circuit formation, synaptic inhibition, and cognitive function, with emerging roles in neurodegenerative diseases including Alzheimer's and Parkinson's.
| Gene Symbol | LHX6 |
| Full Name | LIM Homeobox 6 |
| Chromosome | 9q33 |
| Protein Type | Transcription Factor |
| Function | encodes a LIM-type homeobox transcription factor that plays a fundamental role in the development of GABAergic inhibitory interneurons in the mammalian forebrain. |
| Primary Expression | specific interneuron populations, where it maintains aspects of interneuron identity and function |
| Molecular Weight | 43.8 kDa |
| Amino Acids | 406 aa |
| Pathways | Shh, BMP, Wnt |
| UniProt ID | Q9R0E3 |
| NCBI Gene ID | 26468 |
| Ensembl ID | ENSG00000106852 |
| OMIM | 608139 |
| GeneCards | LHX6 |
| Human Protein Atlas | LHX6 |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| KG Connections | 13 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
LHX6["LHX6"]
Als{"Als"}
LHX6 -->|"regulates"| Als
Diabetes{"Diabetes"}
LHX6 -->|"regulates"| Diabetes
Neuropathy{"Neuropathy"}
LHX6 -->|"regulates"| Neuropathy
IL_6["IL-6"]
LHX6 -->|"regulates"| IL_6
Neuron["Neuron"]
LHX6 -->|"regulates"| Neuron
Il_1("Il-1")
LHX6 -->|"regulates"| Il_1
IL_1["IL-1"]
IL_1 -->|"regulates"| LHX6
TRPV1["TRPV1"]
TRPV1 -->|"regulates"| LHX6
RNA["RNA"]
RNA -->|"regulates"| LHX6
ASCL1["ASCL1"]
ASCL1 -->|"regulates"| LHX6
CYTOKINES["CYTOKINES"]
CYTOKINES -->|"regulates"| LHX6
neurodegeneration["neurodegeneration"]
LHX6 -->|"implicated_in"| neurodegenerationHypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||