Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about EPHB2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
EPHB2 (Eph Receptor B2) is a member of the Eph receptor tyrosine kinase family involved in synaptic plasticity, memory formation, and neurodegenerative disease pathogenesis.
| Gene Symbol | EPHB2 |
| Full Name | Eph Receptor B2 |
| Chromosome | 1p36.12 |
| Protein Type | Receptor |
| Function | is a member of the Eph receptor tyrosine kinase family that plays crucial roles in neural development, synaptic plasticity, and cellular communication within the central nervous system. |
| Primary Expression | the developing nervous system, where it plays critical roles in neuronal migration, axon guidance, and target selection |
| Molecular Weight | 110 kDa |
| UniProt ID | P29323 |
| NCBI Gene ID | 2048 |
| Ensembl ID | ENSG00000199639 |
| OMIM | 600036 |
| GeneCards | EPHB2 |
| Human Protein Atlas | EPHB2 |
| Associated Diseases | Alzheimer's disease, Parkinson's disease, deafness |
| Interactions | UBIQUITIN, FBXO45, MYC, EPHA5 |
| KG Connections | 6 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
EPHB2["<b>EPHB2</b>"]
Als{"Als"}
EPHB2 -->|"interacts with"| Als
Ms{"Ms"}
EPHB2 -->|"interacts with"| Ms
UBIQUITIN["UBIQUITIN"]
EPHB2 -->|"activates"| UBIQUITIN
neurodegeneration["neurodegeneration"]
EPHB2 -->|"implicated in"| neurodegeneration
EPHA5["EPHA5"]
EPHA5 -->|"phosphorylates"| EPHB2
FBXO45["FBXO45"]
FBXO45 -->|"interacts with"| EPHB2
MYC["MYC"]
MYC -->|"interacts with"| EPHB2
style EPHB2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||