gene

GLIOBLASTOMA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GLIOBLASTOMA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2940Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

GLIOBLASTOMA is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, associated with. Associated with ALS, ALZHEIMER'S DISEASE, Aging. Connected to 605 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	GLIOBLASTOMA
Associated Diseases	ALS, Aging, Alzheimer, Breast Cancer, Cancer
Known Drugs/Compounds	TEMOZOLOMIDE
Interactions	C3AR1, ASTROCYTE, FN1, ANXA2, DGAT1, CANCER
KG Connections	1361 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Pathway Diagram

graph TD
    GLIOBLASTOMA["GLIOBLASTOMA"] -->|"associated"| MITOCHONDRIA["MITOCHONDRIA"]
    GLIOBLASTOMA["GLIOBLASTOMA"] -->|"associated"| Tumor["Tumor"]
    GLIOBLASTOMA["GLIOBLASTOMA"] -->|"associated"| Glioblastoma["Glioblastoma"]
    GLIOBLASTOMA["GLIOBLASTOMA"] -->|"activates"| Cancer["Cancer"]
    GLIOBLASTOMA["GLIOBLASTOMA"] -->|"expressed in"| Parkinson["Parkinson"]
    GLIOBLASTOMA["GLIOBLASTOMA"] -->|"expressed in"| Glioblastoma_1["Glioblastoma"]
    PI3K_AKT_MTOR_PATHWAY["PI3K_AKT_MTOR_PATHWAY"] -->|"activates"| GLIOBLASTOMA["GLIOBLASTOMA"]
    MTOR["MTOR"] -->|"activates"| GLIOBLASTOMA["GLIOBLASTOMA"]
    AUTOPHAGY["AUTOPHAGY"] -->|"co discussed"| GLIOBLASTOMA["GLIOBLASTOMA"]
    ALZHEIMER["ALZHEIMER"] -->|"co discussed"| GLIOBLASTOMA["GLIOBLASTOMA"]
    style GLIOBLASTOMA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1061)

Target	Relation	Type	Str
Tumor	associated_with	disease	1.00
Glioblastoma	associated_with	disease	1.00
Cancer	activates	disease	1.00
Glioblastoma	activates	disease	1.00
Tumor	activates	disease	1.00
Tumor	therapeutic_target	disease	1.00
Glioblastoma	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	1.00
Cancer	therapeutic_target	disease	1.00
Tumor	inhibits	disease	1.00
Glioblastoma	inhibits	disease	1.00
Glioblastoma	regulates	disease	1.00
Als	activates	disease	1.00
Glioma	associated_with	disease	1.00
Neurodegeneration	activates	disease	1.00
Glioma	activates	disease	1.00
lipid metabolism	activates	process	0.90
Mtor	activates	pathway	0.90
MTOR	activates	gene	0.90
Autophagy	activates	pathway	0.90
Als	associated_with	disease	0.85
Cancer	associated_with	disease	0.85
Als	regulates	disease	0.85
Cancer	inhibits	disease	0.85
Glioma	therapeutic_target	disease	0.85
Glioma	regulates	disease	0.85
Glioblastoma	treats	disease	0.85
Tumor	treats	disease	0.85
Mtor	therapeutic_target	pathway	0.80
Apoptosis	activates	pathway	0.80
Blood-Brain Barrier	therapeutic_target	pathway	0.80
Tumor Microenvironment	therapeutic_target	pathway	0.80
Invasion	activates	pathway	0.80
Invasion	regulates	pathway	0.80
CANCER	therapeutic_target	gene	0.80
Wnt	activates	pathway	0.80
Pi3K/Akt	therapeutic_target	pathway	0.80
Glioblastoma	expressed_in	disease	0.75
Cancer	expressed_in	disease	0.75
Aging	therapeutic_target	disease	0.75
Cancer	implicated_in	disease	0.75
Inflammation	activates	disease	0.75
Tumor	interacts_with	disease	0.75
Als	treats	disease	0.75
Glioblastoma	implicated_in	disease	0.75
Glioblastoma	causes	disease	0.75
Lipid Metabolism	associated_with	pathway	0.70
Pi3K/Akt	activates	pathway	0.70
Angiogenesis	activates	pathway	0.70
CANCER	activates	gene	0.70

Incoming (1879)

Source	Relation	Type	Str
GBM	associated_with	gene	1.00
CANCER	activates	gene	1.00
GBM	therapeutic_target	gene	1.00
CANCER	therapeutic_target	gene	1.00
EGFR	activates	gene	1.00
IDH1	associated_with	entity	0.98
AKT	associated_with	gene	0.90
MTOR	associated_with	gene	0.90
SREBP1	associated_with	entity	0.90
DGAT1	associated_with	entity	0.90
SOAT1	associated_with	entity	0.90
CYP46A1	downregulates	gene	0.90
PI3K	therapeutic_target	gene	0.90
GBM	activates	gene	0.90
AUTOPHAGY	activates	gene	0.90
MICROGLIA	associated_with	gene	0.82
EGFR	associated_with	gene	0.82
PARKINSON'S DISEASE	associated_with	disease	0.82
PI3K	associated_with	gene	0.82
SMPD1	biomarker_for	gene	0.80
GENES	activates	gene	0.80
GBM	expressed_in	gene	0.80
APOPTOSIS	activates	gene	0.80
TP53	regulates	gene	0.80
EGFR	inhibits	gene	0.80
NEURODEGENERATION	activates	gene	0.80
AKT	therapeutic_target	gene	0.80
NF-KB	associated_with	protein	0.74
GENES	therapeutic_target	gene	0.70
CANCER	expressed_in	gene	0.70
EGFR	therapeutic_target	gene	0.70
NF-ΚB	therapeutic_target	gene	0.70
GENES	associated_with	gene	0.70
GENES	regulates	gene	0.70
PHAGOCYTOSIS	therapeutic_target	gene	0.70
CANCER	inhibits	gene	0.70
FN1	activates	gene	0.70
GBM	regulates	gene	0.70
GBM	implicated_in	gene	0.70
CANCER	implicated_in	gene	0.70
GAIN	activates	gene	0.70
APOPTOSIS	inhibits	gene	0.70
DNA	treats	gene	0.70
DNA	therapeutic_target	gene	0.70
OVERVIEW	therapeutic_target	gene	0.70
STAT3	therapeutic_target	gene	0.70
GBM	treats	gene	0.70
APOPTOSIS	associated_with	gene	0.66
EPILEPSY	regulates	disease	0.65
CHOLINERGIC	causes	cell_type	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What molecular mechanisms drive neuron-to-glioma synapse formation in high-neura

neuro-oncology | 2026-04-13 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

GLIOBLASTOMA

Understanding Entity Pages

Summary

Wiki Pages (20)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

CREB Signaling in Neurodegeneration

Exosome and Extracellular Vesicle Brain Delivery

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Exosome-Based Drug Delivery for CBS/PSP

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TrkB Protein

slc22a1

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NanoCarrier Co., Ltd.

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H3F3B Gene — H3.3 Histone B

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SIGLEC9 — Sialic Acid Binding Ig-Like Lectin 9

NNMT Gene