gene

GABRP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GABRP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

13Connections

0Hypotheses

0Analyses

11Outgoing

2Incoming

0Experiments

0Debates

Summary

GABRP is a gene implicated in neurodegeneration research. Key relationships include: activates, interacts with, implicated in. Associated with Alzheimer, Neuroblastoma, Senescence. Connected to 10 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	GABRP
Full Name	GABA-A Receptor Pi Subunit
Protein Type	Receptor
Function	The GABA-A Receptor Pi Subunit (GABRP) encodes the π (pi) subunit of the GABA-A receptor, a ligand-gated chloride channel that mediates inhibitory neurotransmission in the central nervous system 1.
Primary Expression	reproductive tissues and brain, where it assembles with other subunits to form receptor isoforms with distinct pharmacological and physiological prope
UniProt ID	GABRP
Ensembl ID	ENSG00000068878
GeneCards	GABRP
Human Protein Atlas	GABRP
Brain	cerebral cortex, hippocampus, amygdala
Uterus	endometrial epithelium (highest expression)
Placenta	trophoblast cells
Breast	mammary gland epithelium
Lung	alveolar epithelium
Neurosteroids	enhanced potency at GABRP-containing receptors
Associated Diseases	neurodegeneration
Interactions	ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, DNA, GENES, OPTN
KG Connections	13 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GABRP — GABA-A Receptor Pi Subunit

gene · 509 words

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Pathway Diagram

flowchart TD
    N0["GABRP"]
    N1["Neuroblastoma"]
    N0 -->|"activates"| N1
    N2["Senescence"]
    N0 -->|"interacts with"| N2
    N3["Alzheimer"]
    N0 -->|"activates"| N3
    N4["ALZHEIMER"]
    N0 -->|"activates"| N4
    N5["AMYLOID"]
    N0 -->|"activates"| N5
    N6["GENES"]
    N0 -->|"activates"| N6
    N7["ALZHEIMER'S DISEASE"]
    N0 -->|"activates"| N7
    N8["DNA"]
    N0 -->|"interacts with"| N8
    N9["OPTN"]
    N0 -->|"interacts with"| N9
    N10["neurodegeneration"]
    N0 -->|"implicated in"| N10

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    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 disease
    class N2 disease
    class N3 disease
    class N4 gene
    class N5 gene
    class N6 gene
    class N7 gene
    class N8 gene
    class N9 gene

Outgoing (11)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:GABRP	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Neuroblastoma	activates	disease	0.65
Senescence	interacts_with	disease	0.65
Alzheimer	activates	disease	0.65
ALZHEIMER	activates	gene	0.60
DNA	interacts_with	gene	0.60
AMYLOID	activates	gene	0.60
GENES	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
OPTN	interacts_with	gene	0.60

Incoming (2)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:GABRP	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GABRP in their description or question text

No additional research found