Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FLOTILLIN-1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | FLOTILLIN |
| Chromosome | 6p21.3. |
| Function | regulating membrane organization |
| Molecular Weight | 47 kDa |
| Amino Acids | 427 aa |
| Pathways | Invasion |
| GeneCards | FLOTILLIN |
| Human Protein Atlas | FLOTILLIN |
| Interactions | GLIOBLASTOMA, BETA-AMYLOID, AMYLOID, FLOT1 |
| KG Connections | 7 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
FLOTILLIN_1(["FLOTILLIN-1"])
cancer["cancer"]
GLIOBLASTOMA(["GLIOBLASTOMA"])
Invasion["Invasion"]
ENDOSOMES("ENDOSOMES")
BETA_AMYLOID(["BETA-AMYLOID"])
AMYLOID(["AMYLOID"])
FLOT1(["FLOT1"])
FLOTILLIN_1 -->|"activates"| cancer
FLOTILLIN_1 -->|"activates"| GLIOBLASTOMA
FLOTILLIN_1 -->|"activates"| Invasion
FLOTILLIN_1 -->|"activates"| ENDOSOMES
FLOTILLIN_1 -->|"interacts with"| BETA_AMYLOID
FLOTILLIN_1 -->|"interacts with"| AMYLOID
FLOT1 -->|"activates"| FLOTILLIN_1
style FLOTILLIN_1 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff| Target | Relation | Type | Str |
|---|---|---|---|
| cancer | activates | disease | 0.50 |
| GLIOBLASTOMA | activates | gene | 0.50 |
| Invasion | activates | pathway | 0.50 |
| ENDOSOMES | activates | concept | 0.50 |
| BETA-AMYLOID | interacts_with | protein | 0.50 |
| AMYLOID | interacts_with | gene | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| FLOT1 | activates | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Flotillin-1 Stabilization Compounds | 0.422 | neurodegeneration | Lipid raft composition changes in synapt |
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Endosomal-Lysosomal and Autophagy Pathway in Alzheimer's Disease: A Systematic R [PMID:35754279] | Saffire H Krance, Che-Yuan Wu, Alison C | Journal of Alzheimer's disease | 2022 | 1 |
| Membrane remodeling and higher-order structure formation by DivIVA. [PMID:41819316] | Labajová N, Obořilová R, Pinkas D, Přiby | Int J Biol Macromol | 2026 | 0 |
| Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746] | ["Sanadgol N", "Abedi M", "Hashemzaei M" | Journal of nanobiotechnology | 2025 | 0 |
| Flotillin-1 palmitoylation is essential for its stability and subsequent tumor p [PMID:38374406] | McClellan B, Wilson CN, Brenner AJ, Joll | Oncogene | 2024 | 0 |
| FLOT1 promotes gastric cancer progression and metastasis through BCAR1/ERK signa [PMID:37928269] | Wang R, Huang W, Cai K, Xiao S, Zhang W, | International journal of biolo | 2023 | 0 |
| SDC1-TGM2-FLOT1-BHMT complex determines radiosensitivity of glioblastoma by infl [PMID:37441590] | ["Zeng L", "Zheng W", "Liu X", "Zhou Y", | Theranostics | 2023 | 0 |
| The roles of FLOT1 in human diseases (Review). [PMID:37772385] | Zhan Z, Ye M, Jin X | Molecular medicine reports | 2023 | 0 |
| Perindopril ameliorates experimental Alzheimer's disease progression: role of am [PMID:32488543] | Messiha BAS, Ali MRA, Khattab MM, Abo-Yo | Inflammopharmacology | 2020 | 0 |
| Flotillin membrane domains in cancer. [PMID:32297092] | ["Gauthier-Rouvi\u00e8re C", "Bodin S", | Cancer metastasis reviews | 2020 | 0 |
| Prognostic value of flotillins (flotillin-1 and flotillin-2) in human cancers: A [PMID:29499201] | ["Deng Y", "Ge P", "Tian T", "Dai C", "W | Clinica chimica acta; internat | 2018 | 0 |
| Glutaminase 1 regulates the release of extracellular vesicles during neuroinflam [PMID:29540215] | ["Wu B", "Liu J", "Zhao R", "Li Y", "Pee | Journal of neuroinflammation | 2018 | 0 |
| Cellular uptake of extracellular vesicles is mediated by clathrin-independent en [PMID:28919558] | Costa Verdera H, Gitz-Francois JJ, Schif | Journal of controlled release | 2017 | 0 |
| Elevated LRRK2 autophosphorylation in brain-derived and peripheral exosomes in L [PMID:29166931] | Wang S, Liu Z, Ye T, Mabrouk OS, Maltbie | Acta neuropathologica communic | 2017 | 0 |
| A role for lipid rafts in the protection afforded by docosahexaenoic acid agains [PMID:23907024] | ["Aliche-Djoudi F", "Podechard N", "Coll | Food and chemical toxicology : | 2013 | 0 |
| The chemokine, macrophage inflammatory protein-2γ, reduces the expression of glu [PMID:23234294] | ["Fang J", "Han D", "Hong J", "Tan Q", " | Journal of neuroinflammation | 2012 | 0 |
| Intoxication of zebrafish and mammalian cells by cholera toxin depends on the fl [PMID:21041954] | ["Saslowsky D", "Cho J", "Chinnapen H", | The Journal of clinical invest | 2010 | 0 |
| Flotillin-1 stabilizes caveolin-1 in intestinal epithelial cells. [PMID:19121286] | ["Vassilieva E", "Ivanov A", "Nusrat A"] | Biochemical and biophysical re | 2009 | 0 |