EPHA5

Understanding Entity Pages

This page aggregates everything SciDEX knows about EPHA5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

EPHA5 (Eph Receptor A5) - a receptor tyrosine kinase highly expressed in hippocampus and cortex, involved in synaptic plasticity, learning and memory, and implicated in Alzheimer's disease and Parkinson's disease

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graph TD
    EPHA5["<b>EPHA5</b>"]
    EPHB2["EPHB2"]
    EPHA5 -->|"phosphorylates"| EPHB2
    Dectin_1["Dectin-1"]
    EPHA5 -->|"phosphorylates"| Dectin_1
    Wnt_signaling_pathway(["Wnt signaling pathway"])
    EPHA5 -->|"activates"| Wnt_signaling_pathway
    osteoblast_differentiation["osteoblast differentiation"]
    EPHA5 -->|"inhibits"| osteoblast_differentiation
    migraine{"migraine"}
    EPHA5 -->|"associated with"| migraine
    exceptional_response_to_cancer_therapy["exceptional response to cancer therapy"]
    EPHA5 -->|"associated with"| exceptional_response_to_cancer_therapy
    esophageal_adenocarcinoma{"esophageal adenocarcinoma"}
    EPHA5 -->|"associated with"| esophageal_adenocarcinoma
    Migraine{"Migraine"}
    EPHA5 -->|"associated with"| Migraine
    EP300["EP300"]
    EPHA5 -->|"associated with"| EP300
    NLGN2["NLGN2"]
    EPHA5 -->|"associated with"| NLGN2
    CDK4["CDK4"]
    EPHA5 -->|"associated with"| CDK4
    CHD4["CHD4"]
    EPHA5 -->|"associated with"| CHD4
    Dexamethasone["Dexamethasone"]
    Dexamethasone -->|"downregulates"| EPHA5
    c_Fos["c-Fos"]
    c_Fos -->|"upregulates"| EPHA5
    KCNK5["KCNK5"]
    KCNK5 -->|"associated with"| EPHA5
    TGFB1["TGFB1"]
    TGFB1 -->|"associated with"| EPHA5
    TP53["TP53"]
    TP53 -->|"associated with"| EPHA5
    NR1D1["NR1D1"]
    NR1D1 -->|"associated with"| EPHA5
    FXN["FXN"]
    FXN -->|"associated with"| EPHA5
    style EPHA5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0