concept

IGF

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IGF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

249Connections

14Hypotheses

1Analyses

50Outgoing

50Incoming

1Experiments

1Debates

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💡 Concept Info

Name	IGF
Linked Hypotheses	17 hypotheses

Wiki Pages (14)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    IGF["IGF"]
    style IGF fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    IGF -->|"target for"| Als["Als"]
    IGF -->|"regulates"| Fibrosis["Fibrosis"]
    IGF -->|"target for"| Aging["Aging"]
    IGF -->|"target for"| Neurodegeneration["Neurodegeneration"]
    IGF -->|"target for"| Cancer["Cancer"]
    IGF -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    ROS([ROS]) -->|"regulates"| IGF
    HSPG2([HSPG2]) -->|"regulates"| IGF
    RNA([RNA]) -->|"regulates"| IGF
    DAG1([DAG1]) -->|"regulates"| IGF
    BAD([BAD]) -->|"regulates"| IGF
    IGF1R([IGF1R]) -->|"regulates"| IGF
    YTHDF1([YTHDF1]) -->|"target for"| IGF
    IGF2BP1([IGF2BP1]) -->|"target for"| IGF
    TDP_43([TDP-43]) -->|"target for"| IGF
    ELAVL2([ELAVL2]) -->|"target for"| IGF

Outgoing (62)

Target	Relation	Type	Str
Als	associated_with	disease	0.60
Fibrosis	regulates	disease	0.60
Aging	therapeutic_target	disease	0.60
Neurodegeneration	therapeutic_target	disease	0.60
Neuroinflammation	regulates	disease	0.60
Neurodegeneration	associated_with	disease	0.60
Alzheimer	activates	disease	0.60
Als	inhibits	disease	0.60
Atherosclerosis	therapeutic_target	disease	0.60
Senescence	biomarker_for	disease	0.60
Aging	biomarker_for	disease	0.60
Fibrosis	biomarker_for	disease	0.60
Aging	associated_with	disease	0.60
Atherosclerosis	associated_with	disease	0.60
Senescence	activates	disease	0.60
Cancer	activates	disease	0.60
Senescence	associated_with	disease	0.60
Diabetes	activates	disease	0.60
Glioblastoma	expressed_in	disease	0.60
Cancer	expressed_in	disease	0.60
Neuroinflammation	expressed_in	disease	0.60
Alzheimer	expressed_in	disease	0.60
Aging	regulates	disease	0.60
Als	therapeutic_target	disease	0.60
Als	interacts_with	disease	0.60
Cancer	associated_with	disease	0.60
Als	causes	disease	0.60
Als	activates	disease	0.60
Aging	activates	disease	0.60
Amyotrophic Lateral Sclerosis	associated_with	disease	0.60
Parkinson	associated_with	disease	0.60
Huntington	associated_with	disease	0.60
Alzheimer	associated_with	disease	0.60
Diabetes	associated_with	disease	0.60
Alzheimer	therapeutic_target	disease	0.60
Fibrosis	activates	disease	0.60
Anxiety	regulates	disease	0.60
Alzheimer	regulates	disease	0.60
Depression	activates	disease	0.60
Neurodegeneration	activates	disease	0.60
Cancer	therapeutic_target	disease	0.60
Neurogenesis	activates	pathway	0.55
Mapk	therapeutic_target	pathway	0.55
Autophagy	therapeutic_target	pathway	0.55
Wnt	therapeutic_target	pathway	0.55
Mtor	therapeutic_target	pathway	0.55
Mapk	expressed_in	pathway	0.55
Mtor	regulates	pathway	0.55
Innate Immunity	therapeutic_target	pathway	0.55
Nf-Κb	activates	pathway	0.55

Incoming (187)

Source	Relation	Type	Str
MAPK	therapeutic_target	gene	0.60
AUTOPHAGY	therapeutic_target	gene	0.60
METTL3	therapeutic_target	gene	0.60
IGF2R	interacts_with	gene	0.60
ENDOSOMES	interacts_with	gene	0.60
ATP6V1G1	activates	gene	0.60
RAB7A	causes	gene	0.60
YAP	activates	gene	0.60
RILP	activates	gene	0.60
IGF2R	causes	gene	0.60
ENDOSOMES	activates	gene	0.60
RAB7	causes	gene	0.60
IGF2	activates	gene	0.60
ALS	activates	gene	0.60
JUN	expressed_in	gene	0.60
IGF2R	expressed_in	gene	0.60
AGING	activates	gene	0.60
HUNTINGTON	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
IGF2R	therapeutic_target	gene	0.60
PD-L1	therapeutic_target	gene	0.60
IGF1	activates	gene	0.60
IGF1R	activates	gene	0.60
NINJ2	activates	gene	0.60
PDGFRB	activates	gene	0.60
AMYLOID	regulates	gene	0.60
TAU	regulates	gene	0.60
NR3C1	regulates	gene	0.60
ANXIETY	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
ONCOGENES	activates	gene	0.60
IGF2BP2	activates	gene	0.60
BRD4	inhibits	gene	0.60
KLF7	activates	gene	0.60
CPLX3	inhibits	gene	0.60
OPRL1	expressed_in	gene	0.60
GLIOBLASTOMA	expressed_in	gene	0.60
HCRTR1	inhibits	gene	0.60
GBM	inhibits	gene	0.60
MAPK	expressed_in	gene	0.60
LRRTM2	expressed_in	gene	0.60
APP/PS1	expressed_in	gene	0.60
IGF1	contributes_to	gene	0.60
LNCRNA	expressed_in	gene	0.60
RNA	contributes_to	gene	0.60
EGFR	contributes_to	gene	0.60
SERPINE1	contributes_to	gene	0.60
HMOX1	contributes_to	gene	0.60
P2RX7	contributes_to	gene	0.60

Targeting Hypotheses (14)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
AAV-PHP.eB-Mediated Microglial IGFBPL1 Expression	0.768	drug-delivery	Can IGFBPL1 therapeutics effectively cro
IGFBPL1-Mediated Homeostatic Restoration	0.584	alzheimers	Neuroinflammation and microglial priming
IGFBPL1-Mediated Microglial Reprogramming	0.579	neurodegeneration	Neuroinflammation and microglial priming
Fusing IGFBPL1 to IGF-1 for Receptor-Mediated BBB Transcytos	0.552	drug-delivery	Can IGFBPL1 therapeutics effectively cro
Lipid Nanoparticle Encapsulation of IGFBPL1-mRNA	0.527	drug-delivery	Can IGFBPL1 therapeutics effectively cro

Intranasal IGFBPL1 Delivery via Olfactory Pathway	0.459	drug-delivery	Can IGFBPL1 therapeutics effectively cro
IGFBPL1 Peptide Mimetics for Drug-Like BBB Permeability	0.397	drug-delivery	Can IGFBPL1 therapeutics effectively cro
FUS-Enhanced AAV-PHP.eB Delivery for Microglial IGFBPL1 Expr	0.380	drug-delivery	Can IGFBPL1 therapeutics effectively cro
Activity-Dependent Synaptic Tagging via CREB-IGF1-IGF1R Sign	0.380	synaptic-biology	What determines the selectivity of compl
Lentiviral-Mediated Astrocytic IGFBPL1 Expression via GFAP P	0.380	drug-delivery	Can IGFBPL1 therapeutics effectively cro
AAV-PHP.eB-Mediated Astrocytic IGFBPL1 Expression	0.359	drug-delivery	Can IGFBPL1 therapeutics effectively cro
Magnetofection-Enhanced IGFBPL1 Delivery via Superparamagnet	0.341	drug-delivery	Can IGFBPL1 therapeutics effectively cro
FUS-Enhanced AAV-PHP.eB Delivery of IGFBPL1 to Microglia	0.338	drug-delivery	Can IGFBPL1 therapeutics effectively cro
IGFBPL1-Mediated Microglial Homeostasis Reset Therapy	0.000	-	Neuroinflammation and microglial priming

Mentioning Analyses (1)

Scientific analyses that reference this entity

Can IGFBPL1 therapeutics effectively cross the blood-brain barrier to reach CNS

drug delivery | 2026-04-06 | 13 hypotheses Top: 0.768

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
bEV-mediated synaptic pruning via C1q-C3 pathway	exploratory	Alzheimer's disease	0.850	0.00	microglia and synapses (in viv	proposed	N/A

Related Papers (12)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Insulin-Like Growth Factor Signaling in Alzheimer's Disease: Pathophysiology and [PMID:39240280]	Miao J, Zhang Y, Su C, Zheng Q, Guo J	Molecular neurobiology	2025	1
IGF2BP1 exacerbates neuroinflammation and cerebral ischemia/reperfusion injury b [PMID:40294852]	Li Y, Jiang J, Zhuo Y, Li J, Li Y, Xia Y	Biochimica et biophysica acta.	2025	1
Functional assessments through novel proteomics approaches: Application to insul [PMID:30412730]	Ayyadevara S, Ganne A, Hendrix RD, Balas	Journal of neuroscience method	2019	1
Neuronal functions of FOXO/DAF-16. [PMID:28447066]	Kim SY, Webb AE	Nutrition and healthy aging	2017	1
Caloric restriction. [PMID:21840335]	Speakman JR, Mitchell SE	Molecular aspects of medicine	2011	1
Microglia-mediated IGF-I neuroprotection in the rd10 mouse model of retinitis pi [PMID:22039242]	Arroba AI, Alvarez-Lindo N, van Rooijen	Investigative ophthalmology &	2011	1
Semaglutide treatment reverses HFD induced hippocampal microglia activation and [PMID:41916100]	["Gong Haodong", "Liu Junlu", "Wang Yiha	Tissue & cell	2026	0
Focused ultrasound-mediated APOE4 knockdown in mouse brain. [PMID:40665471]	Zheng K, Tsitsos FN, Batts AJ, Ji R, Nur	Alzheimer's & dementia : the j	2025	0
Focused ultrasound widely broadens AAV-delivered Cas9 distribution and activity. [PMID:39893321]	Gumusgoz E, Kasiri S, Youssef I, Verma M	Gene therapy	2025	0
α-Synuclein oligomers potentiate neuroinflammatory NF-κB activity and induce Ca [PMID:38378800]	["Leandrou Emmanouela", "Chalatsa Ioanna	Translational neurodegeneratio	2024	0
IGFBPL1 is a master driver of microglia homeostasis and resolution of neuroinfla [PMID:37527036]	Pan L, Cho KS, Wei X, Xu F, Lennikov A,	Cell reports	2023	0
Incisionless targeted adeno-associated viral vector delivery to the brain by foc [PMID:36152518]	Unknown	EBioMedicine	2022	0

Debates (1)

Multi-agent debates referencing this entity

The debate highlighted IGFBPL1's potential as a microglial master regulator but

closed · Rounds: 4 · Score: 0.69 · 2026-04-22

Related Research

Hypotheses and analyses mentioning IGF in their description or question text

Intranasal IGFBPL1 Delivery via Olfactory Pathway

Score: 0.459 · drug-delivery · 2026-04-22

## Mechanistic Overview Intranasal IGFBPL1 Delivery via Olfactory Pathway starts from the claim that modulating IGFBPL1

IGFBPL1 Peptide Mimetics for Drug-Like BBB Permeability

Score: 0.397 · drug-delivery · 2026-04-22

## Mechanistic Overview IGFBPL1 Peptide Mimetics for Drug-Like BBB Permeability starts from the claim that modulating IG

FUS-Enhanced AAV-PHP.eB Delivery for Microglial IGFBPL1 Expression

Score: 0.380 · drug-delivery · 2026-04-27

This hybrid approach combines focused ultrasound (FUS) microbubble-mediated blood-brain barrier (BBB) disruption with AA

Activity-Dependent Synaptic Tagging via CREB-IGF1-IGF1R Signaling

Score: 0.380 · synaptic-biology · 2026-04-27

The activity-dependent synaptic tagging mechanism operates through coordinated interplay of CREB1, IGF1 (insulin-like gr

Lentiviral-Mediated Astrocytic IGFBPL1 Expression via GFAP Promoter

Score: 0.380 · drug-delivery · 2026-04-27

**Molecular Mechanism and Rationale** The lentiviral-mediated delivery of IGFBPL1 to astrocytes utilizes the neurotropi

AAV-PHP.eB-Mediated Astrocytic IGFBPL1 Expression

Score: 0.359 · drug-delivery · 2026-04-26

**Molecular Mechanism and Rationale** The AAV-PHP.eB-mediated delivery of IGFBPL1 to astrocytes leverages the neurotrop

Magnetofection-Enhanced IGFBPL1 Delivery via Superparamagnetic Iron Oxide Nanopa

Score: 0.341 · drug-delivery · 2026-04-26

The molecular foundation of magnetofection-mediated IGFBPL1 delivery exploits superparamagnetic iron oxide nanoparticles

FUS-Enhanced AAV-PHP.eB Delivery of IGFBPL1 to Microglia

Score: 0.338 · drug-delivery · 2026-04-26

This hypothesis combines focused ultrasound (FUS) microbubble-mediated blood-brain barrier disruption with AAV-PHP.eB vi

IGFBPL1-Mediated Microglial Homeostasis Reset Therapy

Score: 0.000 · unknown disease · 2026-04-28

Targeted delivery of IGFBPL1 or its functional mimetics could serve as a master switch to restore microglial homeostasis

IGF

Understanding Entity Pages

Wiki Pages (14)

Expanded to 3000+ words

IGF-1 Signaling Pathway in Neurodegeneration

IGF2BP3 — Insulin-Like Growth Factor 2 mRNA-Binding Protein 3

IGF2 Protein (Insulin-like Growth Factor 2)

Insulin and IGF Signaling in 4R-Tauopathies

IGF2BP2

IGF2BP1

IGF2BP1 Protein

IGF2R Protein

IGF1 Gene

IGF2 (Insulin-Like Growth Factor 2)

IGF2BP2 Protein

IGF1R Gene

IGF-1 Receptor Neurons