concept

NEUROGENESIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NEUROGENESIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1303Connections

3Hypotheses

1Analyses

50Outgoing

50Incoming

13Experiments

1Debates

Summary

NEUROGENESIS is a concept in neurodegeneration research. Key relationships include: promotes, co discussed, inhibits. Associated with ALZHEIMER'S, DEPRESSION, NEURODEGENERATION. Connected to 29 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	NEUROGENESIS
Key Genes/Proteins	ALPHA-SYNUCLEIN, AMYLOID, AMYLOID-BETA, APOE, APP, AQP4
Related Diseases	ALZHEIMER, ALZHEIMER'S DISEASE

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Neurogenesis

cell · 3757 words

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Pathway Diagram

graph TD
    NEUROGENESIS["NEUROGENESIS"]
    NEUROGENESIS -->|"expressed in"| hippocampus["hippocampus"]
    NEUROGENESIS -->|"interacts"| Notch["Notch"]
    NEUROGENESIS -->|"interacts"| Oxidative_Stress["Oxidative Stress"]
    NEUROGENESIS -->|"interacts"| Mitochondrial_Function["Mitochondrial Function"]
    NEUROGENESIS -->|"interacts"| Angiogenesis["Angiogenesis"]
    NEUROGENESIS -->|"interacts"| Apoptosis["Apoptosis"]
    NEUROGENESIS -->|"interacts"| Complement["Complement"]
    NEUROGENESIS -->|"interacts"| Nf__b["Nf-Kappab"]
    FIP200["FIP200"] -->|"regulates"| NEUROGENESIS
    GFAP["GFAP"] -->|"inhibits"| NEUROGENESIS
    curcumin["curcumin"] -->|"activates"| NEUROGENESIS
    BDNF["BDNF"] -->|"activates"| NEUROGENESIS
    BMAL1["BMAL1"] -->|"activates"| NEUROGENESIS
    gut_microbiota["gut microbiota"] -->|"regulates"| NEUROGENESIS

Outgoing (234)

Target	Relation	Type	Str
NEURON	activates	cell_type	0.95
NEURON	associated_with	cell_type	0.95
Post-Traumatic Brain Injury	involved_in	disease	0.88
Alzheimer's Disease	involved_in	disease	0.70
COGNITIVE DECLINE	exacerbates	phenotype	0.70
NEURONS	protects_against	cell_type	0.70
NEURAL STEM CELLS	activates	cell_type	0.70
DENTATE GYRUS	activates	brain_region	0.70
major depressive disorder	implicated_in	disease	0.70
Major Depressive Disorder	associated_with	disease	0.70
VEGF	regulates	gene	0.70
hippocampus	expressed_in	brain_region	0.70
IL1B	interacts_with	gene	0.65
STROKE	treats	disease	0.65
EPILEPSY	activates	disease	0.65
SIRT3	treats	gene	0.65
ISCHEMIA	regulates	disease	0.65
MICROGLIA	biomarker_for	cell_type	0.65
MAPK	regulates	gene	0.65
ASTROCYTES	treats	cell_type	0.65
AUTOPHAGY	produces	phenotype	0.65
MAPK	inhibits	gene	0.65
MICROGLIAL ACTIVATION	causes	phenotype	0.65
NRF2	causes	gene	0.65
MICROGLIA	treats	cell_type	0.65
CYTOKINES	inhibits	phenotype	0.65
INTERNEURONS	produces	cell_type	0.65
HIPPOCAMPUS	targets	brain_region	0.65
NEURON	regulates	cell_type	0.65
INFLAMMATION	activates	phenotype	0.65
SNCA	associated_with	gene	0.60
SYNGAP1	binds_to	gene	0.60
SYNCRIP	binds_to	gene	0.60
PARK7	associated_with	gene	0.60
TRKB	activates	gene	0.60
NPY	activates	gene	0.60
ALZHEIMER'S DISEASE	depleted_in	disease	0.60
neuroinflammation	regulates	process	0.60
PP2A	associated_with	gene	0.60
synaptic plasticity	inhibits	process	0.60
SOX2	associated_with	gene	0.60
INTERNEURONS	stabilizes	cell_type	0.60
oxidative stress	associated_with	process	0.60
oxidative stress	activates	process	0.60
RNA	binds_to	gene	0.60
TRKB	co_mentioned	gene	0.55
Pi3K	interacts_with	pathway	0.55
Akt	interacts_with	pathway	0.55
Synaptic Plasticity	interacts_with	pathway	0.55
Nf-Κb	interacts_with	pathway	0.55

Incoming (1069)

Source	Relation	Type	Str
Inflammation	activates	disease	1.00
BDNF	activates	gene	1.00
Als	activates	disease	1.00
Neurodegeneration	activates	disease	1.00
APOPTOSIS	activates	gene	1.00
OXIDATIVE STRESS	activates	gene	1.00
BDNF	activates	protein	1.00
NEURODEGENERATION	activates	gene	1.00
DEPRESSION	activates	gene	1.00
INFLAMMATION	activates	gene	1.00
Neuroinflammation	activates	disease	1.00
CYTOKINES	activates	gene	1.00
Depression	activates	disease	1.00
WNT	regulates	pathway	0.95
HIPPOCAMPUS	associated_with	brain_region	0.95
HIPPOCAMPUS	regulates	brain_region	0.95
NPY	promotes	protein	0.95
Exercise Training	promotes	process	0.92
AdipoRon	associated_with	drug	0.90
Notch Signaling	inhibits	pathway	0.90
FIP200	regulates	protein	0.90
Adult Neural Stem Cells	involved_in	cell_type	0.90
24797482	enhance	paper	0.90
31606043	suppressed	paper	0.90
BDNF	promotes	protein	0.90
Exercise	upregulates	process	0.90
Tumor	activates	disease	0.90
TNF	activates	gene	0.90
NEUROINFLAMMATION	activates	gene	0.90
Als	associated_with	disease	0.90
NEURODEGENERATION	associated_with	gene	0.90
Neurodegeneration	associated_with	disease	0.90
Aging	activates	disease	0.90
Itaconate	promotes	compound	0.88
SOX2	associated_with	gene	0.88
PI3K/AKT	regulates	pathway	0.85
USP9X	promotes	gene	0.85
Apbb1Ip	biomarker_for	biomarker	0.85
HDAC3	modulates	gene	0.85
Alzheimer's Disease	inhibits	disease	0.85
PI3K/AKT pathway	regulates	pathway	0.85
SIRT1	regulates	protein	0.85
Oxytocin	associated_with	drug	0.85
Α-SYNUCLEIN	inhibits	protein	0.85
Aβ42	modulates	biomarker	0.85
Microglia Activation	regulates	process	0.85
METALLOTHIONEIN-I+II	associated_with	protein	0.85
MT2	involved_in	protein	0.85
MT1	involved_in	protein	0.85
USP9X	involved_in	gene	0.85

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna	0.820	alzheimers	Circuit-level neural dynamics in neurode
Hypocretin-Neurogenesis Coupling Therapy	0.688	neurodegeneration	Sleep disruption as cause and consequenc
HBOT at 2.0 ATA for 60 min, 5x/week for 6 weeks enhances hip	0.450	neurodegeneration	What are the optimal oxygen pressure, du

Mentioning Analyses (1)

Scientific analyses that reference this entity

Neuroinflammation Biomarker Panel for Early AD Detection

neurodegeneration | 2026-04-18 | 7 hypotheses Top: 0.105

Experiments (13)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Spp1 knockout prevents synaptic loss in AD mouse models	validation	Alzheimer's disease	0.900	0.00	Spp1 knockout AD mouse models	proposed	N/A
Synaptic plasticity and protein expression analysis in mPFC	exploratory	insomnia-anxiety comorbidity	0.850	0.00	mPFC brain slices from PCPA-tr	proposed	N/A
Brain Connectivity-Targeted tACS Trial in Early AD	clinical	Alzheimer's Disease	0.509	0.50	human postmortem brain tissue	proposed	$520,000
s:** - Test whether HCN1 knockout specifically in EC layer II accelera	falsification	Alzheimer's Disease	0.400	0.50	cell_line	proposed	$80,000
AD Amyloid-Resilient Phenotype Study — Why Some amyloid-Positive Indiv	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$6,550,000
AD Combination Therapy Trial: Anti-Aβ + Anti-Tau	clinical	Alzheimer's Disease	0.400	0.50	cell_line	proposed	$180,000
Animal Model Comparison for Neurodegenerative Disease Therapeutics	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$7,100,000
Biomarker-Guided Sequential Therapy Selection in Alzheimer's Disease	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
tACS Connectivity Trial in Early Alzheimer's	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Brain Connectivity-Targeted tACS Trial in Early AD	clinical	Alzheimer's Disease	0.400	0.50	mouse	proposed	$730,000
Brainstem Circuit Modulation for PSP	clinical	ALS	0.400	0.50	human	proposed	$5,460,000
Neural Stem Cell Therapy for Alzheimer's Disease	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Sleep and Respiratory Network Interaction in ALS — Experiment Design	clinical	ALS	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
EMI1 switches from being a substrate to an inhibitor of APC/C(CDH1) to start the [PMID:29875408]	Cappell SD, Mark KG, Garbett D, Pack LR,	Nature	2018	1
Metabolic fate of glucose and candidate signaling and excess-fuel detoxification [PMID:28280244]	Mugabo Y, Zhao S, Lamontagne J, Al-Mass	J Biol Chem	2017	1
Sleep drives metabolite clearance from the adult brain. [PMID:24136970]	Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Th	Science	2013	1
Exposure to 1800 MHz radiofrequency radiation induces oxidative damage to mitoch [PMID:19879861]	Xu S, Zhou Z, Zhang L, Yu Z, Zhang W, Wa	Brain Res	2010	1
Nucleotide signaling and cutaneous mechanisms of pain transduction. [PMID:19171165]	Dussor G, Koerber HR, Oaklander AL, Rice	Brain Res Rev	2009	1
Antidepressant effects of combined eucommia-gastrodia extract via modulation of [PMID:41921863]	Xue L, Pan Z, Liu Y, Gan Q, Liu D, Liu D	Brain research bulletin	2026	0
Complementary mechanisms of high-carbohydrate diets and ketogenic diets restore [PMID:41475465]	Kwon H, Seo DS, Ahmad Y, Park S, Yoo J,	The Journal of nutritional bio	2026	0
TrkB promotes the neuronal secretion of soluble Siglec-2 (CD22) to mitigate micr [PMID:41922794]	Shi X, Cai SZ, Chai JL, Xu CY, Zhou BY,	Molecular psychiatry	2026	0
The Potential Functions and Beneficial Effects of Melatonin on Cognitive Impairm [PMID:41917799]	Li XY, Cheng YZ, Zhang YM, Hu F, Fang SK	Brain and behavior	2026	0
Biomarkers for Alzheimer's disease across diverse biological domains: an umbrell [PMID:40680830]	Kang J, Son Y, Yim Y, Cho H, Kim J et al	J Adv Res	2026	0
Nanotherapeutic potential of Baicalein-encapsulated hUC-MSC exosomes in Alzheime [PMID:41370943]	Xu J, He Z, Pan Y, Cao B, Chen G	Biomater Adv	2026	0
Epigenetic mechanisms and therapeutic innovations in chronic pain-associated neu [PMID:41554641]	Zhang K, Zhu S, Xing N, Zhou Z, Chen J e	Br J Pharmacol	2026	0
Postbiotics and the gut-brain axis: A mechanistic review on modulating neuroinfl [PMID:41570486]	Lahariya R, Anand G, Kumari B, Priyadars	J Neuroimmunol	2026	0
miRNA-206 in muscle and central nervous system crosstalk during exercise: A doub [PMID:41571168]	Malvandi AM, Gerosa L, Maroni P, Orlando	Neurosci Biobehav Rev	2026	0
Experts' narrative review "Mastication, Hippocampal Structure Changes and Cognit [PMID:41576846]	Piancino MG	Arch Oral Biol	2026	0
Plant-derived bioactive compounds modulate the gut microbiota in Alzheimer's dis [PMID:41678917]	Xue D, Hu X, Li R, Sun T, Qian S et al.	Phytomedicine	2026	0
Dysregulation of Drp1 and Mfn2 is associated with reduced PSD-95, synaptophysin, [PMID:41932483]	Alfateh M, Vasconcelos C, Choker AH, Moh	Int J Biol Macromol	2026	0
AICAR improves depression-like behaviors and is associated with hippocampal AMPK [PMID:41932583]	Takahashi K, Kurokawa K, Kawaguchi R, Ta	Neurochem Int	2026	0
Human umbilical cord mesenchymal stem cells therapy for Alzheimer's disease: a s [PMID:41847685]	Si C, Ma L, Ding W, Tian Y, Zhang J, Cao	Frontiers in neurology	2026	0
Cannabidiol and pBDNF Cotreatment Attenuates Pathological Symptoms and Improves [PMID:41924980]	Chaulagain B, Gothwal A, Mahanta AK, Jar	ACS chemical neuroscience	2026	0

Debates (1)

Multi-agent debates referencing this entity

What is the optimal blood-based biomarker panel combining established markers (G

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

Related Research

Hypotheses and analyses mentioning NEUROGENESIS in their description or question text

No additional research found