gene

FLOT1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FLOT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

306Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

Page for FLOT1 Gene

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🧬 Gene Info

Gene Symbol	FLOT1
Full Name	Flotillin 1
Chromosome	6p21.3
Protein Type	Structural Protein
Target Class	Structural Protein
Function	FLOT1 performs essential cellular functions
Mechanism of Action	Drug candidates would modulate FLOT1-mediated lipid raft organization and signaling platform assembly, thereby disrupting pathological protein trafficking and reducing amyloid-beta or tau-related pathology in neurodegenerative diseases. FLOT1 inhibitors would interfere with membrane scaffold formation necessary for aberrant signaling in neuroinflammatory and proteinopathic cascades.
Primary Expression	activated microglia)
Druggability	Low (0.35)
Clinical Stage	Phase II
Molecular Weight	47 kDa
Amino Acids	427 aa
Pathways	Mitochondrial Function, cholesterol secretion, endocytosis, epithelial-mesenchymal transition, glioblastoma cell invasion
UniProt ID	O75955
NCBI Gene ID	10211
Ensembl ID	ENSG00000231768
OMIM	606823
GeneCards	FLOT1
Human Protein Atlas	FLOT1
Associated Diseases	ALS, Alzheimer'S Disease, CANCER
Known Drugs/Compounds	Methyl-beta-cyclodextrin, Filipin III, Dynasore, FLT1-targeting antisense oligonucleotide (investigational)
Interactions	P38, TAU, Rb, GBM, TNF, SDC1
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	Flotillin-1 Stabilization Compounds
KG Connections	306 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: FLOT1 — AlphaFold A0A0G2JJQ6 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (17)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    FLOT1["<b>FLOT1</b>"]
    neurodegeneration["neurodegeneration"]
    FLOT1 -->|"studied in"| neurodegeneration
    FLOT1 -->|"implicated in"| neurodegeneration
    FLOT1 -->|"associated with"| neurodegeneration
    lipid_raft_scaffolding["lipid_raft_scaffolding"]
    FLOT1 -->|"associated with"| lipid_raft_scaffolding
    h_a015e80e["h-a015e80e"]
    h_a015e80e -->|"therapeutic target"| FLOT1
    h_a015e80e -->|"targets"| FLOT1
    style FLOT1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (249)

Target	Relation	Type	Str
EPHA2	regulates	gene	0.95
Lipid Raft Formation	involved_in	process	0.95
Endocytosis	involved_in	process	0.95
Cancer	associated_with	disease	0.95
Hippocampal Synapse Formation	involved_in	process	0.90
Cancer Cell Proliferation	modulates	phenotype	0.90
Major Depressive Disorder	associated_with	disease	0.90
Neuroinflammation	modulates	process	0.90
Microglia	modulates	cell_type	0.90
Epithelial-Mesenchymal Transition	modulates	process	0.90
Alzheimer'S Disease	associated_with	disease	0.90
Parkinson'S Disease	associated_with	disease	0.90
Spatial Memory	modulates	phenotype	0.85
Dilated Cardiomyopathy	associated_with	disease	0.85
Diabetes-Related Diseases	associated_with	disease	0.85
Pathogenic Microbial Infection	associated_with	disease	0.80
Alzheimer	expressed_in	disease	0.65
Cancer	activates	disease	0.65
Diabetes	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Parkinson	expressed_in	disease	0.65
Glioblastoma	expressed_in	disease	0.65
Als	causes	disease	0.65
Als	regulates	disease	0.65
Aging	regulates	disease	0.65
Schizophrenia	regulates	disease	0.65
Alzheimer	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
ALS	expressed_in	disease	0.65
ALS	causes	disease	0.65
ALS	regulates	disease	0.65
Bipolar	regulates	disease	0.65
Inflammation	activates	disease	0.65
Cardiomyopathy	expressed_in	disease	0.65
Aging	expressed_in	disease	0.65
Schizophrenia	expressed_in	disease	0.65
Bipolar	expressed_in	disease	0.65
neurodegeneration	implicated_in	disease	0.60
endocytosis	involved_in	pathway	0.60
hippocampal synapses	involved_in	pathway	0.60
cancer	associated_with	disease	0.60
epithelial-mesenchymal transition	regulates	pathway	0.60
major depressive disorder	associated_with	disease	0.60
cholesterol secretion	involved_in	pathway	0.60
glioblastoma cell proliferation	regulates	pathway	0.60
glioblastoma cell invasion	regulates	pathway	0.60
glioblastoma cell migration	regulates	pathway	0.60
SLC12A5	causes	gene	0.60
GBM	expressed_in	gene	0.60
Opc	causes	cell_type	0.60

Incoming (57)

Source	Relation	Type	Str
h-a015e80e	targets_gene	hypothesis	0.90
Long Intergenic Non-Coding Rna	regulates	biomarker	0.85
h-a015e80e	targets	hypothesis	0.80
GBM	expressed_in	gene	0.60
SLC12A5	causes	gene	0.60
TAU	activates	gene	0.60
APP	inhibits	gene	0.60
APP	protects_against	gene	0.60
APP	biomarker_for	gene	0.60
endocytosis	associated_with	process	0.60
ALZHEIMER	expressed_in	gene	0.60
COP1	causes	gene	0.60
ASTROCYTES	causes	gene	0.60
AMYLOID-BETA	activates	gene	0.60
APP/PS1	inhibits	gene	0.60
PARKINSON	expressed_in	gene	0.60
GENES	associated_with	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
FOSL2	activates	gene	0.60
CYTOKINES	activates	gene	0.60
MAPK	activates	gene	0.60
MICRORNAS	regulates	gene	0.60
MICROGLIA	causes	gene	0.60
CANCER	inhibits	disease	0.60
ALZHEIMER	causes	disease	0.60
ALZHEIMER'S	causes	disease	0.60
ALZHEIMER'S DISEASE	causes	disease	0.60
CANCER	regulates	disease	0.60
CANCER	promotes	disease	0.60
COP1	associated_with	gene	0.60
C1Q	activates	gene	0.55
EPHA2	activates	gene	0.50
EPHA2	interacts_with	gene	0.50
ALZHEIMER	activates	gene	0.50
AMYLOID	activates	gene	0.50
CHIP	activates	protein	0.50
GENES	inhibits	gene	0.50
Neuroinflammation	activates	process	0.50
microglia	activates	cell_type	0.50
ABCA1	debate_co_mention	gene	0.45
BACE1	debate_co_mention	gene	0.45
CYP46A1	debate_co_mention	gene	0.45
ABCA1/LDLR/SREBF2	debate_co_mention	gene	0.45
ST8SIA1	co_discussed	gene	0.40
LDLR	co_discussed	gene	0.40
BACE1	co_discussed	gene	0.40
CYP46A1	co_discussed	gene	0.40
ST3GAL2	co_discussed	gene	0.40
SGMS1	co_discussed	gene	0.40
Flotillin-1	references	protein	0.40

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Flotillin-1 Stabilization Compounds	0.422	neurodegeneration	Lipid raft composition changes in synapt

Mentioning Analyses (1)

Scientific analyses that reference this entity

Lipid raft composition changes in synaptic neurodegeneration

neurodegeneration | 2026-04-01 | 12 hypotheses Top: 0.648

Related Papers (17)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Endosomal-Lysosomal and Autophagy Pathway in Alzheimer's Disease: A Systematic R [PMID:35754279]	Saffire H Krance, Che-Yuan Wu, Alison C	Journal of Alzheimer's disease	2022	1
Membrane remodeling and higher-order structure formation by DivIVA. [PMID:41819316]	Labajová N, Obořilová R, Pinkas D, Přiby	Int J Biol Macromol	2026	0
Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746]	["Sanadgol N", "Abedi M", "Hashemzaei M"	Journal of nanobiotechnology	2025	0
Flotillin-1 palmitoylation is essential for its stability and subsequent tumor p [PMID:38374406]	McClellan B, Wilson CN, Brenner AJ, Joll	Oncogene	2024	0
FLOT1 promotes gastric cancer progression and metastasis through BCAR1/ERK signa [PMID:37928269]	Wang R, Huang W, Cai K, Xiao S, Zhang W,	International journal of biolo	2023	0
SDC1-TGM2-FLOT1-BHMT complex determines radiosensitivity of glioblastoma by infl [PMID:37441590]	["Zeng L", "Zheng W", "Liu X", "Zhou Y",	Theranostics	2023	0
The roles of FLOT1 in human diseases (Review). [PMID:37772385]	Zhan Z, Ye M, Jin X	Molecular medicine reports	2023	0
Perindopril ameliorates experimental Alzheimer's disease progression: role of am [PMID:32488543]	Messiha BAS, Ali MRA, Khattab MM, Abo-Yo	Inflammopharmacology	2020	0
Flotillin membrane domains in cancer. [PMID:32297092]	["Gauthier-Rouvi\u00e8re C", "Bodin S",	Cancer metastasis reviews	2020	0
Prognostic value of flotillins (flotillin-1 and flotillin-2) in human cancers: A [PMID:29499201]	["Deng Y", "Ge P", "Tian T", "Dai C", "W	Clinica chimica acta; internat	2018	0
Glutaminase 1 regulates the release of extracellular vesicles during neuroinflam [PMID:29540215]	["Wu B", "Liu J", "Zhao R", "Li Y", "Pee	Journal of neuroinflammation	2018	0
Cellular uptake of extracellular vesicles is mediated by clathrin-independent en [PMID:28919558]	Costa Verdera H, Gitz-Francois JJ, Schif	Journal of controlled release	2017	0
Elevated LRRK2 autophosphorylation in brain-derived and peripheral exosomes in L [PMID:29166931]	Wang S, Liu Z, Ye T, Mabrouk OS, Maltbie	Acta neuropathologica communic	2017	0
A role for lipid rafts in the protection afforded by docosahexaenoic acid agains [PMID:23907024]	["Aliche-Djoudi F", "Podechard N", "Coll	Food and chemical toxicology :	2013	0
The chemokine, macrophage inflammatory protein-2γ, reduces the expression of glu [PMID:23234294]	["Fang J", "Han D", "Hong J", "Tan Q", "	Journal of neuroinflammation	2012	0
Intoxication of zebrafish and mammalian cells by cholera toxin depends on the fl [PMID:21041954]	["Saslowsky D", "Cho J", "Chinnapen H",	The Journal of clinical invest	2010	0
Flotillin-1 stabilizes caveolin-1 in intestinal epithelial cells. [PMID:19121286]	["Vassilieva E", "Ivanov A", "Nusrat A"]	Biochemical and biophysical re	2009	0

FLOT1

Understanding Entity Pages

Summary

Wiki Pages (17)

FLOT1 Gene

Flotillin-1 Protein

Section 188: Advanced Lipidomics and Membrane Therapy in CBS/PSP

Lipid Raft Dysfunction in Neurodegeneration

ANG — Angiogenin

ANG Protein

Flotillin-2 Protein

Section 134: Advanced Lipidomics and Membrane Therapy in CBS/PSP

epha2

FLOT1 Protein (Flotillin-1)

Section 194: Advanced Membrane Trafficking and Vesicle Dynamics in CBS/PSP

Lysosomal Storage and Lipid Trafficking Therapy in CBS/PSP

Lipid Raft Modulation for Parkinson's Disease (MLSM Hypothesis)

Flotillin-1

Apolipoprotein and Lipid Transport Therapy Landscape

Proteins