concept

KETAMINE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KETAMINE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

86Connections

0Hypotheses

0Analyses

20Outgoing

17Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	KETAMINE
Key Genes/Proteins	BDNF, CSF1R
Related Diseases	DEPRESSION, ANXIETY, GLUTAMATE

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    KETAMINE["KETAMINE"]
    KETAMINE -->|"treats"| Depression["Depression"]
    KETAMINE -->|"treats"| rapid_antidepressant_response["rapid antidepressant response"]
    KETAMINE -->|"inhibits"| NMDAR["NMDAR"]
    KETAMINE -->|"upregulates"| BDNF["BDNF"]
    KETAMINE -->|"activates"| ERK["ERK"]
    KETAMINE -->|"treats"| acute_kidney_injury["acute kidney injury"]
    KETAMINE -->|"targets"| GABAergic_Interneurons["GABAergic Interneurons"]
    KETAMINE -->|"treats"| Treatment_Resistant_Depression["Treatment-Resistant Depression"]
    BDNF -->|"mediates"| KETAMINE
    CSF1R["CSF1R"] -->|"inhibits"| KETAMINE

Outgoing (68)

Target	Relation	Type	Str
BDNF	activates	protein	0.68
DEPRESSION	activates	disease	0.65
ANXIETY	interacts_with	disease	0.65
ANXIETY	targets	disease	0.65
GLUTAMATE	activates	phenotype	0.65
BDNF	interacts_with	gene	0.65
DEPRESSION	causes	disease	0.65
CA1	regulates	brain_region	0.65
BDNF	regulates	gene	0.65
ANTIDEPRESSANT	associated_with	drug	0.64
DEPRESSION	stabilizes	disease	0.60
CA1	expressed_in	brain_region	0.55
CA1	associated_with	brain_region	0.50
BDNF	associated_with	gene	0.45
ANXIETY	associated_with	disease	0.45
CREB	associated_with	gene	0.45
ERK	associated_with	gene	0.45
CSF1R	associated_with	gene	0.45
SYNAPSE	associated_with	phenotype	0.45
MICROGLIA	associated_with	cell_type	0.45

Incoming (18)

Source	Relation	Type	Str
BDNF	inhibits	gene	0.65
CSF1R	inhibits	gene	0.65
BDNF	stabilizes	gene	0.60
DEPRESSION	associated_with	disease	0.45
BIPOLAR DISORDER	associated_with	disease	0.45
MICROGLIA	associated_with	cell_type	0.45
INFLAMMATION	associated_with	phenotype	0.45
HIPPOCAMPUS	associated_with	brain_region	0.45
GLUTAMATE	associated_with	phenotype	0.45
FLUOXETINE	associated_with	drug	0.45
BDNF	associated_with	gene	0.45
ANXIETY	associated_with	disease	0.45
CREB	associated_with	gene	0.45
ERK	associated_with	gene	0.45
CSF1R	associated_with	gene	0.45
BLOOD-BRAIN BARRIER	associated_with	phenotype	0.45
BBB	associated_with	phenotype	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

KETAMINE

Understanding Entity Pages

Wiki Pages (20)

Spinal Cord Dorsal Horn Neurons

Excitotoxicity in Neurodegeneration

Neurogenesis

Excitotoxicity Pathway

CNTFR Gene

Mesolimbic Dopamine Pathway

Hypothalamic-Pituitary-Adrenal Axis

erk-mapk-signaling-neurodegeneration

GRIN1 — NMDA Receptor Subunit 1

GRIN2D Protein

Brain & Behavior Research Foundation

NTRK2 Gene

Adult Hippocampal Neurogenesis: Impaired in Alzheimer's Disease, Enhanced in Superagers

Alzheimer's Disease GABA Receptor and Excitotoxicity Therapy Companies

Brain-Derived Neurotrophic Factor (BDNF)

Glutamate Excitotoxicity in Neurodegeneration

grin1-protein

Synaptic Protection Therapies