Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FLUOXETINE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | FLUOXETINE |
| Key Genes/Proteins | EGFR, BDNF |
| Related Diseases | NEUROGENESIS, SEROTONIN, CELL DEATH |
Knowledge base pages for this entity
graph TD
FLUOXETINE["FLUOXETINE"]
FLUOXETINE -->|"inhibits"| SMPD1["SMPD1"]
FLUOXETINE -->|"activates"| dural_Tregs["dural Tregs"]
FLUOXETINE -->|"inhibits"| A1_reactive_astrocyte["A1 reactive astrocyte"]
FLUOXETINE -.protects against.-> depressive_like_behavior["depressive-like behavior"]
FLUOXETINE -->|"inhibits"| EGFR["EGFR"]
FLUOXETINE -->|"activates"| NEURONS["NEURONS"]
ENDOTHELIAL_CELLS["ENDOTHELIAL CELLS"] -->|"treats"| FLUOXETINE| Target | Relation | Type | Str |
|---|---|---|---|
| DENTATE GYRUS | treats | brain_region | 0.70 |
| NEUROGENESIS | treats | phenotype | 0.70 |
| EGFR | inhibits | gene | 0.65 |
| NEURONS | activates | cell_type | 0.65 |
| CA3 | associated_with | brain_region | 0.50 |
| EGFR | associated_with | gene | 0.45 |
| CELL DEATH | associated_with | phenotype | 0.45 |
| SEROTONIN | associated_with | phenotype | 0.45 |
| NEURONS | associated_with | cell_type | 0.45 |
| KETAMINE | associated_with | drug | 0.45 |
| BDNF | associated_with | gene | 0.45 |
| SERTRALINE | associated_with | drug | 0.45 |
| ANXIETY | associated_with | disease | 0.45 |
| SMPD1 | associated_with | gene | 0.45 |
| TEMOZOLOMIDE | associated_with | drug | 0.45 |
| NOREPINEPHRINE | associated_with | phenotype | 0.45 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ENDOTHELIAL CELLS | treats | cell_type | 0.65 |
| SEROTONIN | inhibits | phenotype | 0.65 |
| DENTATE GYRUS | associated_with | brain_region | 0.50 |
| NEUROGENESIS | associated_with | phenotype | 0.50 |
| TEMOZOLOMIDE | associated_with | drug | 0.45 |
| ENDOTHELIAL CELLS | associated_with | cell_type | 0.45 |
| EGFR | associated_with | gene | 0.45 |
| CELL DEATH | associated_with | phenotype | 0.45 |
| BDNF | associated_with | gene | 0.45 |
| ANXIETY | associated_with | disease | 0.45 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||