Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DNAJC1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | DNAJC1 |
| Full Name | DnaJ Heat Shock Protein Family (Hsp40) Member 1 |
| Chromosome | 10p13 |
| Protein Family | DnaJ/Hsp40 chaperone family |
| Protein Type | Chaperone |
| Function | DNAJC1 functions as a co-chaperone with broad specificity for Hsp70 family proteins: |
| Primary Expression | neurons across multiple re |
| Amino Acids | 354 aa |
| UniProt ID | Q9Y4F5 |
| NCBI Gene ID | 1557 |
| Ensembl ID | ENSG00000070214 |
| OMIM | 611452 |
| GeneCards | DNAJC1 |
| Human Protein Atlas | DNAJC1 |
| Gly/Phe-Rich Region | A flexible Gly/Phe-rich region links the J domain to the C-terminal substrate-binding domain. This region is variable in length and contributes to protein-protein interactions. |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
DNAJC1["DNAJC1"]
neurodegeneration["neurodegeneration"]
DNAJC1 -->|"implicated_in"| neurodegeneration
style DNAJC1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| No outgoing edges | |||
| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning DNAJC1 in their description or question text
No additional research found