concept

CHKA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHKA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

16Connections

1Hypotheses

1Analyses

11Outgoing

5Incoming

0Experiments

1Debates

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💡 Concept Info

Name	CHKA
Key Genes/Proteins	AKT, CEBPB, DNMT1, EGF, EGFR, ERCC3
Related Diseases	Hepatic Steatosis, translational_neuroscience
Related Pathways	PI3K-AKT-mTOR signaling

Pathway Diagram

graph TD
    CHKA[CHKA]
    CHKA -->|suppresses| Hepatic_Steatosis[Hepatic Steatosis]
    CHKA -->|activates| EGF[EGF]
    CHKA -->|activates| EGFR[EGFR]
    CHKA -->|activates| ERCC3[ERCC3]
    CHKA -->|activates| PDK1[PDK1]
    CHKA -->|activates| PI3K[PI3K]
    CHKA -->|activates| SMPD1[SMPD1]
    CHKA -->|participates in| PI3K_AKT_mTOR_signaling[PI3K-AKT-mTOR signaling]
    CHKA -->|expressed in| neurons[neurons]
    CHKA -->|data_in| benchmark_ot_ad_answer_key_CHK[benchmark_ot_ad_answer_key:CHKA]
    DNMT1[DNMT1] -->|downregulates| CHKA
    AKT[AKT] -->|activates| CHKA
    CEBPB[CEBPB] -->|activates| CHKA
    h_5b0ebb1f[h-5b0ebb1f] -->|targets| CHKA
    benchmark_ot_ad_answer_key_CHK -->|data_in| CHKA

Outgoing (11)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:CHKA	data_in	dataset_row	0.00
Hepatic Steatosis	suppresses	disease	0.90
EGFR	activates	gene	0.60
ERCC3	activates	gene	0.60
PDK1	activates	gene	0.60
SMPD1	activates	gene	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
PI3K	activates	gene	0.60
EGF	activates	gene	0.60
neurons	expressed_in	cell_type	0.55
translational_neuroscience	associated_with	disease	0.40

Incoming (5)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:CHKA	data_in	dataset_row	0.00
DNMT1	downregulates	protein	0.90
AKT	activates	gene	0.60
CEBPB	activates	gene	0.60
h-5b0ebb1f	targets	hypothesis	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Choline Kinase Activity as Membrane Integrity Response Indic	0.663	translational-neuroscience	Which metabolic biomarkers can distingui

Mentioning Analyses (1)

Scientific analyses that reference this entity

Which metabolic biomarkers can distinguish therapeutic response from disease pro

translational neuroscience | 2026-04-04 | 10 hypotheses Top: 0.829

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Which metabolic biomarkers can distinguish therapeutic response from disease pro

closed · Rounds: 4 · Score: 0.92 · 2026-04-04

Related Research

Hypotheses and analyses mentioning CHKA in their description or question text

No additional research found