protein

BETA-AMYLOID

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BETA-AMYLOID: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

81Connections

0Hypotheses

1Analyses

50Outgoing

15Incoming

Summary

Beta-amyloid Peptide

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🔬 Protein Info

Gene Symbol	BETA-AMYLOID
Amino Acids	43 aa
Pathways	Neuroinflammatory, Cholesterol
GeneCards	BETA-AMYLOID
Human Protein Atlas	BETA-AMYLOID
Species	Length
Aβ1-38	38 aa
Aβ1-40	40 aa
Aβ1-42	42 aa
Aβ1-43	43 aa
Approach	Example
Active vaccination	AN1792 (failed), ACI-35
Monoclonal antibodies	Aducanumab, Lecanemab, Donanemab
Antibody fragments	Nanobodies
Target	Strategy
Associated Diseases	Alzheimer Disease, Alzheimer'S Disease, disease, oxidative stress
Interactions	ALZHEIMER, AMYLOID, Proteins, PHOSPHORYLATED TAU, GFAP, IBA1
KG Connections	69 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    BETA_AMYLOID["<b>BETA-AMYLOID</b>"]
    Alzheimer_Disease["Alzheimer Disease"]
    BETA_AMYLOID -->|"biomarker for"| Alzheimer_Disease
    Neuritic_Plaques["Neuritic Plaques"]
    BETA_AMYLOID -->|"component of"| Neuritic_Plaques
    Cerebral_Amyloid_Angiopathy["Cerebral Amyloid Angiopathy"]
    BETA_AMYLOID -->|"involved in"| Cerebral_Amyloid_Angiopathy
    ALZHEIMER["ALZHEIMER"]
    BETA_AMYLOID -->|"activates"| ALZHEIMER
    Alzheimer_S_Disease["Alzheimer'S Disease"]
    BETA_AMYLOID -->|"activates"| Alzheimer_S_Disease
    AMYLOID["AMYLOID"]
    BETA_AMYLOID -->|"activates"| AMYLOID
    disease["disease"]
    BETA_AMYLOID -->|"activates"| disease
    ALZHEIMER_S["ALZHEIMER'S"]
    BETA_AMYLOID -->|"activates"| ALZHEIMER_S
    AMYLOID["AMYLOID"]
    BETA_AMYLOID -->|"associated with"| AMYLOID
    Neuroinflammatory["Neuroinflammatory"]
    BETA_AMYLOID -->|"associated with"| Neuroinflammatory
    NEURONS["NEURONS"]
    BETA_AMYLOID -->|"activates"| NEURONS
    CELL_DEATH["CELL DEATH"]
    BETA_AMYLOID -->|"activates"| CELL_DEATH
    apoptosis["apoptosis"]
    BETA_AMYLOID -->|"associated with"| apoptosis
    AMYLOID["AMYLOID"]
    BETA_AMYLOID -->|"interacts with"| AMYLOID
    disease["disease"]
    BETA_AMYLOID -->|"associated with"| disease
    ORGANOIDS["ORGANOIDS"]
    BETA_AMYLOID -->|"associated with"| ORGANOIDS
    ALZHEIMER["ALZHEIMER"]
    BETA_AMYLOID -->|"associated with"| ALZHEIMER
    Alzheimer_Disease["Alzheimer Disease"]
    BETA_AMYLOID -->|"associated with"| Alzheimer_Disease
    Genes["Genes"]
    BETA_AMYLOID -->|"associated with"| Genes
    Cortex["Cortex"]
    BETA_AMYLOID -->|"associated with"| Cortex
    AMYLOID["AMYLOID"]
    BETA_AMYLOID -->|"inhibits"| AMYLOID
    Hippocampus["Hippocampus"]
    BETA_AMYLOID -->|"inhibits"| Hippocampus
    oxidative_stress["oxidative stress"]
    BETA_AMYLOID -->|"associated with"| oxidative_stress
    Alzheimer_S_Disease["Alzheimer'S Disease"]
    BETA_AMYLOID -->|"associated with"| Alzheimer_S_Disease
    BLOOD_BRAIN_BARRIER["BLOOD-BRAIN BARRIER"]
    BETA_AMYLOID -->|"associated with"| BLOOD_BRAIN_BARRIER
    ALZHEIMER_S["ALZHEIMER'S"]
    BETA_AMYLOID -->|"associated with"| ALZHEIMER_S
    ENDOTHELIAL["ENDOTHELIAL"]
    BETA_AMYLOID -->|"associated with"| ENDOTHELIAL
    ALZHEIMER["ALZHEIMER"]
    BETA_AMYLOID -->|"interacts with"| ALZHEIMER
    Alzheimer_S_Disease["Alzheimer'S Disease"]
    BETA_AMYLOID -->|"interacts with"| Alzheimer_S_Disease
    disease["disease"]
    BETA_AMYLOID -->|"interacts with"| disease

Outgoing (59)

Target	Relation	Type	Str
Alzheimer Disease	biomarker_for	disease	0.95
Neuritic Plaques	component_of	phenotype	0.95
Cerebral Amyloid Angiopathy	involved_in	disease	0.90
Alzheimer's disease	causes	disease	0.80
ALZHEIMER	activates	gene	0.50
Alzheimer'S Disease	activates	disease	0.50
AMYLOID	activates	gene	0.50
disease	activates	disease	0.50
ALZHEIMER'S	activates	concept	0.50
AMYLOID	associated_with	gene	0.50
Neuroinflammatory	associated_with	pathway	0.50
NEURONS	activates	concept	0.50
CELL DEATH	activates	concept	0.50
apoptosis	associated_with	process	0.50
AMYLOID	interacts_with	gene	0.50
disease	associated_with	disease	0.50
ORGANOIDS	associated_with	concept	0.50
ALZHEIMER	associated_with	gene	0.50
Alzheimer Disease	associated_with	disease	0.50
Cortex	associated_with	brain_region	0.50
AMYLOID	inhibits	gene	0.50
Hippocampus	inhibits	entity	0.50
oxidative stress	associated_with	phenotype	0.50
Alzheimer'S Disease	associated_with	disease	0.50
ALZHEIMER'S	associated_with	concept	0.50
ENDOTHELIAL	associated_with	concept	0.50
ALZHEIMER	interacts_with	gene	0.50
Alzheimer'S Disease	interacts_with	disease	0.50
disease	interacts_with	disease	0.50
ALZHEIMER'S	interacts_with	concept	0.50
Cognitive Decline	interacts_with	disease	0.50
ALZHEIMER	causes	gene	0.50
AMYLOID	causes	gene	0.50
Alzheimer Disease	causes	disease	0.50
disease	causes	disease	0.50
DEMENTIA	associated_with	gene	0.50
Cortex	inhibits	brain_region	0.50
aging	activates	phenotype	0.50
Cholesterol	associated_with	pathway	0.50
Cholesterol	inhibits	pathway	0.50
Proteins	inhibits	protein	0.50
Alzheimer Disease	activates	disease	0.50
Hippocampus	activates	entity	0.50
GENE EXPRESSION	activates	concept	0.50
ALZHEIMER	inhibits	gene	0.50
Alzheimer'S Disease	inhibits	disease	0.50
disease	inhibits	disease	0.50
ALZHEIMER'S	inhibits	concept	0.50
WNT SIGNALING	associated_with	concept	0.50
Astrocytes	inhibits	cell_type	0.50

Incoming (22)

Source	Relation	Type	Str
hearing loss	increases	disease	0.80
PHOSPHORYLATED TAU	activates	protein	0.50
PHOSPHORYLATED TAU	associated_with	protein	0.50
AQP4	associated_with	gene	0.50
GFAP	associated_with	gene	0.50
GFAP	interacts_with	gene	0.50
IBA1	interacts_with	protein	0.50
Neuroinflammation	inhibits	process	0.50
IL-6	inhibits	protein	0.50
Neurodegeneration	associated_with	disease	0.50
Neurodegeneration	interacts_with	disease	0.50
FLOTILLIN-1	interacts_with	protein	0.50
BETA-AMYLOID PEPTIDE	causes	protein	0.50
acetylcholine	associated_with	disease	0.50
BETA-AMYLOID PEPTIDE	associated_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does PSEN2 mechanistically regulate α-synuclein expression and pathology in

neurodegeneration | 2026-04-13 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

BETA-AMYLOID

Understanding Entity Pages

Summary

Wiki Pages (21)

Beta-amyloid Peptide

Parkinson's Disease

Sleep and Circadian Dysfunction in Alzheimer's Disease

primary-progressive-aphasia

CBS/PSP Supplements Guide

Corticobasal Degeneration (CBD)

GRIA3 Gene

Tau Spreading Mechanism

amyloid-beta-metalloproteinases

Melatonin for Tauopathy: Comprehensive Evidence Synthesis

Cerebellar Function

Coenzyme Q10 for Neurodegeneration

Pre-symptomatic Conversion Windows in ALS Genetic Risk Carriers

Copper Dyshomeostasis in Neurodegeneration

PMN310 Anti-Amyloid for AD (NCT06750432)

Cerebrospinal Fluid (CSF) Biomarkers Overview

creatine-supplementation-neurodegeneration

Benfotiamine Phase 2 Alzheimer's Disease Trial (NCT06223360)

Autophagy-Lysosomal Impairment Across Neurodegenerative Diseases

Amyloid-Beta Aggregation and Plaque Formation