gene 3,528 words KG: DNAJC13 2026-03-25
kind:genesection:genesstate:published
Contents

DNAJC13 — DnaJ Heat Shock Protein Family Member C13

🧬 Gene Info
Gene SymbolDNAJC13
Full NameDnaJ Heat Shock Protein Family Member C13
AliasesRME-8
Chromosome3q22.1
Protein TypeChaperone
Functionis a co-chaperone protein primarily localized to endosomal membranes where it functions as a critical regulator of endosomal trafficking and protein quality control.
Primary Expressionneurons throughout the brain, particularly in dopaminergic neurons of the substantia nigra pars compacta
Subcellular Localizationendosomal membranes where it functions as a critical regulator of endosomal trafficking and protein quality control. Ori
Molecular Weight280 kDa
Amino Acids558 aa
Exons33
PathwaysmTOR, mtor
GeneCardsDNAJC13
Human Protein AtlasDNAJC13
VariantInheritance
Associated DiseasesAls, Alzheimer, Parkinson, Parkinson's disease
KG Connections45 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (17)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.53
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
Excitatory Neuron Vulnerability via SLC17A7 Downregulation
Score: 0.44
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66

Related Analyses (7)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (15)

LRRK2 G2019S Transgenic Mouse Model
model · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: associated_with
VPS13C Gene - Vacuolar Protein Sorting 13 Homolog C
gene · KG edge: associated_with
SNCA — Alpha-Synuclein
gene · KG edge: associated_with

Knowledge Graph (12 edges)

DNAJC13 associated_with FBXO7
DNAJC13 associated_with PINK1
DNAJC13 associated_with VPS13C
DNAJC13 associated_with DNAJC6
DNAJC13 associated_with ATP13A2
DNAJC13 associated_with PLA2G6
DNAJC13 associated_with PRKN
DNAJC13 associated_with ATP1A3
DNAJC13 associated_with SNCA
DNAJC13 associated_with LRRK2