protein

ERCC3PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ERCC3PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

ERCC3 forms the core of the TFIIH complex, which consists of seven subunits (XPB, XPD, p62, p52, p44, p34, and p8/GTF2H4).

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🔬 Protein Info

Gene Symbol	ERCC3PROTEIN
Chromosome	19q13.2
Function	is a critical DNA helicase and ATP-dependent 3'-5' translocase that functions as a core component of the TFIIH (Transcription Factor II H) complex.
Subcellular Localization	** \| Nucleus \|
Molecular Weight	89 kDa
Amino Acids	782 aa
GeneCards	ERCC3PROTEIN
Human Protein Atlas	ERCC3PROTEIN
UV-induced lesions	Cyclobutane pyrimidine dimers (CPDs), 6-4 photoproducts
Chemical adducts	Benzo[a]pyrene diol epoxide (BPDE) adducts
Oxidative damage	Certain oxidized bases
Crosslinks	DNA interstrand crosslinks
Associated Diseases	Als, Carcinoma, Cirrhosis
Interactions	AKT, CCL2, CEBPB, CHKA, CYP1A2, CYP3A4
KG Connections	42 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ercc3-protein

protein · 1454 words

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Pathway Diagram

graph TD
    ERCC3PROTEIN["ERCC3PROTEIN"]
    neurodegeneration["neurodegeneration"]
    ERCC3PROTEIN -->|"implicated_in"| neurodegeneration
    style ERCC3PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ERCC3PROTEIN in their description or question text

No additional research found