Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DYNC1I1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | DYNC1I1 |
| Full Name | Cytoplasmic Dynein 1 Intermediate Chain 1 |
| Chromosome | 7p21.1 |
| Function | encodes a critical subunit of the cytoplasmic dynein-1 motor complex, the primary molecular motor responsible for retrograde axonal transport in neurons. |
| Gene Type | Protein coding |
| UniProt ID | Q13418 |
| NCBI Gene ID | 1780 |
| Ensembl ID | ENSG00000111595 |
| OMIM | 617305 |
| GeneCards | DYNC1I1 |
| Human Protein Atlas | DYNC1I1 |
| :--- | :--- |
| Associated Diseases | neurodegeneration |
| KG Connections | 14 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
DYNC1I1["DYNC1I1"]
Tumor{"Tumor"}
DYNC1I1 -->|"protects_against"| Tumor
Neuron["Neuron"]
DYNC1I1 -->|"protects_against"| Neuron
AND["AND"]
DYNC1I1 -->|"expressed_in"| AND
TGM2["TGM2"]
DYNC1I1 -->|"expressed_in"| TGM2
IGF2["IGF2"]
DYNC1I1 -->|"expressed_in"| IGF2
Igf("Igf")
DYNC1I1 -->|"expressed_in"| Igf
App("App")
DYNC1I1 -->|"protects_against"| App
TGM2 -->|"expressed_in"| DYNC1I1
IGF2 -->|"expressed_in"| DYNC1I1
GENES["GENES"]
GENES -->|"protects_against"| DYNC1I1
DYNC1I1 -->|"expressed_in"| Neuron
GENE_EXPRESSION["GENE EXPRESSION"]
DYNC1I1 -->|"expressed_in"| GENE_EXPRESSION
neurodegeneration["neurodegeneration"]
DYNC1I1 -->|"implicated_in"| neurodegeneration| Target | Relation | Type | Str |
|---|---|---|---|
| Tumor | protects_against | disease | 0.65 |
| TGM2 | expressed_in | gene | 0.60 |
| IGF2 | expressed_in | gene | 0.60 |
| IGF2 | protects_against | gene | 0.60 |
| TGM2 | protects_against | gene | 0.60 |
| Neuron | protects_against | cell_type | 0.60 |
| AND | expressed_in | gene | 0.60 |
| Igf | expressed_in | protein | 0.60 |
| App | protects_against | protein | 0.60 |
| Neuron | expressed_in | cell_type | 0.55 |
| GENE EXPRESSION | expressed_in | concept | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||