Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GM-CSF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | GM |
| Chromosome | 22q12.1 |
| Function | Granulocyte-macrophage colony-stimulating factor receptor common beta chain (CSF2RB) is the shared signaling component of the GM-CSF receptor family. |
| GeneCards | GM |
| Human Protein Atlas | GM |
| Interactions | CCL2 |
| KG Connections | 11 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["GM-CSF"]
N1["Lactosylceramide"]
N1 -->|"regulates"| N0
N2["LacCer"]
N2 -->|"upregulates"| N0
N3["Monocyte Activation"]
N0 -->|"mediates"| N3
N1 -->|"upregulates"| N0
N4["Astrocytes"]
N0 -->|"activates"| N4
N5["Astrocyte"]
N0 -->|"activates"| N5
N6["Macrophage"]
N0 -->|"activates"| N6
N7["MONOCYTES"]
N0 -->|"activates"| N7
N8["microglia"]
N8 -->|"activates"| N0
N9["CCL2"]
N9 -->|"activates"| N0
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N9 protein| Target | Relation | Type | Str |
|---|---|---|---|
| Monocyte Activation | mediates | process | 0.85 |
| Astrocytes | activates | cell_type | 0.50 |
| Astrocyte | activates | cell_type | 0.50 |
| Macrophage | activates | cell_type | 0.50 |
| MONOCYTES | activates | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Lactosylceramide | regulates | compound | 0.90 |
| LacCer | upregulates | compound | 0.90 |
| Lactosylceramide | upregulates | compound | 0.85 |
| LACCER | regulates | compound | 0.80 |
| microglia | activates | cell_type | 0.50 |
| CCL2 | activates | protein | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||