concept

NEUROGENESIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NEUROGENESIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1371Connections

2Hypotheses

2Analyses

50Outgoing

50Incoming

Summary

NEUROGENESIS is a concept in neurodegeneration research. Key relationships include: promotes, co discussed, inhibits. Associated with ALZHEIMER'S, DEPRESSION, NEURODEGENERATION. Connected to 29 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	NEUROGENESIS
Summary	The process of generating new neurons in the adult brain, its regulation, and its impairment in neurodegenerative diseases including Alzheimer's and Parkinson's
Key Genes/Proteins	TREM2, GFAP, VEGF, APP
Related Diseases	major depressive disorder, COGNITIVE DECLINE
Linked Hypotheses	5 hypotheses

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NEUROGENESIS["NEUROGENESIS"]
    NEUROGENESIS -->|"expressed in"| hippocampus["hippocampus"]
    NEUROGENESIS -->|"interacts"| Notch["Notch"]
    NEUROGENESIS -->|"interacts"| Oxidative_Stress["Oxidative Stress"]
    NEUROGENESIS -->|"interacts"| Mitochondrial_Function["Mitochondrial Function"]
    NEUROGENESIS -->|"interacts"| Angiogenesis["Angiogenesis"]
    NEUROGENESIS -->|"interacts"| Apoptosis["Apoptosis"]
    NEUROGENESIS -->|"interacts"| Complement["Complement"]
    NEUROGENESIS -->|"interacts"| Nf__b["Nf-Kappab"]
    FIP200["FIP200"] -->|"regulates"| NEUROGENESIS
    GFAP["GFAP"] -->|"inhibits"| NEUROGENESIS
    curcumin["curcumin"] -->|"activates"| NEUROGENESIS
    BDNF["BDNF"] -->|"activates"| NEUROGENESIS
    BMAL1["BMAL1"] -->|"activates"| NEUROGENESIS
    gut_microbiota["gut microbiota"] -->|"regulates"| NEUROGENESIS

Outgoing (239)

Target	Relation	Type	Str
NEURON	activates	cell_type	0.95
NEURON	associated_with	cell_type	0.95
major depressive disorder	implicated_in	disease	0.70
DENTATE GYRUS	activates	brain_region	0.70
NEURONS	protects_against	cell_type	0.70
COGNITIVE DECLINE	exacerbates	phenotype	0.70
VEGF	regulates	gene	0.70
NEURAL STEM CELLS	activates	cell_type	0.70
NEURON	regulates	cell_type	0.65
CYTOKINES	inhibits	phenotype	0.65
NRF2	causes	gene	0.65
ASTROCYTES	treats	cell_type	0.65
MICROGLIA	treats	cell_type	0.65
INTERNEURONS	produces	cell_type	0.65
AUTOPHAGY	produces	phenotype	0.65
INFLAMMATION	activates	phenotype	0.65
ISCHEMIA	regulates	disease	0.65
IL1B	interacts_with	gene	0.65
EPILEPSY	activates	disease	0.65
STROKE	treats	disease	0.65
MICROGLIA	biomarker_for	cell_type	0.65
MAPK	inhibits	gene	0.65
MAPK	regulates	gene	0.65
MICROGLIAL ACTIVATION	causes	phenotype	0.65
HIPPOCAMPUS	targets	brain_region	0.65
SIRT3	treats	gene	0.65
INTERNEURONS	stabilizes	cell_type	0.60
ALZHEIMER'S DISEASE	depleted_in	disease	0.60
DEPRESSION	participates_in	disease	0.55
SEROTONIN	implicated_in	phenotype	0.55
TRD	associated_with	disease	0.50
SYNAPTIC PLASTICITY	associated_with	process	0.50
TAU	activates	protein	0.50
NEURON	differentiates_to	cell_type	0.50
CORTEX	associated_with	brain_region	0.50
WNT PATHWAY	associated_with	pathway	0.50
FLUOXETINE	associated_with	drug	0.50
CA1	associated_with	brain_region	0.50
CA3	associated_with	brain_region	0.50
HYPOTHALAMUS	associated_with	brain_region	0.50
SPINAL CORD	associated_with	brain_region	0.45
PSILOCYBIN	associated_with	drug	0.45
BERBERINE	associated_with	drug	0.45
METFORMIN	associated_with	drug	0.45
HIPPOCAMPUS	associated_with	brain_region	0.45
STRIATUM	associated_with	brain_region	0.45
EDARAVONE	associated_with	drug	0.45
WNT3A	associated_with	gene	0.45
RAPAMYCIN	associated_with	drug	0.45
SYP	co_discussed	gene	0.40

Incoming (1132)

Source	Relation	Type	Str
HIPPOCAMPUS	regulates	brain_region	0.95
HIPPOCAMPUS	associated_with	brain_region	0.95
TREM2	promotes	gene	0.80
GFAP	inhibits	protein	0.72
DENTATE GYRUS	regulates	brain_region	0.70
APP	protects_against	gene	0.70
HIPPOCAMPUS	treats	brain_region	0.70
FLUOXETINE	treats	drug	0.70
COGNITIVE DECLINE	increases_risk	phenotype	0.70
NEURONS	produces	cell_type	0.70
PARKINSON	inhibits	disease	0.70
HDAC3	regulates	gene	0.65
ALPHA-SYNUCLEIN	treats	protein	0.65
CURCUMIN	protects_against	drug	0.65
EPO	regulates	gene	0.65
SMAD SIGNALING	treats	pathway	0.65
MICROGLIA	stabilizes	cell_type	0.65
NEURODEGENERATION	synergizes_with	phenotype	0.65
COGNITIVE DECLINE	activates	phenotype	0.65
MICROGLIAL ACTIVATION	activates	phenotype	0.65
TAU	interacts_with	protein	0.65
WNT SIGNALING	causes	pathway	0.65
ASTROCYTES	causes	cell_type	0.65
NLRP3	treats	gene	0.65
WNT3A	activates	gene	0.65
SENESCENCE	causes	phenotype	0.65
SENESCENCE	treats	phenotype	0.65
METFORMIN	activates	drug	0.65
AXL	produces	gene	0.65
HIPPOCAMPUS	produces	brain_region	0.65
AUTOPHAGY	treats	phenotype	0.65
TH	regulates	gene	0.65
AXL	protects_against	gene	0.65
AXL	activates	gene	0.65
STROKE	causes	disease	0.65
SIRT3	interacts_with	gene	0.65
BDNF	activates	protein	0.64
ASTROCYTES	inhibits	cell_type	0.64
BDNF	implicated_in	gene	0.60
APP	targets	gene	0.60
LRRK2	implicated_in	gene	0.55
NEURONS	implicated_in	cell_type	0.55
WNT SIGNALING	implicated_in	pathway	0.55
EPILEPSY	implicated_in	disease	0.55
WNT SIGNALING	participates_in	pathway	0.55
NEURONS	participates_in	cell_type	0.55
AUTOPHAGY	implicated_in	phenotype	0.55
AXL	expressed_in	gene	0.55
DOPAMINE	implicated_in	phenotype	0.55
CELL CYCLE	regulates	process	0.50

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna	0.677	Alzheimer's disease	Circuit-level neural dynamics in neurode
Hypocretin-Neurogenesis Coupling Therapy	0.452	neurodegeneration	Sleep disruption as cause and consequenc

Mentioning Analyses (2)

Scientific analyses that reference this entity

How does SYNGAP1, a 'synaptic' protein, function in pre-synaptic radial glia cel

neurodevelopment | 2026-04-15 | 1 hypotheses Top: 0.576

How do P/Q channel deficits paradoxically increase thalamic excitability despite

synaptic biology | 2026-04-14 | 1 hypotheses Top: 0.526

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
EMI1 switches from being a substrate to an inhibitor of APC/C(CDH1) to start the [PMID:29875408]	Cappell SD, Mark KG, Garbett D, Pack LR,	Nature	2018	1
Metabolic fate of glucose and candidate signaling and excess-fuel detoxification [PMID:28280244]	Mugabo Y, Zhao S, Lamontagne J, Al-Mass	J Biol Chem	2017	1
Sleep drives metabolite clearance from the adult brain. [PMID:24136970]	Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Th	Science	2013	1
Exposure to 1800 MHz radiofrequency radiation induces oxidative damage to mitoch [PMID:19879861]	Xu S, Zhou Z, Zhang L, Yu Z, Zhang W, Wa	Brain Res	2010	1
Nucleotide signaling and cutaneous mechanisms of pain transduction. [PMID:19171165]	Dussor G, Koerber HR, Oaklander AL, Rice	Brain Res Rev	2009	1
Antidepressant effects of combined eucommia-gastrodia extract via modulation of [PMID:41921863]	Xue L, Pan Z, Liu Y, Gan Q, Liu D, Liu D	Brain research bulletin	2026	0
Complementary mechanisms of high-carbohydrate diets and ketogenic diets restore [PMID:41475465]	Kwon H, Seo DS, Ahmad Y, Park S, Yoo J,	The Journal of nutritional bio	2026	0
TrkB promotes the neuronal secretion of soluble Siglec-2 (CD22) to mitigate micr [PMID:41922794]	Shi X, Cai SZ, Chai JL, Xu CY, Zhou BY,	Molecular psychiatry	2026	0
The Potential Functions and Beneficial Effects of Melatonin on Cognitive Impairm [PMID:41917799]	Li XY, Cheng YZ, Zhang YM, Hu F, Fang SK	Brain and behavior	2026	0
Biomarkers for Alzheimer's disease across diverse biological domains: an umbrell [PMID:40680830]	Kang J, Son Y, Yim Y, Cho H, Kim J et al	J Adv Res	2026	0
Nanotherapeutic potential of Baicalein-encapsulated hUC-MSC exosomes in Alzheime [PMID:41370943]	Xu J, He Z, Pan Y, Cao B, Chen G	Biomater Adv	2026	0
Zhi-Gan Formula improved insomnia and anxiety comorbidity in a mouse model via P [PMID:41525914]	Liu R, Wu Z, Yin Y, Song C, Zhang C et a	J Ethnopharmacol	2026	0
Triterpenoid saponins from Platycodon grandiflorus exhibit antidepressant-like e [PMID:41539634]	Yoon S, Chun E, Iqbal H, Kim SH, Kim SY	J Ethnopharmacol	2026	0
Epigenetic mechanisms and therapeutic innovations in chronic pain-associated neu [PMID:41554641]	Zhang K, Zhu S, Xing N, Zhou Z, Chen J e	Br J Pharmacol	2026	0
Postbiotics and the gut-brain axis: A mechanistic review on modulating neuroinfl [PMID:41570486]	Lahariya R, Anand G, Kumari B, Priyadars	J Neuroimmunol	2026	0
miRNA-206 in muscle and central nervous system crosstalk during exercise: A doub [PMID:41571168]	Malvandi AM, Gerosa L, Maroni P, Orlando	Neurosci Biobehav Rev	2026	0
Experts' narrative review "Mastication, Hippocampal Structure Changes and Cognit [PMID:41576846]	Piancino MG	Arch Oral Biol	2026	0
Plant-derived bioactive compounds modulate the gut microbiota in Alzheimer's dis [PMID:41678917]	Xue D, Hu X, Li R, Sun T, Qian S et al.	Phytomedicine	2026	0
Dysregulation of Drp1 and Mfn2 is associated with reduced PSD-95, synaptophysin, [PMID:41932483]	Alfateh M, Vasconcelos C, Choker AH, Moh	Int J Biol Macromol	2026	0
AICAR improves depression-like behaviors and is associated with hippocampal AMPK [PMID:41932583]	Takahashi K, Kurokawa K, Kawaguchi R, Ta	Neurochem Int	2026	0

NEUROGENESIS

Understanding Entity Pages

Summary

Wiki Pages (21)

Neurogenesis

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Corticobasal Syndrome (CBS)

CBS/PSP Supplements Guide

Device Therapies Comparison for CBS/PSP

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Corticobasal Degeneration (CBD)

Neuroresilience Mechanisms and Evidence

Therapeutics

NPM1 Gene

CBS/PSP Treatment Rankings

Alzheimer's Disease

nct07165106

PD Cure Roadmap

Microglial Cells — Cell Type Hierarchy

NTF4 Protein

GSK-3β in Neurodegeneration

Growth Factor Therapies

Circadian Rhythm in Neurodegeneration

Autophagy Mechanisms