concept

IGF

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IGF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

250Connections

2Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

No summary available yet. View on Wiki →

💡 Concept Info

Name	IGF
Linked Hypotheses	4 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    IGF["IGF"]
    style IGF fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    IGF -->|"target for"| Als["Als"]
    IGF -->|"regulates"| Fibrosis["Fibrosis"]
    IGF -->|"target for"| Aging["Aging"]
    IGF -->|"target for"| Neurodegeneration["Neurodegeneration"]
    IGF -->|"target for"| Cancer["Cancer"]
    IGF -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    ROS([ROS]) -->|"regulates"| IGF
    HSPG2([HSPG2]) -->|"regulates"| IGF
    RNA([RNA]) -->|"regulates"| IGF
    DAG1([DAG1]) -->|"regulates"| IGF
    BAD([BAD]) -->|"regulates"| IGF
    IGF1R([IGF1R]) -->|"regulates"| IGF
    YTHDF1([YTHDF1]) -->|"target for"| IGF
    IGF2BP1([IGF2BP1]) -->|"target for"| IGF
    TDP_43([TDP-43]) -->|"target for"| IGF
    ELAVL2([ELAVL2]) -->|"target for"| IGF

Outgoing (63)

Target	Relation	Type	Str
Als	therapeutic_target	disease	0.60
Fibrosis	regulates	disease	0.60
Aging	therapeutic_target	disease	0.60
Neurodegeneration	therapeutic_target	disease	0.60
Als	interacts_with	disease	0.60
Cancer	associated_with	disease	0.60
Als	causes	disease	0.60
Als	activates	disease	0.60
Aging	activates	disease	0.60
Amyotrophic Lateral Sclerosis	associated_with	disease	0.60
Parkinson	associated_with	disease	0.60
Huntington	associated_with	disease	0.60
Alzheimer	associated_with	disease	0.60
Cancer	therapeutic_target	disease	0.60
Diabetes	associated_with	disease	0.60
Neuroinflammation	regulates	disease	0.60
Neurodegeneration	associated_with	disease	0.60
Alzheimer	activates	disease	0.60
Als	inhibits	disease	0.60
Atherosclerosis	therapeutic_target	disease	0.60
Senescence	biomarker_for	disease	0.60
Aging	biomarker_for	disease	0.60
Fibrosis	biomarker_for	disease	0.60
Fibrosis	activates	disease	0.60
Anxiety	regulates	disease	0.60
Alzheimer	regulates	disease	0.60
Aging	associated_with	disease	0.60
Atherosclerosis	associated_with	disease	0.60
Senescence	activates	disease	0.60
Depression	activates	disease	0.60
Neurodegeneration	activates	disease	0.60
Cancer	activates	disease	0.60
Als	associated_with	disease	0.60
Senescence	associated_with	disease	0.60
Diabetes	activates	disease	0.60
Glioblastoma	expressed_in	disease	0.60
Cancer	expressed_in	disease	0.60
Als	contributes_to	disease	0.60
Neuroinflammation	expressed_in	disease	0.60
Alzheimer	expressed_in	disease	0.60
Alzheimer	therapeutic_target	disease	0.60
Aging	regulates	disease	0.60
Mapk	therapeutic_target	pathway	0.55
Autophagy	therapeutic_target	pathway	0.55
Wnt	therapeutic_target	pathway	0.55
Mtor	therapeutic_target	pathway	0.55
Neurogenesis	interacts_with	pathway	0.55
Oxidative Stress	activates	pathway	0.55
Apoptosis	regulates	pathway	0.55
Innate Immunity	therapeutic_target	pathway	0.55

Incoming (187)

Source	Relation	Type	Str
ROS	regulates	gene	0.60
HSPG2	regulates	gene	0.60
RNA	regulates	gene	0.60
DAG1	regulates	gene	0.60
BAD	regulates	gene	0.60
IGF1R	regulates	gene	0.60
YTHDF1	therapeutic_target	gene	0.60
IGF2BP1	therapeutic_target	gene	0.60
TDP-43	therapeutic_target	gene	0.60
ELAVL2	therapeutic_target	gene	0.60
ALS	therapeutic_target	gene	0.60
FUS	therapeutic_target	gene	0.60
LONP1	therapeutic_target	gene	0.60
RAB11	therapeutic_target	gene	0.60
CLPP	therapeutic_target	gene	0.60
STX17	therapeutic_target	gene	0.60
AGING	therapeutic_target	gene	0.60
RAB5	therapeutic_target	gene	0.60
SNAP29	therapeutic_target	gene	0.60
BDNF	therapeutic_target	gene	0.60
MAPK	therapeutic_target	gene	0.60
AUTOPHAGY	therapeutic_target	gene	0.60
METTL3	therapeutic_target	gene	0.60
IGF2R	interacts_with	gene	0.60
ENDOSOMES	interacts_with	gene	0.60
ATP6V1G1	activates	gene	0.60
RAB7A	causes	gene	0.60
YAP	activates	gene	0.60
RILP	activates	gene	0.60
IGF2R	causes	gene	0.60
ENDOSOMES	activates	gene	0.60
RAB7	causes	gene	0.60
IGF2	activates	gene	0.60
ALS	activates	gene	0.60
JUN	expressed_in	gene	0.60
IGF2R	expressed_in	gene	0.60
AGING	activates	gene	0.60
HUNTINGTON	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
IGF2R	therapeutic_target	gene	0.60
PD-L1	therapeutic_target	gene	0.60
RNA	therapeutic_target	gene	0.60
ALKBH5	therapeutic_target	gene	0.60
WTAP	therapeutic_target	gene	0.60
FTO	therapeutic_target	gene	0.60
HNRNPA2B1	interacts_with	gene	0.60
RNA	interacts_with	gene	0.60
SYP	interacts_with	gene	0.60
IL-1	activates	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
IGFBPL1-Mediated Homeostatic Restoration	0.446	Alzheimer's disease	Neuroinflammation and microglial priming
IGFBPL1-Mediated Microglial Reprogramming	0.414	neurodegeneration	Neuroinflammation and microglial priming

Mentioning Analyses (1)

Scientific analyses that reference this entity

Can IGFBPL1 therapeutics effectively cross the blood-brain barrier to reach CNS

drug delivery | 2026-04-06 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (9)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Insulin-Like Growth Factor Signaling in Alzheimer's Disease: Pathophysiology and [PMID:39240280]	Miao J, Zhang Y, Su C, Zheng Q, Guo J	Molecular neurobiology	2025	1
IGF2BP1 exacerbates neuroinflammation and cerebral ischemia/reperfusion injury b [PMID:40294852]	Li Y, Jiang J, Zhuo Y, Li J, Li Y, Xia Y	Biochimica et biophysica acta.	2025	1
Functional assessments through novel proteomics approaches: Application to insul [PMID:30412730]	Ayyadevara S, Ganne A, Hendrix RD, Balas	Journal of neuroscience method	2019	1
Neuronal functions of FOXO/DAF-16. [PMID:28447066]	Kim SY, Webb AE	Nutrition and healthy aging	2017	1
Caloric restriction. [PMID:21840335]	Speakman JR, Mitchell SE	Molecular aspects of medicine	2011	1
Microglia-mediated IGF-I neuroprotection in the rd10 mouse model of retinitis pi [PMID:22039242]	Arroba AI, Alvarez-Lindo N, van Rooijen	Investigative ophthalmology &	2011	1
Semaglutide treatment reverses HFD induced hippocampal microglia activation and [PMID:41916100]	["Gong Haodong", "Liu Junlu", "Wang Yiha	Tissue & cell	2026	0
α-Synuclein oligomers potentiate neuroinflammatory NF-κB activity and induce Ca [PMID:38378800]	["Leandrou Emmanouela", "Chalatsa Ioanna	Translational neurodegeneratio	2024	0
IGFBPL1 is a master driver of microglia homeostasis and resolution of neuroinfla [PMID:37527036]	Pan L, Cho KS, Wei X, Xu F, Lennikov A,	Cell reports	2023	0

IGF

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Progressive Supranuclear Palsy (PSP)

Novel Therapy Index

Parkinson's Disease

nimodipine-als

Neuroresilience Mechanisms and Evidence

CBS/PSP Treatment Rankings

Alzheimer's Disease

nct07165106

Microglial Cells — Cell Type Hierarchy

GSK-3β in Neurodegeneration

Growth Factor Therapies

ALS Failed Approaches Analysis

Oligodendrocytes

Rapamycin ALS Trial - mTOR Inhibition for Amyotrophic Lateral Sclerosis

VEGF/Angiogenesis Pathway in Neurodegeneration

Insulin Signaling in Parkinson's Disease

Growth Factor Therapeutics: Investment Landscape Analysis

IGF-1 Signaling Pathway in Neurodegeneration

metabolic-dysfunction-neurodegeneration