concept

GENE EXPRESSION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GENE EXPRESSION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

464Connections

0Hypotheses

19Analyses

26Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	GENE EXPRESSION

Wiki Pages (20)

Knowledge base pages for this entity

cbs-psp-daily-action-plan

therapeutic · 30834 words

→

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Pathway Diagram

graph TD
    GENE_EXPRESSION["GENE EXPRESSION"]
    style GENE_EXPRESSION fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    GENE_EXPRESSION -->|"involved_in"| Cell_Type_Specification["Cell Type Specification"]
    GENE_EXPRESSION -->|"correlates_with"| Clear_Cell_Renal_Cell_Carcinom["Clear-Cell Renal Cell Carcinoma"]
    GENE_EXPRESSION -->|"expressed in"| Disease_Vulnerable_Neurons["/Disease-Vulnerable Neurons/"]
    GENE_EXPRESSION -->|"activates"| alcohol_use_disorder["alcohol use disorder"]
    HDAC["HDAC"] -.->|"inhibits"| GENE_EXPRESSION
    TDP_43([TDP-43]) -->|"regulates"| GENE_EXPRESSION
    Circadian_Clock["Circadian Clock"] -->|"modulates"| GENE_EXPRESSION
    JAK([JAK]) -->|"regulates"| GENE_EXPRESSION
    Histone_Lactylation["Histone Lactylation"] -->|"regulates"| GENE_EXPRESSION
    JAK_STAT_Pathway["JAK/STAT Pathway"] -->|"regulates"| GENE_EXPRESSION
    Epigenetics["Epigenetics"] -->|"regulates"| GENE_EXPRESSION
    STAT3([STAT3]) -->|"regulates"| GENE_EXPRESSION
    Stress["Stress"] -->|"modulates"| GENE_EXPRESSION
    NCL([NCL]) -->|"regulates"| GENE_EXPRESSION

Outgoing (34)

Target	Relation	Type	Str
NUCLEUS	activates	concept	0.50
PEROXISOME	activates	concept	0.50
INTERNEURONS	interacts_with	concept	0.50
DENDRITIC CELLS	activates	concept	0.50
B CELLS	activates	concept	0.50
B CELLS	expressed_in	concept	0.50
NUCLEUS	inhibits	concept	0.50
NUCLEUS	expressed_in	concept	0.50
ORGANOIDS	activates	concept	0.50
ENTORHINAL CORTEX	expressed_in	concept	0.50
CARDIOMYOCYTES	regulates	concept	0.50
AUTOPHAGOSOME	activates	concept	0.50
STEM CELLS	activates	concept	0.50
EXTRACELLULAR VESICLES	activates	concept	0.50
NUCLEUS	interacts_with	concept	0.50
HEPATOCYTES	interacts_with	concept	0.50
MTOR SIGNALING	activates	concept	0.50
STEM CELLS	expressed_in	concept	0.50
INTERNEURONS	expressed_in	concept	0.50
SRPK1	expressed_in	concept	0.50
RESVERATROL	expressed_in	concept	0.50
AMYGDALA	expressed_in	concept	0.50
CHOLESTEROL METABOLISM	interacts_with	concept	0.50
TEMPORAL LOBE	expressed_in	concept	0.50
IPSC	regulates	concept	0.50
NEUTROPHILS	regulates	concept	0.50

Incoming (430)

Source	Relation	Type	Str
MUTANT IDH1	associated_with	entity	0.90
MUTANT IDH2	associated_with	entity	0.90
PGC-1Α	activates	protein	0.50
PPAR	activates	protein	0.50
GLUT4	activates	concept	0.50
MEF2C	interacts_with	gene	0.50
PGC-1Α	interacts_with	protein	0.50
NEURONS	interacts_with	concept	0.50
NADPH	activates	protein	0.50
NADH	activates	concept	0.50
CERS2	interacts_with	gene	0.50
IL-10	interacts_with	protein	0.50
CERAMIDE	interacts_with	concept	0.50
EPHB4	interacts_with	gene	0.50
EFNB1	interacts_with	gene	0.50
CELL CYCLE	interacts_with	cell_type	0.50
Epithelial Cell	interacts_with	cell_type	0.50
TARDBP	interacts_with	gene	0.50
Tdp-43	interacts_with	pathway	0.50
Rna Splicing	interacts_with	gene	0.50
disease	expressed_in	disease	0.50
Covid	expressed_in	disease	0.50
adora2b	activates	gene	0.50
P2RX7	activates	gene	0.50
P2RY12	activates	gene	0.50
P2RX5	activates	gene	0.50
P2RX4	activates	gene	0.50
P2RY1	activates	gene	0.50
P2RX1	activates	gene	0.50
PANX1	activates	gene	0.50
Covid	activates	disease	0.50
BMAL1	interacts_with	protein	0.50
CLOCK	interacts_with	gene	0.50
Neuroinflammatory	regulates	pathway	0.50
BMAL1	regulates	protein	0.50
CLOCK	regulates	gene	0.50
CLOCK GENE	regulates	concept	0.50
LIPID METABOLISM	interacts_with	pathway	0.50
CLOCK	expressed_in	gene	0.50
CLOCK GENE	expressed_in	concept	0.50
cancer	regulates	disease	0.50
Cell Division	regulates	pathway	0.50
NR3C1	expressed_in	gene	0.50
ESR1	expressed_in	gene	0.50
ESR2	expressed_in	gene	0.50
POMC	expressed_in	gene	0.50
CRHR1	expressed_in	gene	0.50
TNF ALPHA	expressed_in	protein	0.50
TUMOR	expressed_in	disease	0.50
FOXO1	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (19)

Scientific analyses that reference this entity

What are the cell-type-specific transcriptomic signatures of vulnerability in SE

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.576

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

neuroinflammation | 2026-04-15 | 1 hypotheses Top: 0.650

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

neuroinflammation | 2026-04-06 | 0 hypotheses

How do neurodegeneration gene expression patterns in SEA-AD differ from other po

neurodegeneration | 2026-04-04 | 1 hypotheses Top: 0.448

Which cell types show the most significant expression changes for neurodegenerat

neurodegeneration | 2026-04-03 | 7 hypotheses Top: 0.529

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

GENE EXPRESSION

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Progressive Supranuclear Palsy (PSP)

Parkinson's Disease

Sleep and Circadian Dysfunction in Alzheimer's Disease

Pathway Diagram

Outgoing (34)

Incoming (430)

Targeting Hypotheses (0)

Mentioning Analyses (19)

What are the cell-type-specific transcriptomic signatures of vulnerability in SE

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

How do neurodegeneration gene expression patterns in SEA-AD differ from other po

Which cell types show the most significant expression changes for neurodegenerat

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Related Papers (0)

GENE EXPRESSION

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Progressive Supranuclear Palsy (PSP)

Parkinson's Disease

Sleep and Circadian Dysfunction in Alzheimer's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

primary-progressive-aphasia

calcium-dysregulation-comparison

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Alpha-Synuclein Pathology

Corticobasal Degeneration (CBD)

nhp-validation-animal-model

nimodipine-als

Neuroresilience Mechanisms and Evidence

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

Frontotemporal Dementia (FTD) Mechanistic Pathway

neuroinflammation

CBS/PSP Treatment Rankings

NRF2 Oxidative Stress Pathway

Multiple System Atrophy

Pathway Diagram

Outgoing (34)

Incoming (430)

Targeting Hypotheses (0)

Mentioning Analyses (19)

What are the cell-type-specific transcriptomic signatures of vulnerability in SE

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

How do neurodegeneration gene expression patterns in SEA-AD differ from other po

Which cell types show the most significant expression changes for neurodegenerat

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Related Papers (0)